Związek między stężeniem adiponektyny w surowicy i zwapnieniowym zwężeniem zastawki aortalnej

Background: Adiponectin, an adipose tissue derived cytokine, is known to have antiatherogenic and anti-inflammatory effectson endothelial cells and macrophages. Calcific aortic valve disease has a similar physiopathology to atherosclerosis.Aim: To investigate the relationship between adiponectin and calcific aortic valve disease.Methods: The study group consisted of 58 patients with calcific aortic stenosis and 24 healthy controls. Aortic stenosis patientswere divided into three groups according to their valvular areas: mild (n = 11), moderate (n = 25), and severe (n = 22).Serum adiponectin levels and other biochemical parameters were measured.Results: The aortic stenosis and control group were similar in terms of age, gender and cardiovascular risk factors. Adiponectinmedian values did not differ significantly between two groups (2.19 μg/mL [1.43–3.18], 1.79 μg/mL [1.34–3.42] aorticstenosis and control group, respectively; p = 0.7). Aortic stenosis patients were divided into three groups according to theirvalvular area as mild, moderate and severe. There were no differences when we compared adiponectin levels among thosegroups (mild: 2.10 μg/mL [1.47–3.31], moderate: 2.13 μg/mL [1.44–2.91], severe: 2.65 μg/mL [1.28–3.43]; p = 0.67). Age(r = 0.26, p = 0.045) and aspartate aminotransferase (r = 0.28, p = 0.04) had positive correlations with adiponectin; whilewhite blood cell count (r = –0.32, p = 0.015), fasting blood glucose (r = –0.29, p = 0.03), haemoglobin (r = –0.27, p = 0.04)and triglyceride levels (r = –0.41, p = 0.002) had negative correlations.Conclusions: In our study, we did not find a relationship between adiponectin levels and calcific aortic valve disease.Wstęp: Adiponektyna, cytokina produkowana przez tkankę tłuszczową, ma działanie przeciwmiażdżycowe i przeciwzapalnew stosunku do komórek śródbłonka i makrofagów. Zwapnienie zastawki aorty ma podobny patomechanizm jak miażdżyca.Cel: Celem niniejszej pracy było zbadanie zależności między stężeniem adiponektyny a stopniem zwapnieniowego zwężeniaaorty.Metody: Do badania włączono 58 chorych ze zwapnieniowym zwężeniem aorty i 24 zdrowe osoby stanowiące grupę kontrolną.Chorych ze stenozą aortalną podzielono na 3 grupy w zależności od stopnia zwężenia: osoby z łagodnym (n = 11),umiarkowanym (25) i ciężkim (n = 22) zwężeniem zastawki aortalnej. U wszystkich uczestników badania zmierzono stężenieadiponektyny w surowicy oraz inne parametry biochemiczne.Wyniki: Rozkład wieku, płci i czynników ryzyka sercowo-naczyniowego był podobny w grupie ze stenozą aortalną i w grupiekontrolnej. Porównanie mediany stężenia adiponektyny również nie wykazało istotnej różnicy między grupami [odpowiednio2,19 μg/ml (1,43–3,18); 1,79 μg/ml (1,34–3,42); p = 0,7]. Chorych ze stenozą aortalną podzielono na trzy grupy — z lekkim,umiarkowanym lub ciężkim zwężeniem — w zależności od pola powierzchni ujścia zastawki. Nie stwierdzono różnic, porównującstężenia adiponektyny w tych trzech grupach [łagodne zwężenie: 2,10 μg/ml (1,47–3,31), umiarkowane: 2,13 μg/ml(1,44–2,91), ciężkie: 2,65 μg/ml (1,28–3,43); p = 0,67]. Wiek (r = 0,26; p = 0,045) i stężenie aminotransferazy asparaginianowej(r = 0,28; p = 0,04) korelowały dodatnio ze stężeniem adiponektyny, natomiast w przypadku liczby krwinekbiałych (r = –0,32; p = 0,015), glikemii na czczo (r = –0,29; p = 0,03) oraz stężenia hemoglobiny (r = –0,27; p = 0,04)i triglicerydów (r = –0,41; p = 0,002) wykazano korelację ujemną.Wnioski: W niniejszym badaniu nie wykazano związku stężenia adiponektyny z zwapnieniowym zwężeniem aorty ani zestopniem zwężenia

Re: Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction

We have read with great interest the recently published report of Yazici et al. [1], which investigates the relationship between mean platelet volume (MPV) and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction. The authors demonstrated that increased MPV on admission can be associated with the degree of left ventricle systolic depression in these patients. It has been reported that MPV, a measure of platelet size, reflects platelet function and activity..

Metabolic syndrome increases the risk of significant coronary artery involvement in patients with peripheral artery disease

Background Peripheral artery disease is a common condition, mainly associated with clinical cardiovascular risk factors. Patients with peripheral artery disease suffer from coronary artery disease-related complications. On the other hand, metabolic syndrome, as a constellation of specific risk factors, represents a risk factor for cardiovascular mortality. Metabolic syndrome might increase the risk of significant coronary artery disease in patients with peripheral artery disease. We aimed to examine the association of metabolic syndrome with the angiographically shown coronary artery involvement in patients with peripheral artery disease

Association of lipid profile with echocardiographic Wilkins score in patients with moderate to severe mitral stenosis: Possible impact on prognosis

Background: Association of valvular heart disease and lipid profile might be important as in the case of aortic stenosis. However, it has not been so far considered in detail the probable association of other valvular diseases, particularly of mitral stenosis (MS) with lipid profile. In our study, we aimed to search possible association of echocardiographic mitral valve score, evaluated according to Wilkins score, with lipid parameters in a group of patients with mitral stenosis, who were referred for possible percutaneous balloon valvuloplasty

Relationship between TIMI frame count and admission glucose values in acute ST elevation myocardial infarction patients who underwent successful primary percutaneous intervention

Objective: Admission hyperglycemia is associated with poor prognosis in patients with acute myocardial infarction. Final Thrombolysis in Myocardial Infarction (TIMI) frame counts of culprit coronary arteries may show significant variability despite successful coronary reperfusion after primary percutaneous coronary intervention (PCI). In this prospective observational study, relationship between final TIMI frame counts of the culprit coronary artery and admission glucose values was investigated in patients who underwent successful primary PCI due to acute ST-elevation myocardial infarction (STEMI)