216 research outputs found
Calculation of a Multi-storey Monolithic Concrete Building on the Earthquake in Nonlinear Dynamic Formulation
AbstractThe article deals with a multi-storey monolithic concrete building calculation on the earthquake. The problem is solved in the time domain by a direct dynamic method. Direct integration of motion equations is carried out on an explicit scheme. This technique allows us to solve the problem in a nonlinear dynamic formulation considering geometric and physical nonlinearities. The paper presents and analyzes the main results of the calculation
The GALFA-HI Compact Cloud Catalog
We present a catalog of 1964 isolated, compact neutral hydrogen clouds from
the Galactic Arecibo L-Band Feed Array Survey Data Release One (GALFA-HI DR1).
The clouds were identified by a custom machine-vision algorithm utilizing
Difference of Gaussian kernels to search for clouds smaller than 20'. The
clouds have velocities typically between |VLSR| = 20-400 km/s, linewidths of
2.5-35 km/s, and column densities ranging from 1 - 35 x 10^18 cm^-2. The
distances to the clouds in this catalog may cover several orders of magnitude,
so the masses may range from less than a Solar mass for clouds within the
Galactic disc, to greater than 10^4 Solar Masses for HVCs at the tip of the
Magellanic Stream. To search for trends, we separate the catalog into five
populations based on position, velocity, and linewidth: high velocity clouds
(HVCs); galaxy candidates; cold low velocity clouds (LVCs); warm, low
positive-velocity clouds in the third Galactic Quadrant; and the remaining warm
LVCs. The observed HVCs are found to be associated with previously-identified
HVC complexes. We do not observe a large population of isolated clouds at high
velocities as some models predict. We see evidence for distinct histories at
low velocities in detecting populations of clouds corotating with the Galactic
disc and a set of clouds that is not corotating.Comment: 34 Pages, 9 Figures, published in ApJ (2012, ApJ, 758, 44), this
version has the corrected fluxes and corresponding flux histogram and masse
Compact HI clouds from the GALFA-HI survey
The Galactic Arecibo L-band Feed Array HI (GALFA-HI) survey is mapping the
entire Arecibo sky at 21-cm, over a velocity range of -700 to +700 km/s (LSR),
at a velocity resolution of 0.18 km/s and a spatial resolution of 3.5 arcmin.
The unprecedented resolution and sensitivity of the GALFA-HI survey have
resulted in the detection of numerous isolated, very compact HI clouds at low
Galactic velocities, which are distinctly separated from the HI disk emission.
In the limited area of ~4600 deg surveyed so far, we have detected 96 of
such compact clouds. The detected clouds are cold with a median T
(the kinetic temperature in the case in which there is no non-thermal
broadening) of 300 K. Moreover, these clouds are quite compact and faint, with
median values of 5 arcmin in angular size, 0.75 K in peak brightness
temperature, and cm in HI column density. Most of the
clouds deviate from Galactic rotation at the 20-30 km/s level, and a
significant fraction show evidence for a multiphase medium and velocity
gradients. No counterparts for these clouds were found in other wavebands. From
the modeling of spatial and velocity distributions of the whole compact cloud
population, we find that the bulk of the compact clouds are related to the
Galactic disk, and their distances are likely to be in the range of 0.1 to a
few kpc. We discuss various possible scenarios for the formation and
maintenance of this cloud population and its significance for Galactic ISM
studies.Comment: Accepted for publication in the Astrophysical Journa
Versatile Coordination of Cyclopentadienyl-Arene Ligands and Its Role in Titanium-Catalyzed Ethylene Trimerization
Cationic titanium(IV) complexes with ansa-(η5-cyclopentadienyl,η6-arene) ligands were synthesized and characterized by X-ray crystallography. The strength of the metal-arene interaction in these systems was studied by variable-temperature NMR spectroscopy. Complexes with a C1 bridge between the cyclopentadienyl and arene moieties feature hemilabile coordination behavior of the ligand and consequently are active ethylene trimerization catalysts. Reaction of the titanium(IV) dimethyl cations with CO results in conversion to the analogous cationic titanium(II) dicarbonyl species. Metal-to-ligand backdonation in these formally low-valent complexes gives rise to a strongly bonded, partially reduced arene moiety. In contrast to the η6-arene coordination mode observed for titanium, the more electron-rich vanadium(V) cations [cyclopentadienyl-arene]V(NiPr2)(NC6H4-4-Me)+ feature η1-arene binding, as determined by a crystallographic study. The three different metal-arene coordination modes that we experimentally observed model intermediates in the cycle for titanium-catalyzed ethylene trimerization. The nature of the metal-arene interaction in these systems was studied by DFT calculations.
A Threshold Model for T-Cell Activation in the Era of Checkpoint Blockade Immunotherapy
Continued discoveries of negative regulators of inflammatory signaling provide detailed molecular insights into peripheral tolerance and anti-tumor immunity. Accumulating evidence indicates that peripheral tolerance is maintained at multiple levels of immune responses by negative regulators of proinflammatory signaling, soluble anti-inflammatory factors, inhibitory surface receptors & ligands, and regulatory cell subsets. This review provides a global overview of these regulatory machineries that work in concert to maintain peripheral tolerance at cellular and host levels, focusing on the direct and indirect regulation of T cells. The recent success of checkpoint blockade immunotherapy (CBI) has initiated a dramatic shift in the paradigm of cancer treatment. Unprecedented responses to CBI have highlighted the central role of T cells in both anti-tumor immunity and peripheral tolerance and underscored the importance of T cell exhaustion in cancer. We discuss the therapeutic implications of modulating the negative regulators of T cell function for tumor immunotherapy with an emphasis on inhibitory surface receptors & ligands—central players in T cell exhaustion and targets of checkpoint blockade immunotherapies. We then introduce a Threshold Model for Immune Activation—the concept that these regulatory mechanisms contribute to defining a set threshold of immunogenic (proinflammatory) signaling required to elicit an anti-tumor or autoimmune response. We demonstrate the value of the Threshold Model in understanding clinical responses and immune related adverse events in the context of peripheral tolerance, tumor immunity, and the era of Checkpoint Blockade Immunotherapy
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