Design and Synthesis of Some Novel Michael addition Derivatives of 2,4- Disubstituted Oxazol-5(4H)- One as Possible Anti-Diabetic, Anti-Oxidant and Anti-Fungal Agents.

Diabetes mellitus (DM) is a major degenerative disease in the world today. Several epidemiological and clinical studies indicate a direct relationship between hyperglycemia and long-term complications such as retinopathy, nephropathy, neuropathy and various fungal infections etc. This study was undertaken to evaluate the activity of some Novel Michael Addition derivatives of 2,4-disubstituted Oxazol-5(4H)-one derivatives against Diabetes and its complications by using in vitro enzyme inhibition technique. These derivatives showed considerable biological efficacy when compared to pioglitazone, a potent and well known anti diabetic agent as a reference drug. All the compounds were effective, amongst them di methyl amino benzaldehyde (A6 and B7) and acetaldehyde derivatives (A1 and B1) shown more prominent activity

A VLSI Approach for Cache Compression in Microprocessor

Speed is one of the important issues that generally customers consider for selecting any electronic component in the market. Speed of a microprocessor based system mainly depends on the speed of the microprocessor which in turn depends on the memory access time. Accessing on chip memory takes more time than accessing off-chip memory. Because of these, designers of memory system may find cache compression as an advantageous method to increase speed of a microprocessor based system, as it increases cache capacity and off-chip bandwidth. The However, most past work, and all work on cache compression, has made unsubstantiated assumptions about the performance, power consumption, and area overheads of the proposed compression algorithms and hardware. It is not possible to determine whether compression at levels of the memory hierarchy closest to the processor is beneficial without understanding its costs. Proposed hardware compression algorithms fall into the dictionary-based category, which depend on building a dictionary and using its entries to encode repeated data values. Proposed algorithm has number of novel features like including combining pairs of compressed lines into one cache line and allowing parallel compression of multiple words while using a single dictionary and without degradation in compression ratio

Marine climate and fisheries scenario of Tamil Nadu Climcard-1

Marine climate and fisheries scenario of Tamil Nadu Climcard-

Antihyperlipidemic activity of Chloroxylon swietenia in triton WR1339 induced hyperlipidemia

Background: Medicinal herbs are beneficial and effective either in the management and prevention of several metabolic disorders, associated with hyperlipidemia, hypertension and insulin resistance which increases the cardio-metabolic risk and demands for the life time therapy. Current allopathic medicines are expensive and reported with several adverse effects and hence, finding of a suitable herbal medicine for hyperlipidemic disorders is very important.Methods: Thirty albino rats weighing 200-230g were randomly divided into 5 groups were rendered hyperlipidemia with a single dose of triton WR 1339. Normal control, positive control, standard, aqueous and ethanolic extract groups were treated with tween-80, tween-80, atorvastatin, aqueous and ethanolic extracts of Chloroxylon swietenia respectively for seven days. At the end of the study, blood was collected for estimation of the lipid profile.Results: Both the aqueous and ethanolic extract groups significantly reduced the TG and VLDL levels.Conclusions: The extracts exhibited remarkable activity on one or either parameter of the lipid profile. It could be due to the presence of alkaloids, steroids, flavonoids, coumarins and phenols in the extracts

Translating evidence into policy for cardiovascular disease control in India

Cardiovascular diseases (CVD) are leading causes of premature mortality in India. Evidence from developed countries shows that mortality from these can be substantially prevented using population-wide and individual-based strategies. Policy initiatives for control of CVD in India have been suggested but evidence of efficacy has emerged only recently. These initiatives can have immediate impact in reducing morbidity and mortality. Of the prevention strategies, primordial involve improvement in socioeconomic status and literacy, adequate healthcare financing and public health insurance, effective national CVD control programme, smoking control policies, legislative control of saturated fats, trans fats, salt and alcohol, and development of facilities for increasing physical activity through better urban planning and school-based and worksite interventions. Primary prevention entails change in medical educational curriculum and improved healthcare delivery for control of CVD risk factors-smoking, hypertension, dyslipidemia and diabetes. Secondary prevention involves creation of facilities and human resources for optimum acute CVD care and secondary prevention. There is need to integrate various policy makers, develop effective policies and modify healthcare systems for effective delivery of CVD preventive care

Non-Communicable Disease Risk Factors among Employees and Their Families of a Saudi University: An Epidemiological Study

Objectives:To assess the prevalence of non-communicable disease (NCD) risk factors among Saudi university employees and their families; to estimate the cardiovascular risk (CVR) amongst the study population in the following 10years. Methods:The NCD risk factors prevalence was estimated using a cross-sectional approach for a sample of employees and their families aged ≥ 18 years old, in a Saudi university (Riyadh in Kingdom of Saudi Arabia; KSA). WHO STEPwise standardized tools were used to estimate NCD risk factors and the Framingham Coronary Heart Risk Score calculator was used to calculate the CVR. Results:Five thousand and two hundred subjects were invited, of whom 4,500 participated in the study, providing a response rate of 87%. The mean age of participants was 39.3±13.4 years. The majority of participants reported low fruit/vegetables consumption (88%), and physically inactive (77%). More than two thirds of the cohort was found to be either overweight or obese (72%), where 36% were obese, and 59% had abdominal obesity. Of the total cohort, 22–37% were found to suffer from dyslipidaemia, 22% either diabetes or hypertension, with rather low reported current tobacco use (12%). One quarter of participants was estimated to have >10% risk to develop cardiovascular disease within the following 10-years. Conclusion:The prevalence of NCD risk factors was found to be substantially high among the university employees and their families in this study