Self-Asymmetric Invertible Network for Compression-Aware Image Rescaling

High-resolution (HR) images are usually downscaled to low-resolution (LR) ones for better display and afterward upscaled back to the original size to recover details. Recent work in image rescaling formulates downscaling and upscaling as a unified task and learns a bijective mapping between HR and LR via invertible networks. However, in real-world applications (e.g., social media), most images are compressed for transmission. Lossy compression will lead to irreversible information loss on LR images, hence damaging the inverse upscaling procedure and degrading the reconstruction accuracy. In this paper, we propose the Self-Asymmetric Invertible Network (SAIN) for compression-aware image rescaling. To tackle the distribution shift, we first develop an end-to-end asymmetric framework with two separate bijective mappings for high-quality and compressed LR images, respectively. Then, based on empirical analysis of this framework, we model the distribution of the lost information (including downscaling and compression) using isotropic Gaussian mixtures and propose the Enhanced Invertible Block to derive high-quality/compressed LR images in one forward pass. Besides, we design a set of losses to regularize the learned LR images and enhance the invertibility. Extensive experiments demonstrate the consistent improvements of SAIN across various image rescaling datasets in terms of both quantitative and qualitative evaluation under standard image compression formats (i.e., JPEG and WebP).Comment: Accepted by AAAI 2023. Code is available at https://github.com/yang-jin-hai/SAI

Towards Blind Watermarking: Combining Invertible and Non-invertible Mechanisms

Blind watermarking provides powerful evidence for copyright protection, image authentication, and tampering identification. However, it remains a challenge to design a watermarking model with high imperceptibility and robustness against strong noise attacks. To resolve this issue, we present a framework Combining the Invertible and Non-invertible (CIN) mechanisms. The CIN is composed of the invertible part to achieve high imperceptibility and the non-invertible part to strengthen the robustness against strong noise attacks. For the invertible part, we develop a diffusion and extraction module (DEM) and a fusion and split module (FSM) to embed and extract watermarks symmetrically in an invertible way. For the non-invertible part, we introduce a non-invertible attention-based module (NIAM) and the noise-specific selection module (NSM) to solve the asymmetric extraction under a strong noise attack. Extensive experiments demonstrate that our framework outperforms the current state-of-the-art methods of imperceptibility and robustness significantly. Our framework can achieve an average of 99.99% accuracy and 67.66 dB PSNR under noise-free conditions, while 96.64% and 39.28 dB combined strong noise attacks. The code will be available in https://github.com/rmpku/CIN.Comment: 9 pages, 9 figures, 5 table

Integrated analysis of single-cell and Bulk RNA sequencing reveals a malignancy-related signature in lung adenocarcinoma

BackgroundLung adenocarcinoma (LUAD), the most common histotype of lung cancer, may have variable prognosis due to molecular variations. The research strived to establish a prognostic model based on malignancy-related risk score (MRRS) in LUAD.MethodsWe applied the single-cell RNA sequencing (scRNA-seq) data from Tumor Immune Single Cell Hub database to recognize malignancy-related geneset. Meanwhile, we extracted RNA-seq data from The Cancer Genome Atlas database. The GSE68465 and GSE72094 datasets from the Gene Expression Omnibus database were downloaded to validate the prognostic signature. Random survival forest analysis screened MRRS with prognostic significance. Multivariate Cox analysis was leveraged to establish the MRRS. Furthermore, the biological functions, gene mutations, and immune landscape were investigated to uncover the underlying mechanisms of the malignancy-related signature. In addition, we used qRT-PCR to explore the expression profile of MRRS-constructed genes in LUAD cells.ResultsThe scRNA-seq analysis revealed the markers genes of malignant celltype. The MRRS composed of 7 malignancy-related genes was constructed for each patient, which was shown to be an independent prognostic factor. The results of the GSE68465 and GSE72094 datasets validated MRRS’s prognostic value. Further analysis demonstrated that MRRS was involved in oncogenic pathways, genetic mutations, and immune functions. Moreover, the results of qRT-PCR were consistent with bioinformatics analysis.ConclusionOur research recognized a novel malignancy-related signature for predicting the prognosis of LUAD patients and highlighted a promising prognostic and treatment marker for LUAD patients

Design of aromatic thermosetting polyester composites for thermally stable devices

Aromatic thermosetting copolyester (ATSP) has been under development since 1995 in Professor James Economy’s research group at the University of Illinois, Urbana-Champaign. It can be seen as a major development in high performance polymers as it affords a highly processable series of routes towards diverse form factors that may need to utilize a highly thermally resistant (and therefore all-aromatic) thermosetting polymer. Prior and current study has demonstrated its outstanding thermal stability and resistance to flame, capability of ablation and high wear resistance. It shows strong bonding with fibers and thus ATSP can be used as resin matrix in polymer/fiber composites. ATSP is soluble in a number of polar aprotic solvents and can be in this regard used as an effective tribological and corrosion coating for metal components. The two-step synthesis of the ATSP is an effective and smooth synthesis that affords an immense range of tailorability both in terms of cross-link density and constituent monomers. In this thesis, firstly, new aromatic monomers, such as resorcinol diacetate and 3, 5-diacctoxybenzoic acid, are employed in the synthesis of ATSP oligomers. These have the effect of reducing condensation reaction temperature and the viscosity of the oligomer and its solutions. In the thesis, firstly, several new aromatic monomers are added to the ATSP synthesis. The condensation reaction temperature reduces and the viscosity of the oligomer solution significantly drops. Secondly, H1-NMR is introduced into the characterization. Average molecular weight of each batch of oligomers can be calculated by a simple relationship. Origins of liquid crystalline feature are discussed and more oligomers are synthesized. After reviewing the work on ATSP/carbon fiber composites, ATSP/glass fiber composite was fabricated. The thickness of the composite laminate can be easily controlled by bonding cured thin laminate together in a solid-state manner. The interlaminar shear strength of ATSP/glass fiber is measured by single fiber fragmentation test. Fiber induced local orientation of ATSP is observed. ITR process is proved to be effective in repairing the cracks and scratches of composites. In addition, the first electrical property test is achieved on ATSP/glass fiber composite. The insertion loss is less than standard circuit board FR-4

The Influence of Fracture Strain Energy on the Burst Tendency of Coal Seams and Field Application

Coal is typically considered a special engineering rock mass because of its low strength, high internal fracture development, good permeability, and random distribution of microparticles and fractures. The results of cyclic loading and unloading tests indicate that the strain energy during the coal deformation process can be divided into three parts: plastic strain energy; fracture strain energy; and base-material strain energy. The energy composition ratio differs depending on coal strength. Lower proportions of fracture strain energy are associated with higher elastic energy indexes, and there is a negative correlation between fracture strain energy and other coal burst tendency indexes. The results were applied on the 4206 isolated island working face of coal mine A in Yan’an, Shanxi, China, yielding good benefits. The findings presented here provide a theoretical basis for understanding the principle of coal seam bursting and guidance for reducing burst risks

Long-Term Prognostic Value of Myocardial Viability by Myocardial Contrast Echocardiography in Patients after Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

Background and Objectives: According to recent guidelines, myocardial contrast echocardiography (MCE) is recommended for detecting residual myocardial viability (MV). However, the long-term prognostic value of MV as assessed by MCE in identifying major adverse cardiac events (MACE) after acute myocardial infarction (AMI) remains undefined. Materials and Methods: We searched multiple databases, including PubMed, EMBASE, and Web of Science for studies on the prognostic value of MCE for clinical outcomes in AMI patients. The primary endpoints were MACEs during follow-up. Six studies that evaluated a total of 536 patients with a mean follow-up of 36.8 months were reviewed. Results: The pooled sensitivity and specificity of MCE for predicting MACEs were 0.80 and 0.78, respectively, and the summary operating receiver characteristics achieved an area under the curve of 0.84. The pooled relative risks demonstrated that the MV evaluated by MCE after AMI was correlated with a high risk for total cardiac events (pooled relative risk: 2.07; 95% confidence interval: 1.28–3.37) and cardiac death (pooled relative risk: 2.48; 95% confidence interval: 1.03–5.96). MV evaluated by MCE was a highly independent predictor of total cardiac events (pooled hazard ratio: 2.09, 95% confidence interval: 1.14–3.81) in patients after AMI. Conclusions: Residual MV evaluated by MCE may be an effective long-term prognostic tool for predicting MACE in patients after AMI that can provide moderate predictive accuracy. The assessment of MV by MCE may become an alternative technique with the potential to rapidly provide important information for improving long-term risk stratification in patients after AMI, at the bedside in clinical practice, especially for patients who cannot tolerate prolonged examinations. The PROSPERO registration number is CRD42020167565

Organophosphorus flame retardants and their metabolites in paired human blood and urine

Organophosphorus flame retardants (OPFRs) have been shown to be carcinogenic, neurotoxic, and endocrine disruptive, so it is important to understand the levels of OPFRs in human body as well as the modes of external exposure. In this study, we investigated the levels of 13 OPFRs and 7 phosphodiester metabolites in paired human blood and urine, as well as the influencing factors (region, age and gender), and studied the relationship between OPFRs and oxidative stress by urinary metabolites. We found that the concentrations of triphenyl phosphate (TPhP) and tris-(2-ethylhexyl) phosphate (TEHP) in the blood of urban populations were higher than those of rural populations, and that younger populations suffered higher TPhP and 2-ethylhexyl diphenyl phosphate (EHDPP) exposures than older populations. In addition, we found that tris-(2-chloroethyl) phosphate (TCEP), tributyl phosphate (TnBP), TPhP and EHDPP exposure induced oxidative stress. The results of the internal load principal component analysis indicated that dust ingestion, skin exposure, respiration and dietary intake may be the most important sources of TCEP, tris(2-butoxyethyl) phosphate (TBOEP), tri(2-chloroisopropyl) phosphate (TCIPP) and TEHP, respectively, and dust ingestion and skin exposure may be the main sources of TPhP for humans

Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus

Myostatin (MSTN) is a negative regulator of skeletal muscle growth and development. The mechanisms of fish MSTN involved in muscle growth are not fully understood. In the present study, knockdown and overexpression of mstn-1 was performed in cultured Japanese flounder muscle cells to investigate the molecular function and the underlying mechanism of fish MSTN-1. Results showed that mstn-1 knockdown significantly induced cell proliferation and the mRNA expression of myogenic regulatory factors (MRFs), while overexpression of mstn-1 led to a significant decrease of cell proliferation and a suppression of the MRFs mRNA expression. The overexpression of mstn-1 also significantly increased the mRNA expression of ubiquitin–proteasomal pathway of proteolysis genes including muscle RING-finger protein 1 (murf-1) by 204.1% (p = 0.024) and muscle atrophy F-box protein (mafbx) by 165.7% (p = 0.011). However, mystn-1 overexpression inhibited the activation of mTOR signal pathway and the AKT/FoxO1 pathway through decreasing phosphorylation of AKT at Ser 473 by 56.0% (p = 0.001). Meanwhile, mystn-1 overexpression increased the dephosphorylation and nuclear localization of FoxO1 by 394.9% (p = 0.005). These results demonstrate that mstn-1 in Japanese flounder has the effects of inhibiting cell proliferation and growth, and the mTOR and AKT/FoxO1 pathways participated in these biological effects

Energy Variation Law and Rockburst Characteristics of Coal under Cyclic Loading

Coal mining involves numerous challenges and safety risks owing to the complex engineering properties of coal bodies, which include discontinuities, heterogeneity, and anisotropy. In this paper, the strain energy during the coal deformation process is redivided in combination with cyclic loading and unloading tests to determine the energy evolution law and discuss the rockburst tendency characteristics. The results show that the elastic strain energy, and particularly the base-material strain energy, consistently dominates during the energy adjustment process, which is an important indicator of rockburst tendency. The elastic energy index and rebound deformation index also show that moderate plastic deformation (e.g., crack expansion and local penetration) can reduce the rockburst tendency level and prevent rockburst accidents. On the basis of the obtained results, precracking and pressure relief measures of blasting are adopted on site in advance of the working face, and good safety and economic benefits are achieved. These findings, thus, provide an important engineering reference for mines under similar conditions

Can We Retrieve the Information Which Was Intentionally Forgotten? Electrophysiological Correlates of Strategic Retrieval in Directed Forgetting

Retrieval inhibition hypothesis of directed forgetting effects assumed TBF (to-be-forgotten) items were not retrieved intentionally, while selective rehearsal hypothesis assumed the memory representation of retrieved TBF (to-be-forgotten) items was weaker than TBR (to-be-remembered) items. Previous studies indicated that directed forgetting effects of item-cueing method resulted from selective rehearsal at encoding, but the mechanism of retrieval inhibition that affected directed forgetting of TBF (to-be-forgotten) items was not clear. Strategic retrieval is a control process allowing the selective retrieval of target information, which includes retrieval orientation and strategic recollection. Retrieval orientation via the comparison of tasks refers to the specific form of processing resulted by retrieval efforts. Strategic recollection is the type of strategies to recollect studied items for the retrieval success of targets. Using a “directed forgetting” paradigm combined with a memory exclusion task, our investigation of strategic retrieval in directed forgetting assisted to explore how retrieval inhibition played a role on directed forgetting effects. When TBF items were targeted, retrieval orientation showed more positive ERPs to new items, indicating that TBF items demanded more retrieval efforts. The results of strategic recollection indicated that: (a) when TBR items were retrieval targets, late parietal old/new effects were only evoked by TBR items but not TBF items, indicating the retrieval inhibition of TBF items; (b) when TBF items were retrieval targets, the late parietal old/new effect were evoked by both TBR items and TBF items, indicating that strategic retrieval could overcome retrieval inhibition of TBF items. These findings suggested the modulation of strategic retrieval on retrieval inhibition of directed forgetting, supporting that directed forgetting effects were not only caused by selective rehearsal, but also retrieval inhibition