Study of fluoride corrosion of nickel alloys

Report contains the results of an investigation of the corrosion resistance of nickel and nickel alloys exposed to fluorine, uranium hexafluoride, and volatile fission product fluorides at high temperatures. Survey of the unclassified literature on the subject is included

Increasing the efficiency of pooled estimation with a block covariance structure

Econometrics ; Econometric models

Discrimination of rock classes and alteration products in southwestern Saudi Arabia with computer-enhanced LANDSAT data

Digital LANDSAT MSS data for an area in the southwestern Arabian Shield were computer-enhanced to improve discrimination of rock classes, and recognition of gossans associated with massive sulphide deposits. The test area is underlain by metamorphic rocks that are locally intruded by granites; these are partly overlain by sandstones. The test area further includes the Wadi Wassat and Wadi Qatan massive sulphide deposits, which are commonly capped by gossans of ferric oxides, silica, and carbonates. Color patterns and boundaries on contrast-stretched ratio color composite imagery, and on complementary images constructed using principal component and canonical analyses transformations, correspond exceptionally well to 1:100,000 scale field maps. A qualitative visual comparison of information content showed that the ratio enhancement provided the best overall image for identification of rock type and alteration products

U.S. banks, competition, and the Mexican banking system: how much will NAFTA matter?

Bank competition ; North American Free Trade Agreement ; Mexico

A hybrid parametrical wave prediction model

The development of a numerical wave prediction model incorporating a parametrical wind-sea model and a characteristic swell model is described. The parametrical model is an extension of an earlier two-parameter model to the full five Jonswap spectral parameters. An application is presented in which the model is used to hindcast severe wave conditions in the North Sea as part of an engineering study to define long-term extreme wave statistics for the area. The limitations of the model and the needs for future research are discussed

Synthesis and investigation of the spectral-luminescence characteristics of powder based on zinc oxide

ZnO and ZnAlO composites were synthesized by thermal decomposition of a precursor salt, dried at 200 °C and annealed at 400 and 600 °C, respectively. It was shown that pH and temperature of synthesis has great influence on the spectral-luminescence properties of samples

Anisotropic Inflation and the Origin of Four Large Dimensions

In the context of (4+d)-dimensional general relativity, we propose an inflationary scenario wherein 3 spatial dimensions grow large, while d extra dimensions remain small. Our model requires that a self-interacting d-form acquire a vacuum expectation value along the extra dimensions. This causes 3 spatial dimensions to inflate, whilst keeping the size of the extra dimensions nearly constant. We do not require an additional stabilization mechanism for the radion, as stable solutions exist for flat, and for negatively curved compact extra dimensions. From a four-dimensional perspective, the radion does not couple to the inflaton; and, the small amplitude of the CMB temperature anisotropies arises from an exponential suppression of fluctuations, due to the higher-dimensional origin of the inflaton. The mechanism triggering the end of inflation is responsible, both, for heating the universe, and for avoiding violations of the equivalence principle due to coupling between the radion and matter.Comment: 24 pages, 2 figures; uses RevTeX4. v2: Minor changes and added references. v3: Improved discussion of slow-rol

Hydrazones and Thiosemicarbazones Targeting Protein-Protein-Interactions of SARS-CoV-2 Papain-like Protease

The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and, additionally, dysregulation of the host innate immune system. Using a library of 40 potential metal-chelating compounds we performed an X-ray crystallographic screening against PLpro. As outcome we identified six compounds binding to the target protein. Here we describe the interaction of one hydrazone (H1) and five thiosemicarbazone (T1-T5) compounds with the two distinct natural substrate binding sites of PLpro for ubiquitin and ISG15. H1 binds to a polar groove at the S1 binding site by forming several hydrogen bonds with PLpro. T1-T5 bind into a deep pocket close to the polyubiquitin and ISG15 binding site S2. Their interactions are mainly mediated by multiple hydrogen bonds and further hydrophobic interactions. In particular compound H1 interferes with natural substrate binding by sterical hindrance and induces conformational changes in protein residues involved in substrate binding, while compounds T1-T5 could have a more indirect effect. Fluorescence based enzyme activity assay and complementary thermal stability analysis reveal only weak inhibition properties in the high micromolar range thereby indicating the need for compound optimization. Nevertheless, the unique binding properties involving strong hydrogen bonding and the various options for structural optimization make the compounds ideal lead structures. In combination with the inexpensive and undemanding synthesis, the reported hydrazone and thiosemicarbazones represent an attractive scaffold for further structure-based development of novel PLpro inhibitors by interrupting protein-protein interactions at the S1 and S2 site