Exploring the role of voluntary disease schemes on UK farmer bio-security behaviours: Findings from the Norfolk-Suffolk Bovine Viral Diarrhoea control scheme

The article describes the influence of a disease control scheme (the Norfolk-Suffolk Bovine Viral Diarrhoea Disease (BVD) Eradication scheme) on farmers' bio-security attitudes and behaviours. In 2010, a survey of 100 cattle farmers (53 scheme members vs. 47 out of scheme farmers) was undertaken among cattle farmers residing in Norfolk and Suffolk counties in the UK. A cross-sectional independent measures design was employed. The main analytical tool was content analysis. The following variables at the farmer-level were explored: the specific BVD control measures adopted, livestock disease priorities, motivation for scheme membership, wider knowledge acquisition, biosecurity behaviours employed and training course attendance. The findings suggest that participation in the BVD scheme improved farmers' perception of the scheme benefits and participation in training courses. However, no association was found between the taking part in the BVD scheme and livestock disease priorities or motivation for scheme participation, or knowledge about BVD bio-security measures employed. Equally importantly, scheme membership did appear to influence the importance accorded specific bio-security measures. Yet such ranking did not appear to reflect the actual behaviours undertaken. As such, disease control efforts alone while necessary, are insufficient. Rather, to enhance farmer bio-security behaviours significant effort must be made to address underlying attitudes to the specific disease threat involved

Wavefront shaping of a Bessel light field enhances light sheet microscopy with scattered light

The project was supported by the UK Engineering and Physical Sciences Research Council, RS MacDonald Charitable Trust, SULSA, and the St. Andrews 600th anniversary BRAINS appeal. K. D. is a Royal Society Wolfson Merit Award holder.Light sheet microscopy has seen a resurgence as it facilitates rapid, high contrast, volumetric imaging with minimal sample exposure. Initially developed for imaging scattered light, this application of light sheet microscopy has largely been overlooked but provides an endogenous contrast mechanism which can complement fluorescence imaging and requires very little or no modification to an existing light sheet fluorescence microscope. Fluorescence imaging and scattered light imaging differ in terms of image formation. In the former the detected light is incoherent and weak whereas in the latter the coherence properties of the illumination source, typically a laser, dictate the coherence of detected light, but both are dependent on the quality of the illuminating light sheet. Image formation in both schemes can be understood as the convolution of the light sheet with the specimen distribution. In this paper we explore wavefront shaping for the enhancement of light sheet microscopy with scattered light. We show experimental verification of this result, demonstrating the use of the propagation invariant Bessel beam to extend the field of view of a high resolution scattered light, light sheet microscope and its application to imaging of biological super-cellular structures with sub-cellular resolution. Additionally, complementary scattering and fluorescence imaging is used to characterize the enhancement, and to develop a deeper understanding of the differences of image formation between contrast mechanisms in light sheet microscopy.Publisher PD

Alkali-activated cements for ground improvement

The paper studies alkali-activated (AA) slag cements for soil stabilisation, as alternatives to traditional binders such as Portland cement or lime. A number of alkali activators were considered, containing also a range of salts and a material retrieved from waste (Paper Sludge Ash, PSA). The results are discussed in terms of unconfined compressive strength (UCS) at two different curing times. In general alkali-activated cements based on the use of alkali salts only had a modest performance in terms of strength improvement; a material that showed promise however as slag activator was the PSA. Further analysis is recommended in order to gain a better understanding of the complex mechanisms involved towards engineering uses for soil stabilisation

Effect of Excess Dietary Crude Protein from Corn Gluten Meal or Soybean Meal on Reproductive Function of Beef Cows Consuming Low Quality Forage

Coproducts of the ethanol industry are a concentrated package of crude protein (CP) which can be fed to beef cows in conjunction with low quality forage to make economical diets that meets nutrient requirements. With this pairing, having excess dietary CP is likely; however the effects of these excessive CP diets on beef cow reproduction have not been made clear. In addition, the effects of excess dietary CP from feedstuffs that differ in rumen degradability are not known. In the present study, we studied the effects of diets containing 150% of metabolizable protein (MP) requirements from a moderately high (corn gluten meal) or low (soybean meal) rumen undegradable protein (RUP) fraction on reproductive function around the time of ovulation. We observed that excess dietary RUP enhanced dominant follicle growth and ovulatory parameters, while excess dietary rumen degradable protein (RDP) improved circulating progesterone concentration post ovulation. Based on these data, source of CP when fed to excess may have differential impacts on reproductive function in mature beef cows. However, the mechanisms by which these physiological alterations occur are unknown at this time. Thus, more research is warranted to elucidate how source and amount of CP, when supplemented in low quality forage-based diets, may influence reproductive function in beef cows

How to design and evaluate interventions to improve outcomes for patients with multimorbidity

Multimorbidity is a major challenge for patients and healthcare providers. The limited evidence of the effectiveness of interventions for people with multimorbidity means that there is a need for much more research and trials of potential interventions. Here we present a consensus view from a group of international researchers working to improve care for people with multimorbidity to guide future studies of interventions. We suggest that there is a need for careful consideration of whom to include, how to target interventions that address specific problems and that do not add to treatment burden, and selecting outcomes that matter both to patients and the healthcare system. Innovative design of these interventions will be necessary as many will be introduced in service settings and it will be important to ensure methodological rigour, relevance to service delivery, and generalizability across healthcare systems

Combined Reconstruction and Registration of Digital Breast Tomosynthesis

Digital breast tomosynthesis (DBT) has the potential to en- hance breast cancer detection by reducing the confounding e ect of su- perimposed tissue associated with conventional mammography. In addi- tion the increased volumetric information should enable temporal datasets to be more accurately compared, a task that radiologists routinely apply to conventional mammograms to detect the changes associated with ma- lignancy. In this paper we address the problem of comparing DBT data by combining reconstruction of a pair of temporal volumes with their reg- istration. Using a simple test object, and DBT simulations from in vivo breast compressions imaged using MRI, we demonstrate that this com- bined reconstruction and registration approach produces improvements in both the reconstructed volumes and the estimated transformation pa- rameters when compared to performing the tasks sequentially