Improved Hybrid Algorithm Approach based Load Balancing Technique in Cloud Computing

The routine life of modern citizens is completely dominated by the computer aided services The computer aided services depends on information and communication technologies The success behind this cloud computing are data centers with virtualization technology equipped with fastest internet and the wide acceptance of the users due to its affordable price to the common people Effective services can be provided to the end user only when proper scheduling of tasks are done in peak hours when heterogeneous collection of requests are coming to the data cente

Aspirin Prophylaxis for the Prevention of Thrombosis: Expectations and Limitations

Platelets play a very important role in the pathogenesis of acute vascular events leading to thrombosis of the coronary and cerebral arteries. Blockage of these arteries leading to regional ischemia of heart and brain tissues precipitate heart attacks and stroke. Acetyl salicylic acid (Aspirin) has been the drug of choice for over half a century for the primary and secondary prophylaxis of thrombotic events. In spite of its extensive use as an antiplatelet drug for the prevention of vascular thrombosis, there is considerable concern about the degree of protection it offers, to patients under aspirin therapy. In this paper, we explain the phenomenon of aspirin resistance, discuss the limitations of aspirin therapy, and suggest methods to monitor “at-risk” individuals. Ability to monitor and determine at risk patients will provide opportunities for the clinicians to customize antiplatelet therapies

Biomedical Research and Healthcare: Opportunities, Expectations, and Limitations

The last fifty years have been the “golden era” of biomedical research and innovation. Major discoveries in genetics, genomics and various fields of “Omics”, together with the technology revolution, has created unlimited opportunities for the development, and improvements in the way the healthcare is delivered. Not a single day goes by, without an announcement of a new sensor, new app, or a new and novel technology, that can be integrated with the wealth of knowledge in biomedical research and applications. To the extent, one of the largest insurance provider, John Hancock announced, that they no longer offer policies, that do not include digital tracking. They will sell only “interactive” policies that collect health data through wearable devices, such as smart watch. The breakthroughs in biomedicine, and advances in technologies, have been miraculous. This is especially true in the USA, which is the envy of other nations, when it comes to innovations in research and technology. The fact that all of these innovations are “news makers” creates great expectations from the care receivers. Having said that, patients, clinicians, and healthcare providers feel at times a letdown, or question the slow pace of advance, escalating cost, sometimes dubious clinical values and inappropriate exploitations. Policy makers and economists are debating, about the cost-effectiveness and the return on the investment in biomedical research, as it relates to improvements in health care. Researchers worldwide are debating about the availability of “Precision Medicine” and “Personalized Medicine.” Despite the developments in biomedical research and emerging technologies, which have raised our expectations and created infinite opportunities, there seems to be some limitations in their applications. In this mini review, we will briefly discuss some of the developments in biomedical research and innovation. We will also express our views on the opportunities available and explain limitations

Some scientific problems of the sugar industry

Obviously the problems of the sugar industry are numerous and call for intensified efforts and team work for solution. There are immense possibilities of such efforts resulting in increased yield and quality of sugarcane, decrease in manure, labour and manufacturing costs and in the end the overall costs of sugar production. Crores of rupees have been collected from the industry for research and development, but very little actually used for this purpose. It is in the realisation of the very great importance of intensive research and in the proper utilisation of the funds that the future of the industry rests for its survival

Activated carbon from bagasse

This article does not have an abstract

Acute Vascular Events: Cellular and Molecular Mechanisms

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An estimated 17.9 million individuals died from CVDs in 2019, representing 32% of all global deaths. Of these deaths, 85% were due to heart attack and stroke. Cardiometabolic risks, such as hypertension, excess weight, obesity, type 2 diabetes, and vascular diseases, contribute significantly to the progression of coronary artery disease. Known sequelae of events that lead to these cardiometabolic diseases include oxidative stress, inflammation, development of dysfunction of vascular adipose tissue, altered blood pressure and blood lipids, altered glucose metabolism, hardening of the arteries, endothelial dysfunction, development of atherosclerotic plaques, and activation of platelet and coagulation pathways. The Framingham Heart Study Group has developed a Risk Score that estimates the risk of developing heart disease in a 10-year period. This group of experts has developed mathematical functions for predicting clinical coronary disease events. These prediction capabilities are derived by assigning weights to major CVD risk factors such as sex, age, blood pressure, total cholesterol, low-density lipoprotein, high-density lipoprotein cholesterol, smoking behavior, and diabetes status. Currently, there is a growing interest in the use of artificial intelligence and machine learning applications. AI-based mimetic pattern-based algorithms seem to be better than the conventional Framingham Risk Score, in predicting clinical events related to CVDs. However, there are limitations to these applications as they do not have access to data on the specific factors that trigger acute vascular events, such as heart attack and stroke. This overview briefly discusses some salient cellular and molecular mechanisms involved in precipitating thrombotic conditions. Further improvements in emerging technologies will provide greater opportunities for patient selection and treatment options. Several clinical studies have demonstrated that most CVDs can be prevented by addressing behavioral risk factors such as tobacco use, unhealthy diet and obesity, physical activity, and harmful use of alcohol. Early detection and better management of the modifiable risks seem to be the only way to reduce, reverse, or prevent these diseases

Thermoluminescence and defect centers in synthetic diopside

MgCaSi2O6 polycrystal was synthesized by the devitrification method. The dosimetric characteristics by TL of this prepared polycrystal was investigated. This material exhibits TL peaks at 115, 160, 210, 260 and 280 °C. The dosimetric peak occurs at 260 °C with a well defined glow curve structure. This peak shows a linear dose response. Electron paramagnetic resonance (EPR) studies have been carried out to identify the defect centers responsible for the TL peaks. Two defect centers in the region of g = 2.0 are found. One of the centers (center I) with a g factor equal to 2.0085 is identified as O− -ion and relates with the observed high temperature 250 and 300 °C TL peaks. Additional defect centers with g = 2.0012 (center II) and 1.982 (center III) are due to F+- centers (electron trapped at an oxygen vacancy). Center II and III correlate with the TL peaks at 160 °C and 106 °C, respectively.Campus Arequip

Dating stalagmite from Caverna do Diabo (Devil'S Cave) by TL and EPR techniques

A cylindrical fragment of stalagmite from Caverna do Diabo, State of Sao Paulo, Brazil, has been studied and dated by thermoluminescence and electron paramagnetic resonance techniques. The thermoluminescence glow curves of stalagmite samples and subsequently gamma irradiated, have shown rise of three peaks at 135, 180 and 265 degrees C. From electron paramagnetic resonance spectra of stalagmite was possible to clearly identify three paramagnetic centers in the g = 2.0 region: Centers I, II and III are due to, CO3- and CO33-, respectively. The additive method was applied to calculate the accumulated dose using thermoluminescence peak at 265 degrees C and the electron paramagnetic resonance signal at g = 1.9973 of CO2- radical. The ages of the different slices of stalagmite were determined from the D-ac-values and D-an-value, obtaining an average of 86410 for central slice, 53421 for second slice, 31490 for third slice and 46390 years B.P. for the central region of upper end.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Sao Paulo, Inst Fis, Rua Matao,187 Cidade Univ, BR-05508090 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Mar, Rua Doutor Carvalho de Mendonca 144, BR-11070100 Santos, SP, BrazilIPEN CNEN SP, Inst Pesquisas Energet & Nucl, Av Prof Lineu Prestes,2242 Cidade Univ, BR-05508000 Sao Paulo, SP, BrazilUniv Nacl San Agustin, Fac Ciencias Nat & Formales, Escuela Profes Fis, Av Independencia S-N, Arequipa, PeruUniv Sao Paulo, Escola Politecn, Dept Engn Met & Mat, Av Prof Mello Moraes 2463, BR-05508030 Sao Paulo, SP, BrazilDepartamento de Ciências do Mar, Universidade Federal de São Paulo, Rua Doutor Carvalho de Mendonça, 144, 11070-100 Santos, SP, BrazilFAPESP: 2014/03085-0CAPES: BEX-9612130Web of Scienc