Frequency in the anomalous origin of the left main coronary artery with angiography in a Turkish population.

We estimated the frequency of anatomic variations in origin of the left coronary artery in a Turkish population by analyzing the angiographic data of 10,042 consecutive adult patients undergoing coronary angiography. Among 10,042 adult patients, 5 (0.04%) patients (4 men and 1 woman, age range 40-74, median 58 years old) had anomalous origin of the left main coronary artery. The left main coronary artery arose from the right coronary sinus of Valsalva in 2 (0.019%) patients (both of them had a retro-aortic course), from above the left coronary sinus of Valsalva in 2 (0.019%) patients, and from above the non-coronary (posterior)-left coronary commisure in 1 (0.009%) patient. Anomalous origin of the left main coronary artery is potentially a serious condition, as it can lead to myocardial infarction and sudden cardiac death under physical exertion. Therefore, greater effort for early detection and surgical repair of this anomaly are warranted. The angiographic recognition of anomalous origin of this vessel may prove useful for physicians dealing with diagnosis and treatment of anomalies of the left main coronary artery.</p

Bilateral triple renal arteries

Knowledge of the variations of the renal artery has grown in importance with increa-sing numbers of renal transplants, vascular reconstructions and various surgical and radio logic tech-niques being performed in recent years. We report the presence of bilateral triple renal arteries, dis-covered on routine dissection of a male cadaver. On the right side, one additional renal artery ori-ginated from the abdominal aorta (distributed to superior pole of the kidney) and one other ori-ginated from the right common iliac artery (distributed to lower pole of the kidney). On the left side, both additional renal arteries originated from the abdominal aorta. Our observation has been com-pared with variations described in the literature and their clinical importance has been emphasized

A Magnetic Resonance Imaging Study of the Corpus Callosum Volume in Schizophrenia

Conclusion: Corpus callosum volume was significantly reduced in schizophrenic group. Evidence of reduced interhemispheric communication in schizophrenia may be important in explaining the associations between the abnormalities of midline brain structures with the psychiatric illness

Histopathological effects of maternal hair dye use on the cornea

The aim of this study is to investigate and compare the histopathological effects of hair dye additives, 2-amino-5-nitrophenol (2A5NP) and 2-nitro-p-phenylendiamin (2NPPD) on cornea of neonates from pregnant rats that have been administered these additives subcutaneously. The study included 90 neonates of 26 nulligravida wistar-albino rats among which ten were given 100 mg/kg/day 2A5NP (Group I), ten rats received 150 mg/kg/day 2NPPD (Group II) and control rats received saline (Group III) injections subcutaneously between 7th and 15th gestational days. No sign of toxicity was observed during the treatment and there was no gross abnormality in both the study and control groups. Histopathological changes of cornea were seen in 22 of 30 newborn rats in Group I (73.4%), in 23 of 30 rats in Group II (76.7%) and only 5 of 30 rats in the control saline injected Group III (16.7%). Histopathological effect of the two additives were statistically significant when compared to the control group (Chi-square: 27.63, p = 0.0001), but there was no difference between the effects of 2A5NP and 2NPPD additives on cornea (Chisquare:0.089, p = 0.766). The present experimental study on rats confirmed the histopathological effect of 2A5NP and 2NPPD on cornea beyond doubt. In the light of which, we can speculate that maternal exposure of hair dyes during pregnancy has some teratogenic effects on newborn rat cornea

Picturing asthma in Turkey: results from the Turkish adult asthma registry

Introduction: National data on asthma characteristics and the factors associated with uncontrolled asthma seem to be necessary for every country. For this purpose, we developed the Turkish Adult Asthma Registry for patients with asthma aiming to take a snapshot of our patients, thereby assigning the unmet needs and niche areas of intervention. Methods: Case entries were performed between March 2018 and March 2022. A web-based application was used to record data. Study outcomes were demographic features, disease characteristics, asthma control levels, and phenotypes. Results: The registry included 2053 patients from 36 study centers in Turkey. Female subjects dominated the group (n = 1535, 74.8%). The majority of the patients had allergic (n = 1158, 65.3%) and eosinophilic (n = 1174, 57.2%) asthma. Six hundred nineteen (32.2%) of the patients had obese asthma. Severe asthma existed in 670 (32.6%) patients. Majority of cases were on step 3–5 treatment (n: 1525; 88.1%). Uncontrolled asthma was associated with low educational level, severe asthma attacks in the last year, low FEV1, existence of chronic rhinosinusitis and living in particular regions. Conclusion: The picture of this registry showed a dominancy of middle-aged obese women with moderate-to-severe asthma. We also determined particular strategic targets such as low educational level, severe asthma attacks, low FEV1, and chronic rhinosinusitis to decrease uncontrolled asthma in our country. Moreover, some regional strategies may also be needed as uncontrolled asthma is higher in certain regions. We believe that these data will guide authorities to reestablish national asthma programs to improve asthma service delivery