: Repenser les circulations des hommes, des œuvres, des savoir-faire et des modèles

International audienc

[ICU acquired neuromyopathy].

International audienceICU acquired neuromyopathy (IANM) is the most frequent neurological pathology observed in ICU. Nerve and muscle defects are merged with neuromuscular junction abnormalities. Its physiopathology is complex. The aim is probably the redistribution of nutriments and metabolism towards defense against sepsis. The main risk factors are sepsis, its severity and its duration of evolution. IANM is usually diagnosed in view of difficulties in weaning from mechanical ventilation, but electrophysiology may allow an earlier diagnosis. There is no curative therapy, but early treatment of sepsis, glycemic control as well as early physiotherapy may decrease its incidence. The outcomes of IANM are an increase in morbi-mortality and possibly long-lasting neuromuscular abnormalities as far as tetraplegia

Rate of ratio normalization in INSTI- or Non INSTI-containing regimens.

<p>Rate of ratio normalization in INSTI- or Non INSTI-containing regimens.</p

Selection of study participants.

<p>Selection of study participants.</p

Predictors of achieving a CD4/CD8 ratio >1.

<p>Abbreviations—OR, odd-ratio; 95%CI, 95% confidence interval; p, p-value; BMI, body mass index; NRTI, nucleos(t)ide reverse transcriptase inhibitor; NNRTI, non-nucleotide reverse transcriptase inhibitor; PI, protease inhibitor; II, integrase inhibitor; EI, entry inhibitor.</p><p>Multivariate model 1 considered cART treatment as a 4 classes variable, multivariable model 2 considered cART treatment as binary variable II containing regimen or not.</p><p>Predictors of achieving a CD4/CD8 ratio >1.</p

Baseline characteristics of the study population.

<p>Abbreviations—cART, combined antiretroviral therapy; sd, standard deviation; IQR, interquartile range. incl, including.</p><p>Baseline characteristics of the study population.</p