El neolítico en las comarcas centro-meridionales valencianas: matices sobre el modelo dual

Es mostren les peculiaritats de la manera de viure les comunitats neolítiques de les terres centromeridionals del País Valencià. Des de la versió tradicional del model dual s’ha intentat donar una visió del procés de neolitització basat en una tendència constant i progressiva de consolidació del mode de vida agrícola i ramader. En canvi, l’anàlisi detallada del mode de vida d’aquestes comunitats indica una evolució més complexa, que tan sols en part respon a aquesta tendència. Paraules clau: Neolític. Model dual. Mode de vida mixt. Formes de treball. Produccions simbòliques.In this paper we show the peculiarities in the way of life of the neolithic communities in the middle and southern Pais Valencià (Spain). The usual version of the dual model dwells of the assumption that there is a constant and progressive tendency to consolidating the farming economy. However, the detailed analysis of the way of life of these communities indicates that the social evolution may have been much more complex. Key words: Neolithic. Dual model. Mixed way of life. Modes of labour. Symbolic productions.A lo largo de estas páginas queremos mostrar las peculiaridades del modo de vida de las comunidades neolíticas de las tierras centro-meridionales del País Valenciano. Desde la versión tradicional del modelo dual se ha intentado dar una visión del proceso de neolitización basada en una tendencia constante y progresiva de consolidación del modo de vida agrícola y ganadero. En cambio, el análisis detallado del modo de vida de estas comunidades indica una evolución más compleja, que sólo en parte responde a esta tendencia. Palabras Clave: Neolítico. Modelo dual. Modo de vida mixto. Modos de trabajo. Producciones simbólicas

Two Neolithic structures at the archaeological site of Casa Garrido Nord II (Moixent, Valencia)

Es presenten les restes de cronologia neolítica documentades a les obres de canalització de gas a la vall de Montesa. Concretament, dues sitges del Neolític II de la seqüència regional, aparegudes al jaciment de Casa Garrido Nord, al terme municipal de Moixent. Encara que els materials són poc significatius, es tracta de les primeres estructures de cronologia neolítica, de les quals tenim constància, en què s’ha realitzat una excavació arqueològica sistemàtica a la comarca de la Costera. Paraules clau: Casa Garrido Nord II. Sitja. Neolític II. La Costera. Assentaments en pla.Es presenten les restes de cronologia neolítica documentades a les obres de canalització de gas a la vall de Montesa. Concretament, dues sitges del Neolític II de la seqüència regional, aparegudes al jaciment de Casa Garrido Nord, al terme municipal de Moixent. Encara que els materials són poc significatius, es tracta de les primeres estructures de cronologia neolítica, de les quals tenim constància, en què s’ha realitzat una excavació arqueològica sistemàtica a la comarca de la Costera. Paraules clau: Casa Garrido Nord II. Sitja. Neolític II. La Costera. Assentaments en pla.Herewith we submit the remains of Neolithic chronology found at the gas piping works performed at the Valley of Montesa (Valencia). They are specifically two Neolithic II underground storage places of a regional sequence, which appeared at the Casa Garrido Nord archaeological site, within the Moixent municipal borough (in the province of Valencia). Although the materials are not very meaningful, they represent the first structures of Neolithic chronology known to us, and therefore we have carried out a systematic archaeological excavation in the area of La Costera (Valencia). Key words: Casa Garrido Nord II. Silo. Neolithic II. La Costera. Settlements on flat lands

IgG4 autoantibodies are inhibitory in the autoimmune disease bullous pemphigoid

The IgG4 subclass of antibodies exhibits unique characteristics that suggest it may function in an immunoregulatory capacity. The inhibitory function of IgG4 has been well documented in allergic disease by the demonstration of IgG4 blocking antibodies, but similar functions have not been explored in autoimmune disease. Bullous pemphigoid (BP) is a subepidermal autoimmune blistering disease characterized by autoantibodies directed against BP180 and an inflammatory infiltrate including eosinophils and neutrophils. Animal models have revealed that the NC16A region within BP180 harbors the critical epitopes necessary for autoantibody mediated disease induction. BP180 NC16A-specific IgG belong to the IgG1, IgG3, and IgG4 subclasses. The purpose of this study was to determine effector functions of different IgG subclasses of NC16A-specific autoantibodies in BP. We find that IgG4 anti-NC16A autoantibodies inhibit the binding of IgG1 and IgG3 autoantibodies to the NC16A region. Moreover, IgG4 anti-NC16A blocks IgG1 and IgG3 induced complement fixation, neutrophil infiltration, and blister formation clinically and histologically in a dose-dependent manner following passive transfer to humanized BP180-NC16A mice. These findings highlight the inhibitory role of IgG4 in autoimmune disease and have important implications for the treatment of BP as well as other antibody mediated inflammatory and autoimmune diseases

Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients

Atopic dermatitis; Memory T cells; PruritusDermatitis atòpica; Cèl·lules T de memòria; PruritDermatitis atópica; Células T de memoria; PruritoBackground: The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical context of atopic dermatitis (AD) has not been characterized. Methods: The response to house dust mite (HDM) in purified memory T cells cocultured with epidermal cells from AD patients (n=58) and control subjects (n=11) was evaluated. AD-associated cytokines from culture supernatants, plasma proteins and mRNA expression from cutaneous lesions were assessed and related with the clinical features of the patients. Results: HDM-induced IL-31 production by memory T cells defined two subsets of AD patients according to the presence or absence of IL-31 response. Patients in the IL-31 producing group showed a more inflammatory profile, and increased HDM-specific (sp) and total IgE levels compared to the IL-31 non-producing group. A correlation between IL-31 production and patient's pruritus intensity, plasma CCL27 and periostin was detected. When the same patients were analyzed based on sp IgE and total IgE levels, an increased IL-31 in vitro response, as well as type 2 markers in plasma and cutaneous lesions, was found in patients with sp IgE levels > 100 kUA/L and total IgE levels > 1000 kU/L. The IL-31 response by memory T cells was restricted to the cutaneous lymphocyte-associated antigen (CLA)+ T-cell subset. Conclusion: IgE sensitization to HDM allows stratifying IL-31 production by memory T cells in AD patients and relating it to particular clinical phenotypes of the disease

Cutaneous Apocrine Adenocarcinoma of the Groin With Extramammary Paget Disease: Response to Dual HER2 Blockade With Trastuzumab and Pertuzumab

Adenocarcinoma apocrino cutáneo; Enfermedad de Paget extramamaria; TratamientoAdenocarcinoma apocri cutani; Malaltia de Paget extramamària; TractamentCutaneous apocrine adenocarcinoma; Extramammary Paget's disease; TreatmentEl carcinoma apocrino cutáneo es una neoplasia maligna rara que se asocia a mal pronóstico. La enfermedad de Paget extramamaria (EPEM) invasiva es una forma rara de adenocarcinoma que se observa principalmente en las áreas donde se encuentran las glándulas apocrinas y tiene un pronóstico peor que su estadio in situ con un riesgo mayor de neoplasias subyacentes. La diseminación epidérmica pagetoide es poco común en los carcinomas apocrinos. Se han descrito muy pocos casos que asocien estas dos entidades y se desconoce su histogénesis. Entre un 20 y un 60% de EPEM sobreexpresa HER-2/neu (c-erbB-2), con pocos casos descritos de respuesta favorable a trastuzumab (anticuerpo monoclonal recombinante contra HER-2), solo o en combinación con paclitaxel. La sobreexpresión de HER-2/neu conduce a una proliferación aumentada de las células tumorales en la EPEM, como en los cánceres de mama HER2 positivos, de comportamiento más agresivo y más recurrències

SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis

Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infectionsDermatitis atópica; Antígeno cutáneo de linfocitos; Infecciones de la pielDermatitis atòpica; Antigen limfòcit cutani; Infeccions de la pellStaphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients

Las primeras comunidades agropecuarias del Río Vinalopó (Alicante)

Se sintetiza la documentación empírica disponible sobre el poblamiento neolítico en la cuenca del río Vinalopó (Alicante, España). Al mismo tiempo se propone una hipótesis de trabajo sobre el proceso histórico a escala regional.We synthesise the empirical information about Neolithic settlements in Vinalopó Valley (Alicante, Spain). At the same time, we propose a work hypothesis about historical development at regional scale

Outbreak of Dermatophyte Infections on the Head and Neck Related to Shave Haircuts: Description of a Multicenter Case Series

Tinea capitis; Brote; PeluqueríasTinea capitis; Outbreak; HairdresserTinea capitis; Brot; PerruqueriesIntroduction: Since 2021, an increase in cases of tinea capitis has been detected in adolescents who shave their hair with fade haircut. Patients and methods: Multicenter retrospective observational study of cases of cephalic pole dermatophytosis with a history of having been acquired after frequent shaving in hairdressing. A call was made to dermatologists from the Spanish Academy of Dermatology and Venereology (AEDV) to provide cases observed between January 2021 and December 2022. Patients with microbiological confirmation by culture or direct examination with KOH were included. Results: 107 cases were collected, 106 of which were male. 78 non-inflammatory forms were observed, compared to 29 inflammatory. The most frequently isolated fungus was Trichophyton tonsurans (75.7% of cases). The lesions appeared predominantly on the nape of the neck and temporal area. Conclusions: The distribution by sex, age and lesional location seems to indicate that a new social trend, in which male adolescents regularly go to hairdressers to shave the occipital and temporal areas, would be the cause of this grouping of cases of ringworm of the scalp. The most frequent microorganism in our study (T.tonsurans) coincides with the most prevalent in our environment. This study shows an accumulation of cases that can be taken into account by competent Public Health agencies, which are responsible for ensuring compliance with the rules of disinfection of the material used for shaving.Introducción: Desde 2021 se ha detectado un aumento de casos de tiñas del cuero cabelludo en adolescentes que se cortan el pelo mediante rasurado o degradado. Pacientes y métodos: Estudio observacional retrospectivo multicéntrico de casos de dermatofitosis del polo cefálico con el antecedente de haber sido contraídas tras el rasurado frecuente en peluquería. Se realizó una llamada a dermatólogos de la Academia Española de Dermatología y Venereología (AEDV) para que aportaran casos observados entre enero de 2021 y diciembre de 2022. Se incluyeron pacientes con confirmación microbiológica mediante cultivo o examen directo con KOH. Resultados: Se recogieron 107 casos, siendo 106 pacientes varones. Se observaron 78 formas no inflamatorias frente a 29 inflamatorias. El hongo aislado con mayor frecuencia fue Trichophyton tonsurans (75,7% de los casos). Las lesiones aparecieron predominantemente en la nuca y en el área temporal. Conclusiones La distribución por sexo, edad y localización lesional parece apuntar a que una nueva tendencia social, en la que adolescentes varones acuden asiduamente a peluquerías para el afeitado de las zonas occipital y temporal, sería la causante de esta agrupación de casos de tiña del cuero cabelludo. El microorganismo más frecuente en nuestro estudio (T. tonsurans) coincide con el más prevalente en nuestro medio. Con el presente estudio se evidencia un acúmulo de casos susceptible de ser tenido en cuenta por organismos competentes de salud pública, a los cuales corresponde velar por el cumplimiento de las normas de desinfección del material empleado para el rasurado

Vocabulario de la enfermedad por el virus del ébola (EN-ES)

Se trata de un estudio terminológico sistemático sobre la enfermedad por el virus del Ébola (Ebola virus disease)

Healthcare experience and their relationship with demographic, disease and healthcare-related variables: a cross-sectional survey of patients with chronic diseases using the IEXPAC scale.

[Abstract] BACKGROUND: Patient experience is acknowledged as a principal aspect of quality healthcare delivery, and it has implications with regard to outcomes. OBJECTIVES: Our objective was to evaluate the healthcare experience of patients with chronic diseases to identify patient-perceived healthcare gaps and to assess the influence of demographic and healthcare-related variables on patient experiences. METHODS: A cross-sectional survey was delivered to adult patients with chronic diseases: diabetes mellitus (DM), human immunodeficiency virus (HIV) infection, inflammatory bowel disease (IBD) or rheumatic diseases. Patient experiences were assessed with the Instrument for Evaluation of the Experience of Chronic Patients (IEXPAC) questionnaire, with possible scores ranging from 0 (worst) to 10 (best experience). RESULTS: Of the 2474 patients handed the survey, 1618 returned it (response rate 65.4%). Patients identified gaps in healthcare related mainly to access to reliable information and services, interaction with other patients and continuity of healthcare after hospital discharge. The mean ± standard deviation (SD) IEXPAC score was 6.0 ± 1.9 and was higher for patients with HIV (6.6 ± 1.7) than for those with rheumatic disease (5.5 ± 2.0), IBD (5.9 ± 2.0) or DM (5.9 ± 1.9) (p < 0.001). In multivariate models, better overall IEXPAC experience was associated with follow-up by the same physician, follow-up by a nurse, receiving healthcare support from others and treatment with subcutaneous or intravenous drugs. The multivariate model that confirmed patients with HIV or DM had better experience than did those with rheumatic diseases. CONCLUSIONS: Through IEXPAC, patients identified aspects for healthcare quality improvements and circumstances associated with better experience, which may permit greater redirection of healthcare toward patient-centered goals while facilitating improvements in social care and long-term healthcare quality