Tracking Cluster Debris (TraCD) – I. Dissolution of clusters and searching for the solar cradle

The capability to reconstruct dissolved stellar systems in dynamical and chemical space is a key factor in improving our understanding of the evolution of the Milky Way. Here we concentrate on the dynamical aspect and given that a significant portion of the stars in the Milky Way have been born in stellar associations or clusters that have lived a few Myr up to several Gyr, we further restrict our attention to the evolution of star clusters. We have carried out our simulations in two steps: (1) we create a simulation of dissolution and mixing processes which yields a close fit to the present-day Milky Way dynamics and (2) we have evolved three sets of stellar clusters with masses of 400, 1000 and 15 000 M⊙ to dissolution. The birth location of these sets was 4, 6, 8 and 10 kpc for the 400 and 1000 M⊙ clusters and 4, 6, 8, 10 and 12 kpc for the 15 000 M⊙. We have focused our efforts on studying the state of the escapers from these clusters after 4.5 Gyr of evolution with particular attention to stars that reach the solar annulus, i.e. 7.5 ≤ Rgc ≤ 8.5 kpc. We give results for solar twins and siblings over a wide range of radii and cluster masses for two dissolution mechanisms. From kinematics alone, we conclude that the Sun was ∼50 per cent more likely to have been born near its current Galactocentric radius, rather than have migrated (radially) ∼2 kpc since birth. We conclude our analysis by calculating magnitudes and colours of our single stars for comparison with the samples that the Gaia, Gaia-ESO and GALAH-AAO surveys will obtain. In terms of reconstructing dissolved star clusters, we find that on short time-scales we cannot rely on kinematic evolution alone and thus it will be necessary to extend our study to include information on chemical space

Operatives und Nichtoperatives Management von Abdomianlverletzungen beim Polytrauma : meeting abstract

Einleitung: Die Behandlung stumpfer abdomineller Verletzungen hat sich innerhalb der letzten Jahre zugunsten der konservativen Therapie gewandelt. Die Untersuchung beschäftigt sich mit der Frage, ob nichtoperatives Management von Abdominalverletzungen eine sichere und in der Routine praktikable therapeutische Option darstellt und wie häufig eine Konversion von primär konservativen zu operativen Management durchgeführt werden muß. Methodik: In einem Zeitraum von 3 Jahren (September 2002 bis August 2005) wurden 1214 Patienten über den Schockraum der Uniklinik Frankfurt aufgenommen. Die Datenerhebung und der Behandlungsverlauf erfolgte prospektiv on-line über den gesamten Behandlungsverlauf mittels des on-line Dokumentationsprogrammes Traumawatch´. Ergebnisse: Der durchschnittliche ISS aller Patienten lag bei 15. Eine relevante abdominelle Beteiligung (AIS >3) bestand in 12,4% der Fälle (151 Patienten) mit einem mittleren ISS von 33. Es wurden 60 Leberverletzungen (39,7%), 50 Milzverletzungen (33,1%), Verletzungen des Darms und Mesenterium in 19 Fällen (12,6%), 15 Verletzungen der Niere und der Harnwege(9,9 %) und Verletzungen Bauchdecke bei 28 Patienten (18,5 %) festgestellt. Das Pankreas war bei 3 Patienten (2,0%) und das Zwerchfell bei 8 Patienten (5,3%) betroffen. In 77 Fällen (51%) wurden die Patienten mit Abdominaltrauma primär konservativ, in 74 Fällen (49%) operativ versorgt, 10 Patienten (7%) wurden laparoskopiert. Nur bei 2 Patienten (1,3%) musste eine Konversion von der primär konservativen Therapie in eine operative erfolgen. Es handelte sich hierbei um eine sekundäre Darmperforation und eine zweizeitige Milzruptur. Patienten mit einer Leberverletzung konnten in 65% der Fälle konservativ versorgt werden, Patienten mit Milzverletzung hingegen nur in 50% der Fälle. 32% der operierten Patienten wurden splenektomiert. 4 Patienten, alle mit einem AIS-Abdomen größer oder gleich 4, verstarben im Schockraum noch vor operativer Interventionsmöglichkeit. Schlussfolgerung: Nichtoperatives Vorgehen beim Polytrauma mit abdomineller Beteiligung ist bei hämodynamisch stabilem Patienten weitgehend sicher möglich. Insbesondere für Leberverletzungen bis einem Schweregrad Moore V stellt das primär konservatives Vorgehen eine geeignete therapeutische Option dar

Rotational Extension Promotes Coeval Upper Crustal Brittle Faulting and Deep‐Seated Rift‐Axis Parallel Flow: Dynamic Coupling Processes Inferred From Analog Model Experiments

The lower parts of warm, thick continental crust can flow in a ductile fashion to accommodate thinning of the upper brittle crust during extension. Naturally occurring continental rifts with a rift-axis parallel deformation gradient imply an underlying rotational component. In such settings, rift-parallel crustal flow transports material perpendicular to the direction of rifting. We use analogue experiments to investigate rotational rifting and coeval crustal flow. To test the effect of rift-axis parallel flow on rift evolution, we use different gravitational loads resulting in a range of horizontal pressure gradient magnitudes which drive horizontal lower-crustal flow. The use of (three dimensional) 3D Digital Volume Correlation techniques on X-Ray CT data combined with 3D Digital Image Correlation techniques applied to topographic stereo images provides detailed insights on the contemporaneous evolution of ductile flow patterns and brittle rift structures, respectively. Our results depict a complex flow field in the ductile lower crust during rotational rifting with: (a) extension-parallel horizontal inward flow and vertical upward flow that compensates thinning of the brittle upper crustal layer; (b) rift-axis parallel lateral flow, that compensates greater amounts of thinning further away from the rotation axis; and (c) different degrees of mechanical coupling between the brittle and viscous layers that change during rift propagation. Our analogue experiments provide insights into ductile lower crustal flow patterns during rift evolution. The results emphasize the three dimensionality of rifting, which is an important effect that should be considered when estimating the amount of crustal extension from two dimensional (2D) cross sections

Adaptive Input and Parameter Estimation with Application to Engine Torque Estimation

This paper presents two estimation methods for systems with unknown time-varying input dynamics. By defining auxiliary filtered variables, an invariant manifold is derived and used to drive the input estimator with only one tuning parameter. Exponential error convergence to a small compact set around theorigin can be proved. Robustness against noise is studied and compared with two well-known schemes. Moreover, when the input dynamics to be estimated are parameterized in a quasilinear form with unknown parameters, the proposed idea is further investigated to estimate the associated unknowntime-varying parameters. The algorithms are tested by considering the torque estimation of internal combustion engines (ICEs). Comparative simulation results based on a benchmark engine simulation model show satisfactory transient androbustness performance

Output Feedback Speed Control for a Wankel Rotary Engine via Q-Learning

This paper develops a dynamic output feedback controller based on continuous-time Q-learning for the engine speed regulation problem. The proposed controller is able to learn the optimal control solution online in a finite time using only the measurable outputs. We first present the mean value engine model (MVEM) for a Wankel rotary engine. The regulation of engine speed can be formulated as an optimal control problem that minimises a pre-defined value function by actuating the electronic throttle. By parameterising an action-dependent Q-function, we derive a full-state adaptive optimal feedback controller using the idea of continuous-time Q-learning. The adaptive critic approximates the Q-function as a neural network and directly updates the actor, where the convergence is guaranteed by employing novel finite-time adaptation techniques. Then, we incorporate the extended Kalman filter (EKF) as an optimal reduced-order state observer, which enables the online estimation of the unknown fuel puddle dynamics, to achieve a dynamic output feedback engine speed controller. The simulation results of a benchmark 225CS engine demonstrate that the proposed controller can effectively regulate the engine speed to a set point under certain load disturbances

Influence of chronic azithromycin treatment on the composition of the oropharyngeal microbial community in patients with severe asthma

Background: This study of the oropharyngeal microbiome complements the previously published AZIthromycin in Severe ASThma (AZISAST) clinical trial, where the use of azithromycin was assessed in subjects with exacerbationprone severe asthma. Here, we determined the composition of the oropharyngeal microbial community by means of deep sequencing of the amplified 16S rRNA gene in oropharyngeal swabs from patients with exacerbationprone severe asthma, at baseline and during and after 6 months treatment with azithromycin or placebo. Results: A total of 1429 OTUs were observed, of which only 59 were represented by more than 0.02% of the reads. Firmicutes, Bacteroidetes, Fusobacteria, Proteobacteria and Actinobacteria were the most abundant phyla and Streptococcus and Prevotella were the most abundant genera in all the samples. Thirteen species only accounted for two thirds of the reads and two species only, i.e. Prevotella melaninogenica and Streptococcus mitis/pneumoniae, accounted for one fourth of the reads. We found that the overall composition of the oropharyngeal microbiome in patients with severe asthma is comparable to that of the healthy population, confirming the results of previous studies. Long term treatment (6 months) with azithromycin increased the species Streptococcus salivarius approximately 5-fold and decreased the species Leptotrichia wadei approximately 5-fold. This was confirmed by Boruta feature selection, which also indicated a significant decrease of L. buccalis/L. hofstadtii and of Fusobacterium nucleatum. Four of the 8 treated patients regained their initial microbial composition within one month after cessation of treatment. Conclusions: Despite large diversity of the oropharyngeal microbiome, only a few species predominate. We confirm the absence of significant differences between the oropharyngeal microbiomes of people with and without severe asthma. Possibly, long term azithromycin treatment may have long term effects on the composition of the oropharygeal microbiome in half of the patients