Spin dynamics of heterometallic Cr7M wheels (M = Mn, Zn, Ni) probed by inelastic neutron scattering

Inelastic neutron scattering has been applied to the study of the spin dynamics of Cr-based antiferromagnetic octanuclear rings where a finite total spin of the ground state is obtained by substituting one Cr(III) ion (s = 3/2) with Zn (s = 0), Mn (s = 5/2) or Ni (s = 1) di-cations. Energy and intensity measurements for several intra-multiplet and inter-multiplet magnetic excitations allow us to determine the spin wavefunctions of the investigated clusters. Effects due to the mixing of different spin multiplets have been considered. Such effects proved to be important to correctly reproduce the energy and intensity of magnetic excitations in the neutron spectra. On the contrary to what is observed for the parent homonuclear Cr8 ring, the symmetry of the first excited spin states is such that anticrossing conditions with the ground state can be realized in the presence of an external magnetic field. Heterometallic Cr7M wheels are therefore good candidates for macroscopic observations of quantum effects.Comment: 9 pages, 11 figures, submitted to Phys. Rev. B, corrected typos and added references, one sentence change

A chi-squared time-frequency discriminator for gravitational wave detection

Searches for known waveforms in gravitational wave detector data are often done using matched filtering. When used on real instrumental data, matched filtering often does not perform as well as might be expected, because non-stationary and non-Gaussian detector noise produces large spurious filter outputs (events). This paper describes a chi-squared time-frequency test which is one way to discriminate such spurious events from the events that would be produced by genuine signals. The method works well only for broad-band signals. The case where the filter template does not exactly match the signal waveform is also considered, and upper bounds are found for the expected value of chi-squared.Comment: 18 pages, five figures, RevTex

Bound states and field-polarized Haldane modes in a quantum spin ladder

The challenge of one-dimensional systems is to understand their physics beyond the level of known elementary excitations. By high-resolution neutron spectroscopy in a quantum spin ladder material, we probe the leading multiparticle excitation by characterizing the two-magnon bound state at zero field. By applying high magnetic fields, we create and select the singlet (longitudinal) and triplet (transverse) excitations of the fully spin-polarized ladder, which have not been observed previously and are close analogs of the modes anticipated in a polarized Haldane chain. Theoretical modelling of the dynamical response demonstrates our complete quantitative understanding of these states.Comment: 6 pages, 3 figures plus supplementary material 7 pages 5 figure

Continuous niobium phosphate catalysed Skraup reaction for quinoline synthesis from solketal

Solketal is derived from the reaction of acetone with glycerol, a by-product product of the biodiesel industry. We report here the continuous reaction of solketal with anilines over a solid acid niobium phosphate (NbP), for the continuous generation of quinolines in the the well-established Skraup reaction. This study shows that NbP can catalyse all stages of this multistep reaction at 250 °C and 10 MPa pressure, with a selectivity for quinoline of up to 60%. We found that the catalyst eventually deactivates, most probably via a combination of coking and reduction processes but nevertheless we show the promise of this approach. We demonstrated here the application of our approach to synthesize both mono- and bis-quinolines from the commodity chemical, 4,4’-methylenedianiline

Channeling and Volume Reflection Based Crystal Collimation of Tevatron Circulating Beam Halo (T-980)

The T980 crystal collimation experiment is underway at the Tevatron to determine if this technique could increase 980 GeV beam-halo collimation efficiency at high-energy hadron colliders such as the Tevatron and the LHC. T980 also studies various crystal types and parameters. The setup has been substantially enhanced during the Summer 2009 shutdown by installing a new O-shaped crystal in the horizontal goniometer, as well as adding a vertical goniometer with two alternating crystals (O-shaped and multi-strip) and additional beam diagnostics. First measurements with the new system are quite encouraging, with channeled and volume-reflected beams observed on the secondary collimators as predicted. Investigation of crystal collimation efficiencies with crystals in volume reflection and channeling modes are described in comparison with an amorphous primary collimator. Results on the system performance are presented for the end-of-store studies and for entire collider stores. The first investigation of colliding beam collimation simultaneously using crystals in both the vertical and horizontal plane has been made in the regime with horizontally channeled and vertically volume-reflected beams. Planning is underway for significant hardware improvements during the FY10 summer shutdown and for dedicated studies during the final year of Tevatron operation and also for a "post-collider beam physics running" period.Comment: 3 pp. 1st International Particle Accelerator Conference: IPAC'10, 23-28 May 2010: Kyoto, Japa

Crystal experiments on efficient beam extraction

Silicon crystal was channeling and extracting 70-GeV protons from the U-70 accelerator with efficiency of 85.3+-2.8% as measured for a beam of 10^12 protons directed towards crystals of 2 mm length in spills of 1-2 s duration. The experimental data follow very well the prediction of Monte Carlo simulations. This success is important to devise a more efficient use of the U-70 accelerator in Protvino and provides a crucial support for implementation of crystal-assisted collimation of gold ion beam in RHIC and slow extraction from AGS onto E952, now in preparation at Brookhaven Nat'l Lab. Future applications, spanning in the energy from sub-GeV (medical) to order of 1 GeV (scraping in the SNS, extraction from COSY) to order of 1 TeV and beyond (scraping in the Tevatron, LHC, VLHC), can benefit from these studies.Comment: 12pp. Presented at 19-th Intern. Conference on Atomic Collisions in Solids (ICACS-19: Paris, July 29 - August 3, 2001

Progress in crystal extraction and collimation

Recent IHEP Protvino experiments show efficiencies of crystal-assisted slow extraction and collimation of 85.3+-2.8%, at the intensities of the channeled beam on the order of 10^12 proton per spill of 2 s duration. The obtained experimental data well follows the theory predictions. We compare the measurements against theory and outline the theoretical potential for further improvement in the efficiency of the technique. This success is important for the efficient use of IHEP accelerator and for implementation of crystal-assisted collimation at RHIC and slow extraction from AGS onto E952, now in preparation. Future applications, spanning in the energy from order of 1 GeV (scraping in SNS, slow extraction from COSY and medical accelerators) to order of 1 TeV and beyond (scraping in Tevatron, LHC, VLHC), can benefit from these studies.Comment: 7pp. Presented at HEACC 2001 (Tsukuba, March 25-30

Mending a broken heart by biomimetic 3D printed natural biomaterial-based cardiac patches: a review

: Myocardial infarction is one of the major causes of mortality as well as morbidity around the world. Currently available treatment options face a number of drawbacks, hence cardiac tissue engineering, which aims to bioengineer functional cardiac tissue, for application in tissue repair, patient specific drug screening and disease modeling, is being explored as a viable alternative. To achieve this, an appropriate combination of cells, biomimetic scaffolds mimicking the structure and function of the native tissue, and signals, is necessary. Among scaffold fabrication techniques, three-dimensional printing, which is an additive manufacturing technique that enables to translate computer-aided designs into 3D objects, has emerged as a promising technique to develop cardiac patches with a highly defined architecture. As a further step toward the replication of complex tissues, such as cardiac tissue, more recently 3D bioprinting has emerged as a cutting-edge technology to print not only biomaterials, but also multiple cell types simultaneously. In terms of bioinks, biomaterials isolated from natural sources are advantageous, as they can provide exceptional biocompatibility and bioactivity, thus promoting desired cell responses. An ideal biomimetic cardiac patch should incorporate additional functional properties, which can be achieved by means of appropriate functionalization strategies. These are essential to replicate the native tissue, such as the release of biochemical signals, immunomodulatory properties, conductivity, enhanced vascularization and shape memory effects. The aim of the review is to present an overview of the current state of the art regarding the development of biomimetic 3D printed natural biomaterial-based cardiac patches, describing the 3D printing fabrication methods, the natural-biomaterial based bioinks, the functionalization strategies, as well as the in vitro and in vivo applications

Isavuconazole for the treatment of fungal infections: a real-life experience from the Fungal Infection Network of Switzerland (FUNGINOS)

This analysis of 116 isavuconazole therapy courses shows that hepatic test disturbances (HTD) were relatively frequent (29% cases), but rarely led to treatment interruption (5%). Importantly, patients with baseline HTD, including those attributed to a first-line triazole, did not exhibit a higher risk of subsequent HTD under isavuconazole therapy