Generalized Young equation for a spherical droplet inside a smooth and homogeneous cone involved by quadratic parabola

We thermodynamically investigate the wetting characteristics of a spherical droplet in a smooth and homogeneous cone rotated by the quadratic parabola through the mechanisms of both Gibbs’s dividing surfaces and Rusanov’s dividing line. For the triple phase system including the solid, liquid and vapor phases, the derivation of a generalized Young equation containing the influences of the line tension is successfully carried out. Additionally, we as well analyze various approximate forms for this generalized Young equation by using the corresponding assumptions

Generalized Cassie-Baxter equation for wetting of a spherical droplet within a smooth and heterogeneous conical cavity

Introducing the concepts of both Gibbs’s dividing surface and Rusanov’s dividing line, the wettability behaviors of spherical drops inside a smooth and heterogeneous conical cavity are studied. A new generalized Cassie-Baxter equation for contact angles including the influences of the line tension is derived thermodynamically. Additionally, various approximate formulae of this generalized Cassie-Baxter equation are also discussed correspondingly under some assumptions

Hamiltonian type Lie bialgebras

We first prove that, for any generalized Hamiltonian type Lie algebra $L$, the first cohomology group $H^1(L,L \otimes L)$ is trivial. We then show that all Lie bialgebra structures on $L$ are triangular.Comment: LaTeX, 16 page

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Ubiquitin-specific protease 19 (USP19) is one of the deubiquitinating enzymes (DUBs) involved in regulating the ubiquitination status of substrate proteins. There are two major isoforms of USP19 with distinct C-termini; the USP19_a isoform has a transmembrane domain for anchoring to the endoplasmic reticulum, while USP19_b contains an EEVD motif. Here, we report that the cytoplasmic isoform USP19_b up-regulates the protein levels of the polyglutamine (polyQ)-containing proteins, ataxin-3 (Atx3) and huntingtin (Htt), and thus promotes aggregation of their polyQ-expanded species in cell models. Our data demonstrate that USP19_b may orchestrate the stability, aggregation and degradation of the polyQ-expanded proteins through the heat shock protein 90 (HSP90) chaperone system. USP19_b directly interacts with HSP90 through its N-terminal CS (CHORD and SGT1)/P23 domains. In conjunction with HSP90, the cytoplasmic USP19 may play a key role in triage decision for the disease-related polyQ-expanded substrates, suggesting a function of USP19 in quality control of misfolded proteins by regulating their protein levels

Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1-3 of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study, and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% CI 0.82-0.88; P=7.72x10−20) and rs1642764 at 17p13.1 (per-allele OR= 0.88, 95% CI 0.85-0.91; P=3.10x10−13). rs7447927 is a synonymous single nucleotide polymorphism (SNP) in TMEM173 and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR=1.33, 95% CI 1.22-1.46; P=1.99x10−10). Our joint analysis identified new ESCC susceptibility loci overall as well as a new locus unique to the ESCC high risk Taihang Mountain region

©2004 Journal of Software 软 件 学 报 Texture Constrained Facial Feature Point Tracking

Abstract: In this paper, a facial feature point tracking scheme is proposed by integrating Lucas-Kanade optical flow tracking algorithm and the face alignment statistical model, DAM (direct appearance model), together in a Bayesian framework. The prediction of feature positions from Lucas-Kanade algorithm exploits the inter-frame correlations and accelerates the tracking speed. The texture-shape constraint under DAM improves the localization accuracy and robustness. Experiments show that this method adapts well to the various face movements. It can be used in face recognition or 3D face modeling. Key words: optical flow; feature point localization; feature point tracking; Bayesian posterior probability estimation 摘 要: 将 Lucas-Kanade 光流跟踪算法与人脸特征点定位的统计模 型 DAM(direct appearance model)在 Bayesian 框架下结合起来,提出了视频中人脸特征点定位与跟踪的一种混合模型方法.利 用 Lucas-Kanade 算