Expression and clinical significance of <i>Pax6</i> gene in retinoblastoma

AIM: To discuss the expression and clinical significance of <i>Pax6 </i>gene in retinoblastoma(Rb). <p>METHODS: Totally 15 cases of fresh Rb organizations were selected as observation group and 15 normal retinal organizations as control group. Western-Blot and reverse transcriptase polymerase chain reaction(RT-PCR)methods were used to detect <i>Pax6</i> protein and <i>Pax6 </i>mRNA expressions of the normal retina organizations and Rb organizations. At the same time, Western Blot method was used to detect the <i>Pax6</i> gene downstream MATH5 and BRN3b differentiation gene protein level expression. After the comparison between two groups, the expression and clinical significance of <i>Pax6</i> gene in Rb were discussed. <p>RESULTS: In the observation group, average value of mRNA expression of <i>Pax6</i> gene was 0.99±0.03; average value of <i>Pax6</i> gene protein expression was 2.07±0.15; average value of BRN3b protein expression was 0.195±0.016; average value of MATH5 protein expression was 0.190±0.031. They were significantly higher than the control group, and the differences were statistically significant(<i>P</i><0.05). <p>CONCLUSION: Abnormal expression of <i>Pax6</i> gene is likely to accelerate the occurrence of Rb

Observation of quantum fingerprinting beating the classical limit

Quantum communication has historically been at the forefront of advancements, from fundamental tests of quantum physics to utilizing the quantum-mechanical properties of physical systems for practical applications. In the field of communication complexity, quantum communication allows the advantage of an exponential reduction in the information transmitted over classical communication to accomplish distributed computational tasks. However, to date, demonstrating this advantage in a practical setting continues to be a central challenge. Here, we report an experimental demonstration of a quantum fingerprinting protocol that for the first time surpasses the ultimate classical limit to transmitted information. Ultra-low noise superconducting single-photon detectors and a stable fibre-based Sagnac interferometer are used to implement a quantum fingerprinting system that is capable of transmitting less information than the classical proven lower bound over 20 km standard telecom fibre for input sizes of up to two Gbits. The results pave the way for experimentally exploring the advanced features of quantum communication and open a new window of opportunity for research in communication complexity and testing the foundations of physics.Comment: 19 pages, 4 figure

Comment on Reparametrization Invariance of Quark-Lepton Complementarity

We study the complementarity between quark and lepton mixing angles (QLC), the sum of an angle in quark mixing and the corresponding angle in lepton mixing is $\pi/4$. Experimentally in the standard PDG parametrization, two such relations exist approximately. These QLC relations are accidental which only manifest themselves in the PDG parametrization. We propose reparametrization invariant expressions for the complementarity relations in terms of the magnitude of the elements in the quark and lepton mixing matrices. In the exact QLC limit, it is found that $|V_{us}/V_{ud}| + |V_{e2}/V_{e1}| + |V_{us}/V_{ud}| |V_{e2}/V_{e1}| =1$ and $|V_{cb}/V_{tb}| + |V_{\mu 3}/V_{\tau 3}| +|V_{cb}/V_{tb}|| {V_{\mu 3}}/V_{\tau 3}| =1$. Expressions with deviations from exact complementarity are obtained. Implications of these relations are also discussed.Comment: 5 pages and 1 figure. Implications for recent Daya-Bay neutrino data on theta_{13} discusse

Synthesis and characterization of cobalt hydroxide carbonate nanostructures

Battery-type electrodes of three-dimensional (3D) hierarchical cobalt hydroxide carbonate arrays on Ni foam were fabricated using a hydrothermal method for use in supercapacitors. X-ray diffraction analysis, scanning electron microscopy, and transmission electron microscopy were used to characterize their structures and morphologies. The cobalt hydroxide carbonate synthesized with 10 h reaction time showed the highest specific capacitance (1381 F g−1 at a current density of 2 A g−1) and excellent cycling stability (92% capacitance retention after 5000 cycles). Moreover, its capacitance increased by 33% at 2 A g−1 and by 10% at 20 A g−1 after 5000 charge–discharge cycles. This cobalt hydroxide carbonate composite is a promising candidate for electrochemical energy-related applications

The Experimental Research of the Relationship Between Rock Surface Roughness and PDC Bit Wear

By using rock grinding experiment machine to grinding different groups of rock, Using the electron microscope scanning technology to analysis of the wear profile amplification and Contour arithmetic mean deviation Ra, outline of the root mean square deviation Rq and average roughness parameter R the three surface roughness parameters to measure the new grinding surface roughness, using the PDC diamond compact for further PDC grinding experiments in different roughness of the generated sections. Before and after the grinding experiment calculate the lose weight of PDC diamond compact with electronic balance scales, through the analysis of experimental result data concluded that the degree of wear of PDC bit and the roughness grinding profile had a certain linear relationship in the grinding experiments, namely with the increase of roughness the trend of PDC bit wear was from reducing to increasing, and the wear volume reached its lowest point in a certain roughness parameter. using the scanning electron microscopy to analyze the section of PDC wear, and concluded that the wear mechanism of PDC is mainly abrasive wear ,accompanied by fatigue wear and adhesive wear, the wear process of PDC is the process of cleavage. The better way of diamond abrasion wear is: Diamond from exposing to micro broken to cleavage to fall off in the end. The worst way is diamond directly fall off

Publication trends of primary angle-closure disease during 1991-2022: a bibliometric analysis

AIM: To perform a bibliometric analysis in the field of primary angle-closure disease (PACD) research to characterize current global trends and compare contributions from different countries, institutions, journals, and authors. METHODS: All PACD-related publications from 1991 to 2022 from the Web of Science Core Collection database were extracted. Microsoft Excel and VOSviewer were used to collect publication data, analyze publication trends, and visualize relevant results. RESULTS: A total of 1721 publications with 34 591 citations were identified. China produced the most publications (554) while ranking third in citations (8220 times). The United States contributed the most citations (12 315 times) with publications (362) ranking second. The Investigative Ophthalmology Visual Science was the most productive journal concerning PACD, and Aung Tin was the author with the highest number of publications in the field. Keywords were classified into three clusters, epidemiology and pathogenesis research, optical coherence tomography (OCT) and other imaging examinations, and glaucoma surgery treatment. Genome-wide association, susceptibility loci, OCT, and combined phacoemulsification have become new hot research topics in recent years since 2015. CONCLUSION: China, the United States, and Singapore make the most outstanding contributions in the field of PACD research. OCT, combined phacoemulsification, and gene mutation-related study, are considered the potential focus for future research