Exploring natural products: from herbal resources, microbial synthesis to animal models

Nature serves as a valuable reservoir of resources with significant implications for human health and medicine, holding immense potential and mysteries. Among these resources lies the ancient civilization of Chinese medicine, which boasts a rich heritage spanning five thousand years, yet remains largely unexplored and incompletely understood. Preserving ancestral secret recipes is imperative to harnessing the potential of nature and upholding the legacy of traditional Chinese medicine. This thesis aims to develop a toolkit for unraveling the mechanisms in the near future through existing knowledge of the secret recipe, with a specific focus on investigating the inhibitory effects of flavonoids and terpenoids derived from wild plants on viral envelope synthesis and cholesterol modulation within the body. Thus, shedding light on the treatment of viral hepatitis and non-alcoholic fatty liver disease. The study encompasses three key facets: exploration of plant-based alternatives containing flavonoids and phenolic acids, development of a biotechnological strategy utilizing Bacillus subtilis biosynthesis for the production of squalene and other terpenoids, and the construction and examination of a gerbil model of non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet. These comprehensive investigations have established a combination of robust methodologies, enabling further exploration of secret recipes and the potential of nature in promoting human health

The Formulation of Echo Sounding Correction Tables

The ‘Echo Sounding Correction Tables’ (formerly Matthews’ Tables) are of important practical use to hydrographers, and are convenient to use. In case that there is not any oceanographic data available, the actual depth is derived from the tables with the observed depth from the echo sounder. With the recommendation of the International Hydrographic Organization (IHO) and the Hydrographic Offices of some countries, the tables have been widely used in recent years. Matthews’ tables are suitable for the manual correction of sounding velocity, but not for use by computers. In this paper, the tables are formulated by using the method of the least squares approximation on the basis of the orthogonal system of polynomials. So that only a few simple coefficients need to be entered into the computer, and then the true depth can be calculated directly on the basis of the observed depth data. These correction formulas are very easy and efficient to use, and their accuracy is equivalent to that of the ‘Echo Sounding Correction Tables’

Exploring natural products: from herbal resources, microbial synthesis to animal models

Nature serves as a valuable reservoir of resources with significant implications for human health and medicine, holding immense potential and mysteries. Among these resources lies the ancient civilization of Chinese medicine, which boasts a rich heritage spanning five thousand years, yet remains largely unexplored and incompletely understood. Preserving ancestral secret recipes is imperative to harnessing the potential of nature and upholding the legacy of traditional Chinese medicine. This thesis aims to develop a toolkit for unraveling the mechanisms in the near future through existing knowledge of the secret recipe, with a specific focus on investigating the inhibitory effects of flavonoids and terpenoids derived from wild plants on viral envelope synthesis and cholesterol modulation within the body. Thus, shedding light on the treatment of viral hepatitis and non-alcoholic fatty liver disease. The study encompasses three key facets: exploration of plant-based alternatives containing flavonoids and phenolic acids, development of a biotechnological strategy utilizing Bacillus subtilis biosynthesis for the production of squalene and other terpenoids, and the construction and examination of a gerbil model of non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet. These comprehensive investigations have established a combination of robust methodologies, enabling further exploration of secret recipes and the potential of nature in promoting human health

Exploring natural products: from herbal resources, microbial synthesis to animal models

Nature serves as a valuable reservoir of resources with significant implications for human health and medicine, holding immense potential and mysteries. Among these resources lies the ancient civilization of Chinese medicine, which boasts a rich heritage spanning five thousand years, yet remains largely unexplored and incompletely understood. Preserving ancestral secret recipes is imperative to harnessing the potential of nature and upholding the legacy of traditional Chinese medicine. This thesis aims to develop a toolkit for unraveling the mechanisms in the near future through existing knowledge of the secret recipe, with a specific focus on investigating the inhibitory effects of flavonoids and terpenoids derived from wild plants on viral envelope synthesis and cholesterol modulation within the body. Thus, shedding light on the treatment of viral hepatitis and non-alcoholic fatty liver disease. The study encompasses three key facets: exploration of plant-based alternatives containing flavonoids and phenolic acids, development of a biotechnological strategy utilizing Bacillus subtilis biosynthesis for the production of squalene and other terpenoids, and the construction and examination of a gerbil model of non-alcoholic fatty liver disease induced by a high-fat, high-cholesterol diet. These comprehensive investigations have established a combination of robust methodologies, enabling further exploration of secret recipes and the potential of nature in promoting human health

Numerical Investigation of Characteristic of Anisotropic Thermal Conductivity of Natural Fiber Bundle with Numbered Lumens

Natural fiber bundle like hemp fiber bundle usually includes many small lumens embedded in solid region; thus, it can present lower thermal conduction than that of conventional fibers. In the paper, characteristic of anisotropic transverse thermal conductivity of unidirectional natural hemp fiber bundle was numerically studied to determine the dependence of overall thermal property of the fiber bundle on that of the solid region phase. In order to efficiently predict its thermal property, the fiber bundle was embedded into an imaginary matrix to form a unit composite cell consisting of the matrix and the fiber bundle. Equally, another unit composite cell including an equivalent solid fiber was established to present the homogenization of the fiber bundle. Next, finite element thermal analysis implemented by ABAQUS was conducted in the two established composite cells by applying proper thermal boundary conditions along the boundary of unit cell, and influences of the solid region phase and the equivalent solid fiber on the composites were investigated, respectively. Subsequently, an optional relationship of thermal conductivities of the natural fiber bundle and the solid region was obtained by curve fitting technique. Finally, numerical results from the obtained fitted curves were compared with the analytic Hasselman-Johnson’s results and others to verify the present numerical model