Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth

The outer Solar System object (486958) Arrokoth (provisional designation 2014 MU₆₉) has been largely undisturbed since its formation. We study its surface composition using data collected by the New Horizons spacecraft. Methanol ice is present along with organic material, which may have formed through irradiation of simple molecules. H₂O ice is not detected. This composition indicates hydrogenation of CO-rich ice and/or energetic processing of CH₄+H₂O ices in the cold, outer edge of the early Solar System. There are only small regional variations in color and spectra across the surface, suggesting Arrokoth formed from a homogeneous or well-mixed reservoir of solids. Microwave thermal emission from the winter night side is consistent with a mean brightness temperature of 29 ± 5 K

Color, composition, and thermal environment of Kuiper Belt object (486958) Arrokoth

The outer Solar System object (486958) Arrokoth (provisional designation 2014 MU₆₉) has been largely undisturbed since its formation. We study its surface composition using data collected by the New Horizons spacecraft. Methanol ice is present along with organic material, which may have formed through irradiation of simple molecules. H₂O ice is not detected. This composition indicates hydrogenation of CO-rich ice and/or energetic processing of CH₄+H₂O ices in the cold, outer edge of the early Solar System. There are only small regional variations in color and spectra across the surface, suggesting Arrokoth formed from a homogeneous or well-mixed reservoir of solids. Microwave thermal emission from the winter night side is consistent with a mean brightness temperature of 29 ± 5 K

The ISO LWS high resolution spectral survey towards Sagittarius B2

A full spectral survey was carried out towards the Giant Molecular Cloud complex, Sagittarius B2 (Sgr B2), using the ISO Long Wavelength Spectrometer Fabry-Perot mode. This provided complete wavelength coverage in the range 47-196 um (6.38-1.53 THz) with a spectral resolution of 30-40 km/s. This is an unique dataset covering wavelengths inaccessible from the ground. It is an extremely important region of the spectrum as it contains both the peak of the thermal emission from dust, and crucial spectral lines of key atomic (OI, CII, OIII, NII and NIII) and molecular species (NH3, NH2, NH, H2O, OH, H3O+, CH, CH2, C3, HF and H2D+). In total, 95 spectral lines have been identified and 11 features with absorption depth greater than 3 sigma remain unassigned. Most of the molecular lines are seen in absorption against the strong continuum, whereas the atomic and ionic lines appear in emission (except for absorption in the OI 63 um and CII 158 um lines). Sgr B2 is located close to the Galactic Centre and so many of the features also show a broad absorption profile due to material located along the line of sight. A full description of the survey dataset is given with an overview of each detected species and final line lists for both assigned and unassigned features.Comment: Accepted for publication in MNRA

Real-time analysis of gene regulation by glucocorticoid hormones

There is increasing evidence that temporal factors are important in allowing cells to gain additional information from external factors, such as hormones and cytokines. We sought to discover how cell responses to glucocorticoids develop over time, and how the response kinetics vary according to ligand structure and concentration, and hence have developed a continuous gene transcription measurement system, based on an interleukin-6 (IL-6) luciferase reporter gene. We measured the time to maximal response, maximal response and integrated response, and have compared these results with a conventional, end point glucocorticoid bioassay. We studied natural glucocorticoids (corticosterone and cortisol), synthetic glucocorticoids (dexamethasone) and glucocorticoid precursors with weak, or absent bioactivity. We found a close correlation between half maximal effective concentration (EC50) for maximal response, and for integrated response, but with consistently higher EC50 for the latter. There was no relation between the concentration of ligand and the time to maximal response. A comparison between conventional end point assays and real-time measurement showed similar effects for dexamethasone and hydrocortisone, with a less effective inhibition of IL-6 seen with corticosterone. We profiled the activity of precursor steroids, and found pregnenolone, progesterone, 21-hydroxyprogesterone and 17-hydroxyprogesterone all to be ineffective in the real-time assay, but in contrast, progesterone and 21-hydroxyprogesterone showed an IL-6 inhibitory activity in the end point assay. Taken together, our data show how ligand concentration can alter the amplitude of glucocorticoid response, and also that a comparison between real-time and end point assays reveals an unexpected diversity of the function of glucocorticoid precursor steroids, with implications for human disorders associated with their overproduction

A far-infrared molecular and atomic line survey of the Orion KL region

We have carried out a high spectral resolution line survey towards the Orion Kleinmann-Low (KL) cluster from 44-188 um. The observations were taken with the Long Wavelength Spectrometer (LWS) in Fabry-Perot mode, on board the Infrared Space Observatory (ISO). A total of 152 lines are clearly detected and a further 34 features are present as possible detections. The spectrum is dominated by the molecular species H2O, OH and CO, along with [OI] and [CII] lines from PDR or shocked gas and [OIII], [NIII] lines from the foreground M42 HII region. Several isotopic species, as well as NH3, are also detected. HDO and H3O+ are tentatively detected for the first time in the far-infrared range towards Orion-KL. A basic analysis of the line observations is carried out, by comparing with previous measurements and published models and deriving rotational temperatures and column densities in the case of the molecular species. The complexity of the region requires more sophisticated models for the interpretation of all the line observations.Comment: Accepted by MNRAS 2006 April 2

Living arrangements and place of death of older people with cancer in England and Wales: a record linkage study

The main objectives of the study were to (1) see whether the household circumstances of people aged 50 years and over with cancer, and trends in these, differ from those of the rest of the population and (2) whether living arrangements and presence and health status of a primary coresident are associated with place of death among older people dying of cancer and those dying from other causes. The design included prospective record linkage study of people aged 50 years and over included in a 1% sample of the population of England and Wales (the Office for National Statistics Longitudinal Study). The main outcome measures comprised family and household type, and death at home. The household circumstances of older people with cancer were very similar to those of the rest of the population of the same age and both showed a large increase in living alone, and decrease in living with relatives, between 1981 and 1991. The primary coresident of cancer sufferers who did not live alone was in most cases a spouse, with much smaller proportions living with a child, sibling or other person. In all, 30% of spouse, and 23% of other, primary coresidents had a limiting long-term illness. Compared with people who lived alone in 1991, odds of a home death among those dying of cancer between 1991 and 1995 were highest for those who lived with a spouse who had no limiting long-term illness (odds ratio (OR) 2.52, 95% confidence interval (CI) 2.15-2.97) and raised for those living with a spouse with a long-term illness (OR 2.14, CI 1.79-2.56) and those living with someone else who was free of long-term illness (OR 2.13, CI 1.69-2.68). Higher socioeconomic status, both individual and area, was positively associated with increased chance of a home death, while older age reduced the chance of dying at home. The changing living arrangements of older people have important implications for planning and provision of care and treatment for cancer sufferers

Detection of a Satellite of the Trojan Asteroid (3548) Eurybates—A Lucy Mission Target

We describe the discovery of a satellite of the Trojan asteroid (3548) Eurybates in images obtained with the Hubble Space Telescope. The satellite was detected on three separate epochs, two in 2018 September and one in 2020 January. The satellite has a brightness in all three epochs consistent with an effective diameter of d₂ = 1.2 ± 0.4 km. The projected separation from Eurybates was s ~ 1700–2300 km and varied in position, consistent with a large range of possible orbits. Eurybates is a target of the Lucy Discovery mission and the early detection of a satellite provides an opportunity for a significant expansion of the scientific return from this encounter