Coherent THz emission of Bi_2Sr_2CaCu_2O_8 intrinsic Josephson junction stacks in the hot spot regime

We report on THz emission measurements and low temperature scanning laser imaging of Bi_2Sr_2CaCu_2O_8 intrinsic Josephson junction stacks. Coherent emission is observed at large dc input power, where a hot spot and a standing wave, formed in the "cold" part of the stack, coexist. By varying the hot spot size the cavity resonance frequency and the emitted radiation can be tuned. The linewidth of radiation is much smaller than expected from the quality factor of the cavity mode excited. Thus, an additional mechanism of synchronization seems to play a role, possibly arising from nonequilibrium processes at the hot spot edge.Comment: 4.1 pages, 5 figure

Wavelength-dispersive dark-field contrast: micrometre structure resolution in neutron imaging with gratings

Dark field imaging using grating interferometers has been proven to have a high potential for applications in engineering, magnetism, and soft matter and biophysics, as well as in medicine with both neutrons and X rays. The access to spatially resolved small angle scattering information in neutron dark field imaging provides information about structures beyond direct spatial image resolution. The dark field contrast modality is hence a valuable tool for materials science based on neutron imaging. This is underlined by the success of the method, despite its current limitation to qualitative scattering information. Here it is demonstrated how a wavelength dispersive approach allows such drawbacks to be overcome by providing quantitative structure size information and hence can introduce novel possibilities and insights for materials science

On the needle clogging of staked-in-needle pre-filled syringes: Mechanism of liquid entering the needle and solidification process

Staked-in-needle prefilled syringes (SIN-PFS) are widely used for the parenteral administration of drug product solutions. During stability studies, clogging of the injection needle was observed in syringes filled with concentrated antibody solution. A prerequisite for this phenomenon is that liquid has entered the needle. In this study, we characterized the mechanism causing the entry and movement of liquid in the needle using neutron imaging without manipulating the container closure integrity of the syringe. The gas pressure difference between inside and outside of the syringe was identified as the major cause of liquid movement. The influence of external factors, such as temperature fluctuation and physical pressure on the stopper, were tested and were confirmed to have a relevant impact on the processes of liquid entering and moving inside the injection needle. In a second step, the solidification process of the liquid segments inside the needle via solvent evaporation was further investigated, and the process was found to be dependent on storage time, environmental climate and interaction between the drug product solution and the needle surface. The presence of air/liquid segments was identified as a further factor for the stochastic behavior of needle clogging. For the first time, this fundamental mechanism behind the needle clogging issue was investigated in depth and the results will help to reduce the defect rate for clogged SIN-PFS products

Efeito da solarização sobre propriedades físicas, químicas e biológicas de solos

A solarização é um método de desinfestação que consiste na cobertura do solo com um filme de polietileno transparente, durante o período de intensa radiação solar, e atua por meio do aumento da temperatura do solo. Quatro ensaios foram realizados no estado de São Paulo, nos municípios de Mogi das Cruzes, Jarinu, Piracicaba e Itatiba, nos anos de 2000 e 2001, com o objetivo de avaliar os efeitos da solarização nas propriedades físicas, químicas e biológicas dos solos. A solarização reduziu significativamente a resistência à penetração dos solos nos ensaios de Jarinu, Piracicaba e Itatiba. Em Jarinu, oito meses após a retirada do plástico, as diferenças entre os tratamentos permaneceram. Por outro lado, em Mogi das Cruzes, onde o ensaio foi instalado em solo turfoso, a solarização causou aumento na resistência na camada de 2,5 a 5 cm de profundidade. Nos ensaios de Piracicaba e Jarinu, foram feitas avaliações de macro, microporosidade, porosidade total e densidade, não tendo os tratamentos diferido entre si, porém houve uma tendência de redução na densidade dos solos solarizados. A atividade microbiana, avaliada pela hidrólise de diacetato de fluoresceína, foi reduzida pela solarização. A supressividade a Fusarium oxysporum f. sp. phaseoli foi avaliada in vitro, pela colonização de amostras de solo usando um isolado marcado com resistência a benomyl, no ensaio de Mogi das Cruzes. A solarização reduziu a recuperação do patógeno, evidenciando um aumento da supressividade. Nos solos solarizados, houve aumento significativo dos teores de N-NH4+ em todos os experimentos, Mn em três, N-NO3-, Mg2+ e saturação por bases em dois e K+ em um experimento. Ocorreu redução dos teores de Cu, Fe e H + Al em dois experimentos e Zn em um ensaio. Segundo os resultados, a solarização promoveu alterações nas propriedades físicas, químicas e biológicas dos solos, melhorando a estrutura, liberando nutrientes e aumentando a supressividade

Understanding ecosystems of the future will require more than realistic climate change experiments - a response to Korell et al.

Response to the editor. In response to Korell, L., et al. (2020). We need more realistic climate change experiments for understanding ecosystems of the future. Global Change Biology 26(2): 325-327