257 research outputs found
Left ventricular rotational mechanics in Tanzanian children with sickle cell disease.
BACKGROUND: Sickle cell disease (SCD) is a common inherited hemoglobinopathy. Adults with SCD manifest both systolic and diastolic cardiac dysfunction, though the age of onset of dysfunction has not been defined. Left ventricular (LV) rotational mechanics have not been studied in children with SCD. The aim of this study was to investigate whether cardiac rotational mechanics differed between children with SCD and age-matched controls. METHODS: Basal and apical LV short-axis images were acquired prospectively in 213 patients with SCD (mean age, 14.1 ± 2.6 years) and 49 controls (mean age, 13.3 ± 2.8 years) from the Muhimbili Sickle Cohort in Dar es Salaam, Tanzania. The magnitude of basal and apical rotation, net twist angle, torsion, and untwist rate were obtained by two-dimensional speckle-tracking. The timing of events was normalized to aortic valve closure. RESULTS: Mean basal rotation was significantly lower in patients with SCD compared with controls (P = .012), although no difference was observed in apical rotation (P = .37). No statistically significant differences in torsion or net twist angle were detected. Rotation rate at the apex (P = .001) and base (P = .0004) were significantly slower in subjects with SCD compared with controls. Mean peak untwisting rate was also significantly slower in patients with SCD (P = .006). No associations were found between hemoglobin concentration and apical rotation, basal rotation, net twist, and torsion. CONCLUSION: This study demonstrates alterations in LV rotational mechanics in children with SCD, including lower basal rotation, peak differential twist, and untwist rate. These abnormalities denote subclinical changes in LV systolic and diastolic performance in children with SCD. Future work may reveal an association between rotational metrics and long-term patient outcomes
Effective number of neutrinos and baryon asymmetry from BBN and WMAP
We place constraints on the number of relativistic degrees of freedom and on
the baryon asymmetry at the epoch of Big Bang Nucleosynthesis (BBN) and at
recombination, using cosmic background radiation (CBR) data from the Wilkinson
Microwave Anisotropy Probe (WMAP), complemented by the Hubble Space Telescope
(HST) Key Project measurement of the Hubble constant, along with the latest
compilation of deuterium abundances and measurements of the primordial helium
abundance. The agreement between the derived values of these key cosmological
and particle physics parameters at these widely separated (in time or redshift)
epochs is remarkable. From the combination of CBR and BBN data, we find the
2\sigma ranges for the effective number of neutrinos and for the baryon
asymmetry (baryon to photon number ratio \eta) to be 1.7-3.0 and 5.53-6.76
\times 10^{-10}, respectively.Comment: 10 pages, 10 figures, 2 table
A New Approach to Systematic Uncertainties and Self-Consistency in Helium Abundance Determinations
Tests of big bang nucleosynthesis and early universe cosmology require
precision measurements for helium abundance determinations. However, efforts to
determine the primordial helium abundance via observations of metal poor H II
regions have been limited by significant uncertainties. This work builds upon
previous work by providing an updated and extended program in evaluating these
uncertainties. Procedural consistency is achieved by integrating the hydrogen
based reddening correction with the helium based abundance calculation, i.e.,
all physical parameters are solved for simultaneously. We include new atomic
data for helium recombination and collisional emission based upon recent work
by Porter et al. and wavelength dependent corrections to underlying absorption
are investigated. The set of physical parameters has been expanded here to
include the effects of neutral hydrogen collisional emission. Because of a
degeneracy between the solutions for density and temperature, the precision of
the helium abundance determinations is limited. Also, at lower temperatures (T
\lesssim 13,000 K) the neutral hydrogen fraction is poorly constrained
resulting in a larger uncertainty in the helium abundances. Thus the derived
errors on the helium abundances for individual objects are larger than those
typical of previous studies. The updated emissivities and neutral hydrogen
correction generally raise the abundance. From a regression to zero
metallicity, we find Y_p as 0.2561 \pm 0.0108, in broad agreement with the WMAP
result. Tests with synthetic data show a potential for distinct improvement,
via removal of underlying absorption, using higher resolution spectra. A small
bias in the abundance determination can be reduced significantly and the
calculated helium abundance error can be reduced by \sim 25%.Comment: 51 pages, 13 figure
From (p)reheating to nucleosynthesis
This article gives a brief qualitative description of the possible evolution
of the early Universe between the end of an inflationary epoch and the end of
Big Bang nucleosynthesis. After a general introduction, establishing the
minimum requirements cosmologists impose on this cosmic evolutionary phase,
namely, successful baryogenesis, the production of cosmic dark matter, and
successful light-element nucleosynthesis, a more detailed discussion on some
recent developments follows. This latter includes the physics of preheating,
the putative production of (alternative) dark matter, and the current status of
Big Bang nucleosynthesis.Comment: 18 pages, 6 figures, to be published in "Classical and Quantum
Gravity", article based on a talk presented at ``The Early Universe and
Cosmological Observations: a Critical Review'', Cape Town, July 200
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Phytophthora obscura sp nov., a new species of the novel Phytophthora subclade 8d
A new Phytophthora species was detected (i) in the USA, infecting foliage of Kalmia latifolia, (ii) in substrate underneath Pieris, and (iii) in Germany in soil samples underneath Aesculus hippocastanum showing disease symptoms. The new species Phytophthora obscura sp. nov. is formally named based on phylogenetic analysis, host range, Kochs postulates and morphology. Phytophthora obscura is homothallic with paragynous antheridia and semipapillate sporangia. It is genetically closely related to P.similar to syringae and P. austrocedrae and together these three species define a new Phytophthora subclade 8d, with significant support for all genetic loci analysed including seven nuclear genes and the mitochondrial gene coxII. The morphological and ecological characteristics are very similar to P.similar to syringae, and it is likely that P.similar to obscura was not described earlier because it was identified as P.similar to syringae. Artificial inoculations indicated that horse chestnut, kalmia, pieris and rhododendron might be hosts, and Kochs postulates were confirmed for kalmia from which it was isolated. This pathogen was named after its elusive nature since it has to date rarely been detected in the US and Germany.Keywords: Pieris, Rhododendron, Taxonomy, Oomycete, Kalmia latifolia, Aesculus hippocastanumKeywords: Pieris, Rhododendron, Taxonomy, Oomycete, Kalmia latifolia, Aesculus hippocastanu
The HIV care cascade among female sex workers in Zimbabwe: results of a population-based survey from the Sisters Antiretroviral therapy Programme for Prevention of HIV, an Integrated Response (SAPPH-IRe) Trial.
: Female sex workers (FSW) in sub-Saharan Africa have a higher prevalence of HIV than other women of reproductive age. Social, legal, and structural barriers influence their access to care. Little is known about the HIV diagnosis and care cascade in most countries in Southern Africa. We aimed to describe the HIV diagnosis and care cascade among FSW in Zimbabwe. : We conducted cross-sectional respondent driven sampling (RDS) surveys of FSW in 14 sites across Zimbabwe as the baseline for a cluster-randomised controlled trial investigating a combination HIV prevention and care package. We administered a questionnaire, tested women for HIV and measured viral load. We report the mean, minimum, and maximum respondent-driven sampling-2 weighted site values. : The survey included 2722 women, approximately 200 per site. The mean HIV prevalence was 57.5% (42.8-79.2 site minimum and maximum). Of HIV-positive women, 64.0% (51.6-73.7) were aware of their status, 67.7% (53.4-84.1) of these reported taking antiretroviral therapy, and 77.8% (64.4-90.8) of these had a suppressed HIV viral load (<1000 copies/mL). Among all HIV-positive women, 49.5% had a viral load < 1000 copies/mL. : Although most HIV-positive women aware of their status are accessing antiretroviral therapy, 36.0% of HIV-positive women are unaware of their status and 29.3% of all FSW have an unsuppressed HIV viral load. Investigation and investment into models of testing, treatment, and care are necessary to reach UNAIDS targets for HIV elimination.<br/
Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp maritima: from traditional remedies to prospective products
This work explored the biotechnological potential of the medicinal halophyte Artemisia campestris subsp. maritima (dune wormwood) as a source of health promoting commodities. For that purpose, infusions, decoctions and tinctures were prepared from roots and aerial-organs and evaluated for in vitro antioxidant, anti-diabetic and tyrosinase-inhibitory potential, and also for polyphenolic and mineral contents and toxicity. The dune wormwood extracts had high polyphenolic content and several phenolics were identified by ultra-high performance liquid chromatography-photodiode array-mass-spectrometry (UHPLC-PDA-MS). The main compounds were quinic, chlorogenic and caffeic acids, coumarin sulfates and dicaffeoylquinic acids; several of the identified phytoconstituents are here firstly reported in this A. campestris subspecies. Results obtained with this plant's extracts point to nutritional applications as mineral supplementary source, safe for human consumption, as suggested by the moderate to low toxicity of the extracts towards mammalian cell lines. The dune wormwood extracts had in general high antioxidant activity and also the capacity to inhibit a-glucosidase and tyrosinase. In summary, dune wormwood extracts are a significant source of polyphenolic and mineral constituents, antioxidants and a-glucosidase and tyrosinase inhibitors, and thus, relevant for different commercial segments like the pharmaceutical, cosmetic and/or food industries.FCT - Foundation for Science and Technology [CCMAR/Multi/04326/2013]; Portuguese National Budget; FCT [IF/00049/2012, SFRH/BD/94407/2013]; Research Foundation - Flanders (FWO) [12M8315N]info:eu-repo/semantics/publishedVersio
Primordial black holes in braneworld cosmologies: astrophysical constraints
In two recent papers we explored the modifications to primordial black hole
physics when one moves to the simplest braneworld model, Randall--Sundrum type
II. Both the evaporation law and the cosmological evolution of the population
can be modified, and additionally accretion of energy from the background can
be dominant over evaporation at high energies. In this paper we present a
detailed study of how this impacts upon various astrophysical constraints,
analyzing constraints from the present density, from the present high-energy
photon background radiation, from distortion of the microwave background
spectrum, and from processes affecting light element abundances both during and
after nucleosynthesis. Typically, the constraints on the formation rate of
primordial black holes weaken as compared to the standard cosmology if black
hole accretion is unimportant at high energies, but can be strengthened in the
case of efficient accretion.Comment: 17 pages RevTeX4 file with three figures incorporated; final paper in
series astro-ph/0205149 and astro-ph/0208299. Minor changes to match version
accepted by Physical Review
ESMO Clinical Research Observatory (ECRO): improving the efficiency of clinical research through rationalisation of bureaucracy
During the last years, there has been a dramatic increase in the administrative and bureaucratic burden associated with cli
Fantastically reasonable: ambivalence in the representation of science and technology in super-hero comics
A long-standing contrast in academic discussions of science concerns its perceived disenchanting or enchanting public impact. In one image, science displaces magical belief in unknowable entities with belief in knowable forces and processes and reduces all things to a single technical measure. In the other, science is itself magically transcendent, expressed in technological adulation and an image of scientists as wizards or priests. This paper shows that these contrasting images are also found in representations of science in super-hero comics, which, given their lowly status in Anglo-American culture, would seem an unlikely place to find such commonality with academic discourse. It is argued that this is evidence that the contrast constitutes an ambivalence arising from the dilemmas that science poses; they are shared rhetorics arising from and reflexively feeding a set of broad cultural concerns. This is explored through consideration of representations of science at a number of levels in the comics, with particular focus on the science-magic constellation, and enchanted and disenchanted imagery in representations of technology and scientists. It is concluded that super-hero comics are one cultural arena where the public meaning of science is actively worked out, an activity that unites “expert” and “non-expert” alike
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