Development of New Venture Support Networks and the Role of "Promoters"

New Venture Support Networks (NVSN) are a political instrument for the purpose of contributing to regional economic development by fostering more and qualitatively better start-ups. NVSN bundle together different available sources of information and consultation for potential entrepreneurs, including e.g. authorities, universities, financial institutions, trade associations and private consultants. Achieving effective cooperation between such a wide range of institutions is not a simple task. The initial situation is often characterised by conflicts between the varying individual interests of the participants and the politically defined goal of fostering more and better start-ups. Moreover, since the network has been established by a political initiative for a pre-determined funding period, the actor relations within it are “artificial” (as opposed to naturally developed). Thus, the actors lack common experiences, social bonds, values and other common motivators contributing to trust-based cooperative relationships. Such relationships are a crucial factor in turning the “artificial” network into a “real” one, which continues to exist also after the political funding period is over. Our hypothesis is that certain key actors are a critical success factor in developing NVSN into “real” networks. Following the “promoter model” – an expansion of champion models that has established itself in the German innovation management literature – we suggest that there are administrative, organisational and know-how related barriers that are detrimental to the development of NVSN. The overcoming of these barriers requires a combination of different organisational resources, which the promoter model discusses in terms of three different ideal types: promoter by power, promoter by know-how, and relationship promoter. One person can act in one or more of these roles simultaneously and the roles can appear in different combinations, known as promoter structures. The specific research objectives of the proposed paper are to identify a) the types of barriers faced in the different developmental stages of NVSN and b) the roles the key actors play and the resources they use in coping with them. Our sample consists of key actors in five regional NVSN in Germany, which were established in 1998 as part of the governmental initiative “EXIST – Entrepreneurs from Universities”. The author team is also involved in one of these networks. Using a grounded theory based qualitative approach, we intend to map the development process of these NVSN with respect to the above research objectives. The contribution of the study is two-fold: 1) It presents the first application of the promoter model in the context of NVSN and produces tentative results that can be used as a basis for further research. 2) It offers practical implications to NVSN by analysing how their effectiveness and continuity could be improved by an effective use of promoter structures.

Bioanalytical applications of real-time ATP imaging via bioluminescence

The research discussed within involves the development of novel applications of real-time imaging of adenosine 5\u27-triphosphate (ATP). ATP was detected via bioluminescence from the firefly luciferase-catalyzed reaction of ATP and luciferin. The use of a microscope and an imaging detector allowed for spatially resolved quantitation of ATP release. Employing this method, applications in both biological and chemical systems were developed.;First, the mechanism by which the compound 48/80 induces release of ATP from human umbilical vein endothelial cells (HUVECs) was investigated. Numerous enzyme activators and inhibitors were utilized to probe the second messenger systems involved in release. Compound 48/80 activated a Gq-type protein to initiate ATP release from HUVECs. Ca2+ imaging along with ATP imaging revealed that activation of phospholipase C and induction of intracellular Ca2+ signaling were necessary for release of ATP. This novel release mechanism was compared to the existing theories of extracellular release of ATP.;Bioluminescence imaging was also employed to examine the role of ATP in the field of neuroscience. The central nervous system (CNS) was dissected from the freshwater snail Lymnaea stagnalis. Electrophysiological experiments demonstrated that the neurons of the Lymnaea were not damaged by any of the components of the imaging solution. ATP was continuously released by the ganglia of the CNS for over eight hours and varied from ganglion to ganglion and within individual ganglia. Addition of the neurotransmitters K+ and serotonin increased release of ATP in certain regions of the Lymnaea CNS.;Finally, the ATP imaging technique was investigated for the study of drug release systems. MCM-41-type mesoporous nanospheres were loaded with ATP and end-capped with US nanocrystals and PAMAM dendrimers. Aggregates of nanospheres were bathed in imaging solution, and ATP bioluminescence was monitored to investigate the release kinetics of the nanosphere drug delivery systems. Addition of disulfide bond-cleaving molecules induced uncapping of the nanospheres and subsequently, the release of ATP. Increasing the concentration of the uncapping molecule decreased the temporal maximum and increased the magnitude of release of encapsulated ATP from the nanospheres

Development of New Venture Support Networks and the Role of "Promoters"

New Venture Support Networks (NVSN) are a political instrument for the purpose of contributing to regional economic development by fostering more and qualitatively better start-ups. NVSN bundle together different available sources of information and consultation for potential entrepreneurs, including e.g. authorities, universities, financial institutions, trade associations and private consultants. Achieving effective cooperation between such a wide range of institutions is not a simple task. The initial situation is often characterised by conflicts between the varying individual interests of the participants and the politically defined goal of fostering more and better start-ups. Moreover, since the network has been established by a political initiative for a pre-determined funding period, the actor relations within it are “artificial” (as opposed to naturally developed). Thus, the actors lack common experiences, social bonds, values and other common motivators contributing to trust-based cooperative relationships. Such relationships are a crucial factor in turning the “artificial” network into a “real” one, which continues to exist also after the political funding period is over. Our hypothesis is that certain key actors are a critical success factor in developing NVSN into “real” networks. Following the “promoter model” – an expansion of champion models that has established itself in the German innovation management literature – we suggest that there are administrative, organisational and know-how related barriers that are detrimental to the development of NVSN. The overcoming of these barriers requires a combination of different organisational resources, which the promoter model discusses in terms of three different ideal types: promoter by power, promoter by know-how, and relationship promoter. One person can act in one or more of these roles simultaneously and the roles can appear in different combinations, known as promoter structures. The specific research objectives of the proposed paper are to identify a) the types of barriers faced in the different developmental stages of NVSN and b) the roles the key actors play and the resources they use in coping with them. Our sample consists of key actors in five regional NVSN in Germany, which were established in 1998 as part of the governmental initiative “EXIST – Entrepreneurs from Universities”. The author team is also involved in one of these networks. Using a grounded theory based qualitative approach, we intend to map the development process of these NVSN with respect to the above research objectives. The contribution of the study is two-fold: 1) It presents the first application of the promoter model in the context of NVSN and produces tentative results that can be used as a basis for further research. 2) It offers practical implications to NVSN by analysing how their effectiveness and continuity could be improved by an effective use of promoter structures

Maine Distributed Solar Valuation Study

During its 2014 session, the Maine Legislature enacted an Act to Support Solar Energy Development in Maine. P.L Chapter 562 (April 24, 2014) (codified at 35‐A M.R.S. §§ 3471‐3473) (“Act”). Section 1 of the Act contains the Legislative finding that it is in the public interest is to develop renewable energy resources, including solar energy, in a manner that protects and improves the health and well‐being of the citizens and natural environment of the State while also providing economic benefits to communities, ratepayers and the overall economy of the State. Section 2 of the Act requires the Public Utilities Commission (Commission) to determine the value of distributed solar energy generation in the State, evaluate implementation options, and to deliver a report to the Legislature. To support this work, the Commission engaged a project team comprising Clean Power Research (Napa, California), Sustainable Energy Advantage (Framingham, Massachusetts), Pace Energy and Climate Center at the Pace Law School (White Plains, New York), and Dr. Richard Perez (Albany, New York). Under the project, the team developed the methodology under a Commission‐run stakeholder review process, conducted a valuation on distributed solar for three utility territories, and developed a summary of implementation options for increasing deployment of distributed solar generation in the State. The report includes three volumes which accompany this Executive Summary: Volume I Methodology; Volume II Valuation Results; Volume III Implementation Options

Zur Iris-Bewegung

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In Flight Evaluation of Active Inceptor Force-Feel Characteristics and Handling Qualities

The effect of inceptor feel-system characteristics on piloted handling qualities has been a research topic of interest for many years. Most of the research efforts have focused on advanced fly-by-wire fixed-wing aircraft with only a few studies investigating the effects on rotorcraft. Consequently, only limited guidance is available on how cyclic force-feel characteristics should be set to obtain optimal handling qualities for rotorcraft. To study this effect, the U.S. Army Aeroflightdynamics Directorate working with the DLR Institute of Flight Systems in Germany under Task X of the U.S. German Memorandum of Understanding have been conducting flight test evaluations. In the U.S., five experimental test pilots have completed evaluations of two Mission Task Elements (MTEs) from ADS-33E-PRF and two command/response types for a matrix of center-stick cyclic force-feel characteristics at Moffett Field. In Germany, three experimental test Pilots have conducted initial evaluations of the two MTEs with two command/response types for a parallel matrix of side-stick cyclic force-feel characteristics at WTD-61 in Manching. The resulting data set is used to correlate the effect of changes in natural frequency and damping ratio of the cyclic inceptor on the piloted handling qualities. Existing criteria in ADS-33E and a proposed Handling Qualities Sensitivity Function that includes the effects of the cyclic force-feel characteristics are also evaluated against the data set and discussed

Satori 2023

The Satori is a student literary publication that expresses the artistic spirit of the students of Winona State University. Student poetry, prose, and graphic art are published in the Satori every spring since 1970. The Satori 2023 editors are Gabriel Hathaway, Van Herman, Madeline Schonitzer, Brianna Strohbehn, Page Sutton, Willow Swinbank, and Emily Venné. The Satori 2023 faculty advisor is Dr. Jim Armstrong, Professor of English.https://openriver.winona.edu/satori/1010/thumbnail.jp

Survival after resection of malignant peripheral nerve sheath tumors:Introducing and validating a novel type-specific prognostic model

Background: This study aimed to assess the performance of currently available risk calculators in a cohort of patients with malignant peripheral nerve sheath tumors (MPNST) and to create an MPNST-specific prognostic model including type-specific predictors for overall survival (OS). Methods: This is a retrospective multicenter cohort study of patients with MPNST from 11 secondary or tertiary centers in The Netherlands, Italy and the United States of America. All patients diagnosed with primary MPNST who underwent macroscopically complete surgical resection from 2000 to 2019 were included in this study. A multivariable Cox proportional hazard model for OS was estimated with prespecified predictors (age, grade, size, NF-1 status, triton status, depth, tumor location, and surgical margin). Model performance was assessed for the Sarculator and PERSARC calculators by examining discrimination (C-index) and calibration (calibration plots and observed-expected statistic; O/E-statistic). Internal-external cross-validation by different regions was performed to evaluate the generalizability of the model. Results: A total of 507 patients with primary MPNSTs were included from 11 centers in 7 regions. During follow-up (median 8.7 years), 211 patients died. The C-index was 0.60 (95% CI 0.53-0.67) for both Sarculator and PERSARC. The MPNST-specific model had a pooled C-index of 0.69 (95%CI 0.65-0.73) at validation, with adequate discrimination and calibration across regions. Conclusions: The MPNST-specific MONACO model can be used to predict 3-, 5-, and 10-year OS in patients with primary MPNST who underwent macroscopically complete surgical resection. Further validation may refine the model to inform patients and physicians on prognosis and support them in shared decision-making.</p