LpL^p-approximation of the integrated density of states for Schr\"odinger operators with finite local complexity

We study spectral properties of Schr\"odinger operators on \RR^d. The electromagnetic potential is assumed to be determined locally by a colouring of the lattice points in \ZZ^d, with the property that frequencies of finite patterns are well defined. We prove that the integrated density of states (spectral distribution function) is approximated by its finite volume analogues, i.e.the normalised eigenvalue counting functions. The convergence holds in the space $L^p(I)$ where $I$ is any finite energy interval and $1\leq p< \infty$ is arbitrary.Comment: 15 pages; v2 has minor fixe

Energy self-sufficient systems for monitoring sewer networks

Underground infrastructure networks form the backbone of vital supply and disposal systems. However, they are under-monitored in comparison to their value. This is due, in large part, to the lack of energy supply for monitoring and data transmission. In this paper, we investigate a novel, energy harvesting system used to power underground sewer infrastructure monitoring networks. The system collects the required energy from ambient sources, such as temperature differences or residual light in sewer networks. A prototype was developed that could use either a thermoelectric generator (TEG) or a solar cell to capture the energy needed to acquire and transmit ultrasonic water level data via LoRaWAN. Real-world field trials were satisfactory and showed the potential power output, as well as, possibilities to improve the system. Using an extrapolation model, we proved that the developed solution could work reliably throughout the year.Comment: To be published in proceedings of the conference "21. ITG/GMA- Fachtagung Sensoren und Messsysteme 2022", 10.-11. Mai 2022, N\"urnberger CongressCenter, Nuremberg, Germany, or IEEE explor

Contrails and their impact on shortwave radiation and photovoltaic power production – a regional model study

A high-resolution regional-scale numerical model was extended by a parameterization that allows for both the generation and the life cycle of contrails and contrail cirrus to be calculated. The life cycle of contrails and contrail cirrus is described by a two-moment cloud microphysical scheme that was extended by a separate contrail ice class for a better representation of the high concentration of small ice crystals that occur in contrails. The basic input data set contains the spatially and temporally highly resolved flight trajectories over Central Europe derived from real-time data. The parameterization provides aircraft-dependent source terms for contrail ice mass and number. A case study was performed to investigate the influence of contrails and contrail cirrus on the shortwave radiative fluxes at the earth’s surface. Accounting for contrails produced by aircraft enabled the model to simulate high clouds that were otherwise missing on this day. The effect of these extra clouds was to reduce the incoming shortwave radiation at the surface as well as the production of photovoltaic power by up to 10 %

Expert chess memory: Revisiting the chunking hypothesis

After reviewing the relevant theory on chess expertise, this paper re-examines experimentally the finding of Chase and Simon (1973a) that the differences in ability of chess players at different skill levels to copy and to recall positions are attributable to the experts' storage of thousands of chunks (patterned clusters of pieces) in long-term memory. Despite important differences in the experimental apparatus, the data of the present experiments regarding latencies and chess relations between successively placed pieces are highly correlated with those of Chase and Simon. We conclude that the 2-second inter-chunk interval used to define chunk boundaries is robust, and that chunks have psychological reality. We discuss the possible reasons why Masters in our new study used substantially larger chunks than the Master of the 1973 study, and extend the chunking theory to take account of the evidence for large retrieval structures (templates) in long-term memory

Does genre make a difference? Classical orchestra/popular band musicians’ motivation, self-efficacy, and practice experiences’ effects on deliberate practice

This study investigates the motivational conditions, self-efficacy beliefs, and practice of classical (symphonic, wind) orchestra/popular (rock, pop) band musicians. It thus complements previous research which has shed light on individual aspects of music learning. In both individual and collective work, high quality practice performed in a sufficient amount of time was shown to be very effortful. A mixed-method approach combined a questionnaire and an additional prototypical case interview for each genre with professional musicians. The results show that classical musicians were younger than popular musicians when they started to learn their first and main music instrument and entered their first orchestra or band. While it was confirmed that individual experience was crucial for the time invested in and the quality of deliberate practice, collective practice experiences were also indicated to be a determinant. Furthermore, individual and collective practice were shown to be interrelated. Professional level was suggested to be a more discriminating factor with regard to the variables studied than genre, as professional musicians from both genres deploy deliberate practice strategies in an individual and in a collective context. Improvisation and jamming, however, only appeared in the popular collective and classical individual practice context

Light-cone distribution amplitudes of octet baryons from lattice QCD

We present lattice QCD results for the wave function normalization constants and the first moments of the distribution amplitudes for the lowest-lying baryon octet. The analysis is based on a large number of $N_f=2+1$ ensembles comprising multiple trajectories in the quark mass plane including physical pion (and kaon) masses, large volumes, and, most importantly, five different lattice spacings down to $a=0.039\,\mathrm{fm}$. This allows us to perform a controlled extrapolation to the continuum and infinite volume limits by a simultaneous fit to all available data. We demonstrate that the formerly observed violation of flavor symmetry breaking constraints can, indeed, be attributed to discretization effects that vanish in the continuum limit

Localization of cavities in cast components via impulse excitation and a finite element analysis

In this work, the acoustic resonance testing method has been extended by a finite element analysis of the examined component to localize cavities within die casting parts. This novel method aims at a fast and efficient quality inspection which allows hidden cavities in cast components to be detected, which is only possible with X-ray technology at the moment. The promising results show that this method enables the localization of shrinkage cavities. Furthermore, the influence of product scatter has been analyzed regarding the accuracy of the calculated position of artificial defects

Ganetespib selectively sensitizes cancer cells for proximal and distal spread-out Bragg peak proton irradiation

Objective: Hypersensitivity towards proton versus photon irradiation was demonstrated in homologous recombination repair (HRR)-deficient cell lines. Hence, combined treatment concepts targeting HRR provide a rational for potential pharmaceutical exploitation. The HSP90 inhibitor ganetespib (STA-9090) downregulates a multitude of HRR-associated proteins and sensitizes for certain chemotherapeutics. Thus, the radiosensitizing effect of HSP90-inhibiting ganetespib was investigated for reference photon irradiation and proton irradiation at a proximal and distal position in a spread-out Bragg peak (SOBP). Methods: A549 and FaDu cells were treated with low-dose (2 nM resp. 1 nM) ganetespib and irradiated with 200 kV photons. Proton irradiation was performed at a proximal and a distal position within a SOBP, with corresponding dose-averaged linear-energy transfer (LETD) values of 2.1 and 4.5 keV/µm, respectively. Cellular survival data was fitted to the linear-quadratic model to calculate relative biological effectiveness (RBE) and the dose-modifying factor (DMF). Additionally, A549 cells were treated with increasing doses of ganetespib and investigated by flow cytometry, immunoblotting, and immunofluorescence microscopy to investigate cell cycle distribution, Rad51 protein levels, and γH2AX foci, respectively. Results: Low-dosed ganetespib significantly sensitized both cancer cell lines exclusively for proton irradiation at both investigated LETD, resulting in increased RBE values of 10-40%. In comparison to photon irradiation, the fraction of cells in S/G2/M phase was elevated in response to proton irradiation with 10 nM ganetespib consistently reducing this population. No changes in cell cycle distribution were detected in unirradiated cells by ganetespib alone. Protein levels of Rad51 are downregulated in irradiated A549 cells by 10 nM and also 2 nM ganetespib within 24 h. Immunofluorescence staining demonstrated similar induction and removal of γH2AX foci, irrespective of irradiation type or ganetespib administration. Conclusion: Our findings illustrate a proton-specific sensitizing effect of low-dosed ganetespib in both employed cell lines and at both investigated SOBP positions. We provide additional experimental data on cellular response and a rational for future combinatorial approaches with proton radiotherapy. Keywords: Ganetespib; HSP90; Linear energy transfer; Proton radiotherapy; Rad5

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription

Birt–Hogg–Dubé (BHD) syndrome is an inherited cancer susceptibility disease characterized by skin and kidney tumors, as well as cystic lung disease, which results from loss-of-function mutations in the BHD gene. BHD is also inactivated in a significant fraction of patients with sporadic renal cancers and idiopathic cystic lung disease, and little is known about its mode of action. To investigate the molecular and cellular basis of BHD tumor suppressor activity, we generated mutant Bhd mice and embryonic stem cell lines. BHD-deficient cells exhibited defects in cell-intrinsic apoptosis that correlated with reduced expression of the BH3-only protein Bim, which was similarly observed in all human and murine BHD-related tumors examined. We further demonstrate that Bim deficiency in Bhd−/− cells is not a consequence of elevated mTOR or ERK activity, but results instead from reduced Bim transcription associated with a general loss of TGFβ-mediated transcription and chromatin modifications. In aggregate, this work identifies a specific tumor suppressive mechanism for BHD in regulating TGFβ-dependent transcription and apoptosis, which has implications for the development of targeted therapies