Parley P. Pratt: The Apostle Paul of Mormonism

After Joseph Smith and Brigham Young, Parley P. Pratt was the most influential figure in early Mormon history and culture. Missionary, pamphleteer, theologian, historian, and martyr, Pratt was perennially stalked by controversy--regarded, he said, almost as an Angel by thousands and counted an Imposter by tens of thousands. Tracing the life of this colorful figure from his hardscrabble origins in upstate New York to his murder in 1857, Terryl Givens and Matthew Grow explore the crucial role Pratt played in the formation and expansion of early Mormonism. One of countless ministers inspired by the antebellum revival movement known as the Second Great Awakening, Pratt joined the Mormons in 1830 at the age of twenty three and five years later became a member of the newly formed Quorum of the Twelve Apostles, which vaulted him to the forefront of church leadership for the rest of his life. Pratt\u27s missionary work--reaching from Canada to England, from Chile to California--won hundreds of followers, but even more important were his voluminous writings. Through books, newspaper articles, pamphlets, poetry, fiction, and autobiography, Pratt spread the Latter-day Saint message, battled the many who reviled it, and delineated its theology in ways that still shape Mormon thought. Drawing on letters, journals, and other rich archival sources, Givens and Grow examine not only Pratt\u27s writings but also his complex personal life. A polygamist who married a dozen times and fathered thirty children, Pratt took immense joy in his family circle even as his devotion to Mormonism led to long absences that put heavy strains on those he loved. It was during one such absence, a mission trip to the East, that the estranged husband of his twelfth wife shot and killed him--a shocking conclusion to a life that never lacked in drama.https://scholarship.richmond.edu/bookshelf/1073/thumbnail.jp

Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Society of Toxicology for personal use, not for redistribution. The definitive version was published in Toxicological Sciences 85 (2005): 683-693, doi:10.1093/toxsci/kfi116.2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant that causes altered heart morphology, circulatory impairment, edema, hemorrhage, and early life stage mortality in fish. TCDD toxicity is largely dependent upon the aryl hydrocarbon receptor, but understanding of the molecular mechanism of cardiovascular embryotoxicity remains incomplete. In order to identify genes potentially involved in cardiovascular impacts, we constructed custom cDNA microarrays consisting of 4,896 zebrafish adult heart cDNA clones and over 200 genes with known developmental, toxicological, and housekeeping roles. Gene expression profiles were obtained for 3-day old zebrafish following early embryonic exposure to either 0.5 or 5.0 nM TCDD. 516 clones were significantly differentially expressed (p-value < 0.005) under at least one treatment condition; 123 high-priority clones were selected for further investigation. CYP1A, CYP1B1, and other members of the AHR gene battery, were strongly and dose-dependently induced by TCDD. Importantly, altered expression of cardiac sarcomere components, including cardiac troponin T2 and multiple myosin isoforms, was consistent with the hypothesis that TCDD causes dilated cardiomyopathy. Observed increases in expression levels of mitochondrial energy transfer genes also may be related to cardiomyopathy. Other TCDD-responsive genes included fatty acid and steroid metabolism enzymes, ribosomal and signal transduction proteins, and 18 ESTs with no known protein homologs. As the first broadscale study of TCDD-modulated gene expression in a non-mammalian system, this work provides an important perspective on mechanisms of TCDD toxicity.This work was supported by funding from the National Institutes of Health

Addressing Prediabetes in Childhood Obesity Treatment Programs: Support from Research and Current Practice

Background: Type 2 diabetes mellitus (T2DM) and prediabetes have increased in prevalence among overweight and obese children, with significant implications for long-term health. There is little published evidence on the best approaches to care of prediabetes among overweight youth or the current practices used across pediatric weight management programs. Methods: This article reviews the literature and summarizes current practices for screening, diagnosis, and treatment of prediabetes at childhood obesity treatment centers. Findings regarding current practice were based on responses to an online survey from 28 pediatric weight management programs at 25 children's hospitals in 2012. Based on the literature reviewed, and empiric data, consensus support statements on prediabetes care and T2DM prevention were developed among representatives of these 25 children's hospitals' obesity clinics. Results: The evidence reviewed demonstrates that current T2DM and prediabetes diagnostic parameters are derived from adult-based studies with little understanding of clinical outcomes among youth. Very limited evidence exists on preventing progression of prediabetes. Some evidence suggests that a significant proportion of obese youth with prediabetes will revert to normoglycemia without pharmacological management. Evidence supports lifestyle modification for children with prediabetes, but further study of specific lifestyle changes and pharmacological treatments is needed. Conclusion: Evidence to guide management of prediabetes in children is limited. Current practice patterns of pediatric weight management programs show areas of variability in practice, reflecting the limited evidence base. More research is needed to guide clinical care for overweight youth with prediabetes.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140337/1/chi.2013.0158.pd

"Saints Observed": Outside Observations of Mormon Life

A Review Essay on Saints Observed: Studies of Mormon Village Life, 1850-2005 and Fourt Classic Mormon Village Studie

Inferring crustal structure in the Aleutian island arc from a sparse wide-angle seismic data set

Compressional seismic travel times from a relatively sparse wide-angle data set hold key information on the structure of a 800 km long section of the central Aleutian arc. Since the source and receiver locations form a swath along the arc crest that is similar to50 km wide, we trace rays in 3-D for a collection of 8336 seismic refraction and reflection arrivals. We investigate variations in seismic velocity structure parallel to the Aleutian arc, assuming that our result represents average crustal structure across the arc. We explore seismic velocity models that consist of three crustal layers that exhibit smooth variations in structure in the 2-D vertical plane. We consider the influence of additional constraints and model parameterization in our search for a plausible model for Aleutian arc crust. A tomographic inversion with static corrections for island stations reduces the data variance of a 1-D starting model by 91%. Our best model has seismic velocities of 6.0-6.5 km/s in the upper crust, 6.5-7.3 km/s in the middle crust, and 7.3-7.7 km/s in the lower crust and a total crustal thickness of 35-37+/-1 km. A resolution analysis shows that features having a horizontal scale less than 20 km cannot be imaged, but at horizontal length scales of similar to50 km most model features are well resolved. The study indicates that the Aleutian island arc crust is thick compared to other island arcs and strongly stratified and that only the upper 60% of the arc crust has seismic velocities that are comparable to average seismic velocities in continental crust