10 research outputs found

    Les exemples de la Russie et de la Rome Antique

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    Nous nous proposons d'étudier la chronologie des expansions de l'Empire Russe et de la Rome Antique. Ces expansions se sont déroulées durant plusieurs siècles dans des contrées fort différentes, à des époques également différentes, avant de s'achever par des crises majeures qui ont débouchées dans le premier cas sur la révolution bolchevique de 1917 et dans l'autre par son implosion laissant à Byzance la proéminence parmi les pays méditerranéens. L'histoire de ces conquêtes et l'étude des deux chronologies devraient permettre de caractériser ces extensions territoriales et, en particulier, de montrer que ces évolutions ont un comportement log-périodique déjà mis en évidence dans un grand nombre d'exemples ne concernant pas uniquement les sciences sociales et humaines.Territories of the Russian Empire and of the Roman Empire expanded over a period of several centuries, but independently of the time and of the geographic areas. Their evolution took the form of series of jumps followed by a pause indicating a deceleration mode from a critical time. Such a system could be described by a log-periodic law. This type of behaviour can be observed in the chronology of various phenomena (species evolution of echinoderms, dinosaurs, rodents, equids, primates and hominids; human ontogeny, financial crashes and earthquakes…)

    Structures financières des groupes industriels et bancaires

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    Grou Pierre. Structures financières des groupes industriels et bancaires. In: Tiers-Monde, tome 30, n°119, 1989. L'Inde : libéralisation et enjeux sociaux, sous la direction de Bernadette Madeuf et Philippe Cadène. pp. 577-593

    Profils financiers des groupes industriels multinationaux : réexamen d'un concept

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    Grou Pierre. Profils financiers des groupes industriels multinationaux : réexamen d'un concept. In: Revue d'économie industrielle, vol. 47, 1er trimestre 1989. Les groupes industriels et financiers. pp. 66-79

    Management of bone metastasis with zoledronic acid: A systematic review and Bayesian network meta-analysis

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    Background: While considered the mainstay of treatment for specific bone metastases, ZA is used predominantly to treat osteolytic lesions. The purpose of this network meta-analysis is to compare ZA to other treatment options in its ability to improve specific clinical outcomes in patients with bone metastases secondary to any primary tumor. Methods: PubMed, Embase and Web of Science were systematically searched from inception to May 5th, 2022. Keywords used were solid tumor, lung neoplasm, kidney neoplasm, breast neoplasm, prostate neoplasm, ZA and bone metastasis. Every randomized controlled trial and non-randomized quasi-experimental study of systemic ZA administration for patients with bone metastases and any comparator were included. A Bayesian network meta-analysis was done on the primary outcomes including number of SREs, time to developing a first on-study SRE, overall survival, and disease progression-free survival. Secondary outcome was pain at 3, 6 and 12 months after treatment. Results: Our search yielded 3861 titles with 27 meeting inclusion criteria. For the number of SRE, ZA in combination with chemotherapy or hormone therapy was statistically superior to placebo (OR 0.079; 95 % CrI: 0.022–0.27). For the time to the first on study SRE, the relative effectiveness of ZA 4 mg was statistically superior to placebo (HR 0.58; 95 % CrI:0.48–0.77). At 3 and 6 months, ZA 4 mg was significantly superior to placebo for reducing pain with a SMD of −0.85 (95 % CrI:-1.6, −0.0025) and −2.6 (95 % CrI:-4.7, −0.52) respectively. Conclusions: This systematic review shows the benefits of ZA in decreasing the incidence of SREs, increasing the time to the first on-study SRE, and reducing the pain level at 3 and 6 months
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