3,442 research outputs found
First Long-Term Application of Squeezed States of Light in a Gravitational-Wave Observatory
We report on the first long-term application of squeezed vacuum states of
light to improve the shot-noise-limited sensitivity of a gravitational-wave
observatory. In particular, squeezed vacuum was applied to the German/British
detector GEO600 during a period of three months from June to August 2011, when
GEO600 was performing an observational run together with the French/Italian
Virgo detector. In a second period squeezing application continued for about 11
months from November 2011 to October 2012. During this time, squeezed vacuum
was applied for 90.2% (205.2 days total) of the time that science-quality data
was acquired with GEO600. Sensitivity increase from squeezed vacuum application
was observed broad-band above 400Hz. The time average of gain in sensitivity
was 26% (2.0dB), determined in the frequency band from 3.7kHz to 4.0kHz. This
corresponds to a factor of two increase in observed volume of the universe, for
sources in the kHz region (e.g. supernovae, magnetars). We introduce three new
techniques to enable stable long-term application of squeezed light, and show
that the glitch-rate of the detector did not increase from squeezing
application. Squeezed vacuum states of light have arrived as a permanent
application, capable of increasing the astrophysical reach of
gravitational-wave detectors.Comment: 4 pages, 4 figure
Would You Choose to be Happy? Tradeoffs Between Happiness and the Other Dimensions of Life in a Large Population Survey
A large literature documents the correlates and causes of subjective well-being, or happiness. But few studies have investigated whether people choose happiness. Is happiness all that people want from life, or are they willing to sacrifice it for other attributes, such as income and health? Tackling this question has largely been the preserve of philosophers. In this article, we find out just how much happiness matters to ordinary citizens. Our sample consists of nearly 13,000 members of the UK and US general populations. We ask them to choose between, and make judgments over, lives that are high (or low) in different types of happiness and low (or high) in income, physical health, family, career success, or education. We find that people by and large choose the life that is highest in happiness but health is by far the most important other concern, with considerable numbers of people choosing to be healthy rather than happy. We discuss some possible reasons for this preference
Optimal time-domain combination of the two calibrated output quadratures of GEO 600
GEO 600 is an interferometric gravitational wave detector with a 600 m arm-length and which uses a dual-recycled optical configuration to give enhanced sensitivity over certain frequencies in the detection band. Due to the dual-recycling, GEO 600 has two main output signals, both of which potentially contain gravitational wave signals. These two outputs are calibrated to strain using a time-domain method. In order to simplify the analysis of the GEO 600 data set, it is desirable to combine these two calibrated outputs to form a single strain signal that has optimal signal-to-noise ratio across the detection band. This paper describes a time-domain method for doing this combination. The method presented is similar to one developed for optimally combining the outputs of two colocated gravitational wave detectors. In the scheme presented in this paper, some simplifications are made to allow its implementation using time-domain methods
The upgrade of GEO600
The German / British gravitational wave detector GEO 600 is in the process of
being upgraded. The upgrading process of GEO 600, called GEO-HF, will
concentrate on the improvement of the sensitivity for high frequency signals
and the demonstration of advanced technologies. In the years 2009 to 2011 the
detector will undergo a series of upgrade steps, which are described in this
paper.Comment: 9 pages, Amaldi 8 conference contributio
ABAEnrichment: An R package to test for gene set expression enrichment in the adult and developing human brain
Summary: We present ABAEnrichment, an R package that tests for expression enrichment in specific brain regions at different developmental stages using expression information gathered from multiple regions of the adult and developing human brain, together with ontologically organized structural information about the brain, both provided by the Allen Brain Atlas. We validate ABAEnrichment by successfully recovering the origin of gene sets identified in specific brain cell-types and developmental stages. Availability and Implementation: ABAEnrichment was implemented as an R package and is available under GPL (â„â2) from the Bioconductor website (http://bioconductor.org/packages/3.3/bioc/html/ABAEnrichment.html). Contacts: [email protected], [email protected] or [email protected] Supplementary information: Supplementary data are available at Bioinformatics online
Performance of a 1200m long suspended Fabry-Perot cavity
Using one arm of the Michelson interferometer and the power recycling mirror
of the interferometric gravitational wave detector GEO600, we created a
Fabry-Perot cavity with a length of 1200 m. The main purpose of this experiment
was to gather first experience with the main optics, its suspensions and the
corresponding control systems. The residual displacement of a main mirror is
about 150 nm rms. By stabilising the length of the 1200 m long cavity to the
pre-stabilised laser beam we achieved an error point frequency noise of 0.1
mHz/sqrt(Hz) at 100 Hz Fourier frequency. In addition we demonstrated the
reliable performance of all included subsystems by several 10-hour-periods of
continuous stable operation. Thus the full frequency stabilisation scheme for
GEO600 was successfully tested.Comment: Amaldi 4 (Perth 2001) conference proceedings, 10 pages, 8 figure
Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells
BACKGROUND: The general transcription factor TFIIB and its antagonist negative cofactor 2 (NC2) are hallmarks of RNA polymerase II (RNAPII) transcription. Both factors bind TATA box-binding protein (TBP) at promoters in a mutually exclusive manner. Dissociation of NC2 is thought to be followed by TFIIB association and subsequent preinitiation complex formation. TFIIB dissociates upon RNAPII promoter clearance, thereby providing a specific measure for steady-state preinitiation complex levels. As yet, genome-scale promoter mapping of human TFIIB has not been reported. It thus remains elusive how human core promoters contribute to preinitiation complex formation in vivo. RESULTS: We compare target genes of TFIIB and NC2 in human B cells and analyze associated core promoter architectures. TFIIB occupancy is positively correlated with gene expression, with the vast majority of promoters being GC-rich and lacking defined core promoter elements. TATA elements, but not the previously in vitro defined TFIIB recognition elements, are enriched in some 4 to 5% of the genes. NC2 binds to a highly related target gene set. Nonetheless, subpopulations show strong variations in factor ratios: whereas high TFIIB/NC2 ratios select for promoters with focused start sites and conserved core elements, high NC2/TFIIB ratios correlate to multiple start-site promoters lacking defined core elements. CONCLUSIONS: TFIIB and NC2 are global players that occupy active genes. Preinitiation complex formation is independent of core elements at the majority of genes. TATA and TATA-like elements dictate TFIIB occupancy at a subset of genes. Biochemical data support a model in which preinitiation complex but not TBP-NC2 complex formation is regulated
Optimal Alignment Sensing of a Readout Mode Cleaner Cavity
Critically coupled resonant optical cavities are often used as mode cleaners
in optical systems to improve the signal to noise ratio (SNR) of a signal that
is encoded as an amplitude modulation of a laser beam. Achieving the best SNR
requires maintaining the alignment of the mode cleaner relative to the laser
beam on which the signal is encoded. An automatic alignment system which is
primarily sensitive to the carrier field component of the beam will not, in
general, provide optimal SNR. We present an approach that modifies traditional
dither alignment sensing by applying a large amplitude modulation on the signal
field, thereby producing error signals that are sensitive to the signal
sideband field alignment. When used in conjunction with alignment actuators,
this approach can improve the detected SNR; we demonstrate a factor of 3
improvement in the SNR of a kilometer-scale detector of the Laser
Interferometer Gravitational-wave Observatory. This approach can be generalized
to other types of alignment sensors
- âŠ