Simulation of Classical Thermal States on a Quantum Computer: A Transfer Matrix Approach

We present a hybrid quantum-classical algorithm to simulate thermal states of a classical Hamiltonians on a quantum computer. Our scheme employs a sequence of locally controlled rotations, building up the desired state by adding qubits one at a time. We identify a class of classical models for which our method is efficient and avoids potential exponential overheads encountered by Grover-like or quantum Metropolis schemes. Our algorithm also gives an exponential advantage for 2D Ising models with magnetic field on a square lattice, compared with the previously known Zalka's algorithm.Comment: 5 pages, 3 figures; (new in version 2: added new figure, title changed, rearranged paragraphs

Alemtuzumab pre-conditioning with tacrolimus monotherapy in pediatric renal transplantation

We employed antibody pre-conditioning with alemtuzumab and posttransplant immunosuppression with low-dose tacrolimus monotherapy in 26 consecutive pediatric kidney transplant recipients between January 2004 and December 2005. Mean recipient age was 10.7 ± 5.8 years, 7.7% were undergoing retransplantation, and 3.8% were sensitized, with a PRA >20%. Mean donor age was 32.8 ± 9.2 years. Living donors were utilized in 65% of the transplants. Mean cold ischemia time was 27.6 ± 6.4 h. The mean number of HLA mismatches was 3.3 ± 1.3. Mean follow-up was 25 ± 8 months. One and 2 year patient survival was 100% and 96%. One and 2 year graft survival was 96% and 88%. Mean serum creatinine was 1.1 ± 0.6 mg/dL, and calculated creatinine clearance was 82.3 ± 29.4 mL/min/1.73 m 2. The incidence of pre-weaning acute rejection was 11.5%; the incidence of delayed graft function was 7.7%. Eighteen (69%) of the children were tapered to spaced tacrolimus monotherapy, 10.5 ± 2.2 months after transplantation. The incidence of CMV, PTLD and BK virus was 0%; the incidence of posttransplant diabetes was 7.7%. Although more follow-up is clearly needed, antibody pre-conditioning with alemtuzumab and tacrolimus monotherapy may be a safe and effective regimen in pediatric renal transplantation. © 2007 The Authors

Probing the face-on disc-corona system of the bare AGN Mrk 110 from UV to hard X-rays: a moderate changing-state AGN?

[Abridged] The X-ray broadband spectra of the bare AGN Mrk 110, obtained by simultaneous XMM-Newton and NuSTAR observations (Nov 2019 and April 2020), are characterised by the presence of a prominent and absorption-free smooth soft X-ray excess, moderately broad OVII and Fe Kalpha emission lines, and a lack of a strong Compton hump. While relativistic reflection as the sole emission is ruled out, a simplified combination of soft and hard Comptonisation from a warm and a hot coronae, plus mild relativistic disc reflection reproduces the data very well. We aim to confirm the physical origin of the soft X-ray excess of Mrk 110 and to determine its disc-corona system properties from its energetics using two new sophisticated models: reXcor and relagn, respectively. At both epochs, the inferred high-values of the warm-corona heating from the X-ray broadband spectral analysis using reXcor confirm that the soft X-ray excess originates mainly from a warm corona rather than relativistic reflection. The intrinsic best-fit SED determined at both epochs using relagn show a high X-ray contribution relative to the UV and are very well reproduced by a warm and hot coronae plus mild relativistic reflection. The outer radii of the hot and warm coronae are located at a few 10s and ~100 Rg, respectively. Moreover, combining the inferred low Eddington ratio (~ a few %) from this work, and previous multi-wavelength spectral and timing studies suggests that Mrk 110 could be classified as a moderate changing-state AGN. Our analysis confirms the existence of a warm corona as a significant contribution to the soft X-ray excess and UV emission in Mrk 110, adding to growing evidence that AGN accretion deviates from standard disc theory. This strengthens the importance of long-term multi-wavelength monitoring on both single targets and large AGN surveys to reveal the real nature of disc-corona system in AGN.Comment: 12 pages, 7 figures, accepted for publication in A&

Aproximaciones didácticas en el proceso educativo

Con el presente artículo, se busca dar a conocer el desarrollo parcial de la investigación intitulada “El juego en química y matemáticas, alternativa para la apatía en su aprendizaje”, adelantada en la Institución Educativa Mariano Ospina Pérez del municipio de Tinjacá, donde luego de un seguimiento a las clases de estas dos áreas se evidenció un sentir de falta de interés y desagrado por su estudio; por lo que se hizo necesario implementar un proyecto que relacionara estas áreas y cómo debería darse su enseñanza, implícito en la relación pedagógica en las instituciones educativas, para así buscar mejorar la actitud que los estudiantes tenían hacia estas. Esto a partir de acciones como charlas e interacción con los estudiantes, donde se marcó que el juego era una buena alternativa; por lo que, se procedió a crear e implementar el juego dentro del desarrollo de las clases. Así, se pudieron ver avances en la forma en que los estudiantes se desempeñaban, pues, hacerlos partícipes del proyecto y creadores de su propio material didáctico dejó ver motivación y, sobre todo, compromiso con su propia formación, lo que nos reveló que vamos por buen camino porque los aportes de esta investigación han mostrado cambios bastante marcados y, sobre todo, positivos, aunque ha pasado poco tiempo de su aplicación

Teaching cancer imaging in the era of precision medicine: Looking at the big picture

The role of imaging in cancer diagnosis and treatment has evolved at the same rapid pace as cancer management. Over the last twenty years, with the advancement of technology, oncology has become a multidisciplinary field that allows for researchers and clinicians not only to create individualized treatment options for cancer patients, but also to evaluate patients\u27 response to therapy with increasing precision. Familiarity with these concepts is a requisite for current and future radiologists, as cancer imaging studies represent a significant and growing component of any radiology practice, from tertiary cancer centers to community hospitals. In this review we provide the framework to teach cancer imaging in the era of genomic oncology. After reading this article, readers should be able to illustrate the basics cancer genomics, modern cancer genomics, to summarize the types of systemic oncologic therapies available, their patterns of response and their adverse events, to discuss the role of imaging in oncologic clinical trials and the role of tumor response criteria and to display the future directions of oncologic imaging

Antilymphoid antibody preconditioning and tacrolimus monotherapy for pediatric kidney transplantation

Objective: Heavy post-transplant immunosuppression may contribute to long-term immunosuppression dependence by subverting tolerogenic mechanisms; thus, we sought to determine if this undesirable consequence could be mitigated by pretransplant lymphoid depletion and minimalistic post-transplant monotherapy. Study design: Lymphoid depletion in 17 unselected pediatric recipients of live (n = 14) or deceased donor kidneys (n = 3) was accomplished with antithymocyte globulin (ATG) (n = 8) or alemtuzumab (n = 9). Tacrolimus was begun post-transplantation with subsequent lengthening of intervals between doses (spaced weaning). Maintenance immunosuppression, morbidity, graft function, and patient/graft survival were collated. Results: Steroids were added temporarily to treat rejection in two patients (both ATG subgroup) or to treat hemolytic anemia in two others. After 16 to 31 months (mean 22), patient and graft survival was 100% and 94%, respectively. The only graft loss was in a nonweaned noncompliant recipient. In the other 16, serum creatinine was 0.85 ± 0.35 mg/dL and creatinine clearance was 90.8 ± 22.1 mL/1.73 m2. All 16 patients are on monotherapy (15 tacrolimus, one sirolimus), and 14 receive every other day or 3 times per week doses. There were no wound or other infections. Two patients developed insulin-dependent diabetes. Conclusion: The strategy of lymphoid depletion and minimum post-transplant immunosuppression appears safe and effective for pediatric kidney recipients. © 2006 Elsevier Inc. All rights reserved

Dietary Inflammatory Index and Cardiovascular Risk and Mortality—A Meta-Analysis

Diet and chronic inflammation have been suggested to be risk factors in the development of cardiovascular disease (CVD) and related mortality. The possible link between the inflammatory potential of diet measured through the Dietary Inflammatory Index (DII®) and CVD has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from 14 studies were eligible, of which two were case-control, eleven were cohort, and one was cross-sectional. Results from the random-effects meta-analysis showed a positive association between increasing DII, indicating a pro-inflammatory diet, and CVD. Individuals in the highest versus the lowest (reference) DII category showed a 36% increased risk of CVD incidence and mortality, with moderate evidence of heterogeneity (relative risk (RR) = 1.36, 95% confidence interval (CI): 1.19, 1.57; heterogeneity index I2 = 69%, p \u3c 0.001). When analyzed as a continuous variable, results showed an increased risk of CVD risk and mortality of 8% for each one-point increase in the DII score. Results remained unchanged when analyses were restricted to the prospective studies. Results of our meta-analysis support the importance of adopting a healthier anti-inflammatory diet for preventing CVD incidence and related mortality. In conclusion, a pro-inflammatory diet is associated with increased risk of CVD and CVD mortality. These results further substantiate the utility of DII as tool to characterize the inflammatory potential of diet and to predict CVD incidence and mortality

Dietary Inflammatory Index and Colorectal Cancer Risk – A Meta-Analysis

Diet and chronic inflammation of the colon have been suggested to be risk factors in the development of colorectal cancer (CRC). The possible link between inflammatory potential of diet, measured through the Dietary Inflammatory Index (DII®), and CRC has been investigated in several populations across the world. The aim of this study was to conduct a meta-analysis on studies exploring this association. Data from nine studies were eligible, of which five were case-control and four were cohort studies. Results from meta-analysis showed a positive association between increasing DII scores, indicating a pro-inflammatory diet, and CRC. Individuals in the highest versus the lowest (reference) DII category showed an overall 40% increased risk of CRC with moderate evidence of heterogeneity [relative risk (RR) = 1.40, 95% confidence interval (CI): 1.26, 1.55; I 2 = 69%, p \u3c 0.001]. When analyzed as a continuous variable, results showed an increased risk of CRC of 7% for a 1-point increase in the DII score. Results remained unchanged when analyses were restricted to the four prospective studies. Results of our meta-analysis support the importance of adopting a healthier anti-inflammatory diet in preventing CRC. These results further substantiate the utility of DII as tool to characterize the inflammatory potential of diet and to predict CRC