Kerncraft: A Tool for Analytic Performance Modeling of Loop Kernels

Achieving optimal program performance requires deep insight into the interaction between hardware and software. For software developers without an in-depth background in computer architecture, understanding and fully utilizing modern architectures is close to impossible. Analytic loop performance modeling is a useful way to understand the relevant bottlenecks of code execution based on simple machine models. The Roofline Model and the Execution-Cache-Memory (ECM) model are proven approaches to performance modeling of loop nests. In comparison to the Roofline model, the ECM model can also describes the single-core performance and saturation behavior on a multicore chip. We give an introduction to the Roofline and ECM models, and to stencil performance modeling using layer conditions (LC). We then present Kerncraft, a tool that can automatically construct Roofline and ECM models for loop nests by performing the required code, data transfer, and LC analysis. The layer condition analysis allows to predict optimal spatial blocking factors for loop nests. Together with the models it enables an ab-initio estimate of the potential benefits of loop blocking optimizations and of useful block sizes. In cases where LC analysis is not easily possible, Kerncraft supports a cache simulator as a fallback option. Using a 25-point long-range stencil we demonstrate the usefulness and predictive power of the Kerncraft tool.Comment: 22 pages, 5 figure

The individualised needs for service assessment (INSA) for children and adolescents with serious emotional disturbance

The Individualised Needs for Service Assessment (INSA) for children and adolescents with serious emotional disturbance was developed in response to the lack of a systematic approach to needs assessment compatible with individualised service planning. Functioning is assessed for 10 functional domains. Service providers rate service provision using a taxonomy of generic service items that are generalisable and comprehensible across different organisational units and systems of care. In addition, service providers rate the anticipated clinical effectiveness of each service item and the acceptability of each item to the child or adolescent and family. Drawing on a similar logic structure to that characterising the Needs for Care Assessment of the British Medical Research Council, these data are linked to produce a need status, for example unmet need, no need and met need. The INSA may be suitable for use by service providers, planners, policy makers, researchers, managed care organisations and service purchasers

Empirical ground-motion prediction equations for Northwestern Turkey using the aftershocks of the 1999 Kocaeli earthquake

We present ground motion models for northwestern Turkey using the aftershocks of the Mw 7.4, 1999 Kocaeli earthquake. We consider 4047 velocity and acceleration records for each component of motion, from 528 earthquakes recorded by stations belonging to regional networks. The ground motion models obtained provide peak ground velocity, peak ground acceleration, and spectral accelerations for 8 different frequencies between 1 and 10 Hz. The analysis of the error distribution shows that the record-to-record component of variance is the largest contribution to the standard deviation of the calibrated ground- motion models. Furthermore, a clear dependence of inter-event error on stress drop is observed. The empirical ground-motion prediction equations, derived for both the larger horizontal and vertical components, are valid in the local magnitude range from 0.5 to 5.9, and for hypocentral distances up to 190 km. Citation: Bindi, D., S. Parolai, H. Grosser, C. Milkereit, and E. Durukal (2007), Empirical ground-motion prediction equations for northwestern Turkey using the aftershocks of the 1999 Kocaeli earthquake

Nonadiabatic transitions in the exit channel of atom-molecule collisions: Fine-structure branching in Na+N[sub 2]

We study Na+N₂collisions by laser excitation of the collision complex in a differential scattering experiment. The measured relative population of the Na(3p) fine-structure levels reflects the nonadiabatic transitions occuring in the exit channel of the collision.Theoretical results obtained with a classical-path formalism and accurate quantum chemical data for NaN₂ are found to be in good agreement. The presence of a conical intersection for the T-shaped geometry has a profound influence on the observed fine-structure branching.Support from the Deutsche Forschungsgemeinschaft is gratefully acknowledged

Source parameters and seismic moment-magnitude scaling for Northwestern Turkey

Abstract The source parameters of 523 aftershocks (0.5 ML 5.9) of the 1999 Kocaeli earthquake are determined by performing a two-step spectral fitting procedure. The source spectrum, corrected for both site and propagation effects, is described in terms of a standard x-square model multiplied by an exponential term of frequency. The latter term is introduced to estimate the high-frequency (f 12 Hz) fall-off of the acceleration source spectra by computing the j parameter. The seismic moments obtained range between 1.05 1014 and 2.41 1017 N m, whereas the Brune stress drops are between 0.002 and 40 MPa. The j value varies between 0.00 and 0.08 sec, indicating a decay of the acceleration level at the higher frequency part of the spectrum greater than that assumed by the x 2 model. Both the stress drop and the j parameter show the tendency of increasing with aftershock magnitude. No evidence of self-similarity breakdown is observed between the source radius and M0. Finally, both the seismic moment and the moment magnitude are compared with the local magnitude to derive new moment–magnitude relationships for the area

Regularity properties of distributions through sequences of functions

We give necessary and sufficient criteria for a distribution to be smooth or uniformly H\"{o}lder continuous in terms of approximation sequences by smooth functions; in particular, in terms of those arising as regularizations $(T\ast\phi_{n})$.Comment: 10 page

Classes of generalized functions with finite type regularities

We introduce and analyze spaces and algebras of generalized functions which correspond to Hölder, Zygmund, and Sobolev spaces of functions. The main scope of the paper is the characterization of the regularity of distributions that are embedded into the corresponding space or algebra of generalized functions with finite type regularities

First record of Erpobdella concolor (Annandale, 1913) (Hirudinida: Erpobdellidae) from Greece

Erpobdella concolor (Annandale, 1913) was recorded for the first time from a spring in the Peloponnese, Greece. This locality represents the westernmost spot of the species range known so far

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration

Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 overexpression models supports a role for SOD1 toxic gain of function in ALS pathogenesis. However, the impact of SOD1 loss of function in ALS cannot be directly examined in overexpression models. In addition, overexpression may obscure the contribution of SOD1 loss of function in the degeneration of different neuronal populations. Here, we report the first single-copy, ALS knock-in models in C. elegans generated by transposon- or CRISPR/Cas9- mediated genome editing of the endogenous sod-1 gene. Introduction of ALS patient amino acid changes A4V, H71Y, L84V, G85R or G93A into the C. elegans sod-1 gene yielded single-copy/knock-in ALS SOD1 models. These differ from previously reported overexpression models in multiple assays. In single-copy/knock-in models, we observed differential impact of sod-1 ALS alleles on glutamatergic and cholinergic neurodegeneration. A4V, H71Y, G85R, and G93A animals showed increased SOD1 protein accumulation and oxidative stress induced degeneration, consistent with a toxic gain of function in cholinergic motor neurons. By contrast, H71Y, L84V, and G85R lead to glutamatergic neuron degeneration due to sod-1 loss of function after oxidative stress. However, dopaminergic and serotonergic neuronal populations were spared in single-copy ALS models, suggesting a neuronal-subtype specificity previously not reported in invertebrate ALS SOD1 models. Combined, these results suggest that knock-in models may reproduce the neurotransmitter-type specificity of ALS and that both SOD1 loss and gain of toxic function differentially contribute to ALS pathogenesis in different neuronal populations.Peer reviewe

On the Geroch-Traschen class of metrics

We compare two approaches to semi-Riemannian metrics of low regularity. The maximally 'reasonable' distributional setting of Geroch and Traschen is shown to be consistently contained in the more general setting of nonlinear distributional geometry in the sense of Colombea