2,557 research outputs found
QCD with Chemical Potential in a Small Hyperspherical Box
To leading order in perturbation theory, we solve QCD, defined on a small
three sphere in the large N and Nf limit, at finite chemical potential and map
out the phase diagram in the (mu,T) plane. The action of QCD is complex in the
presence of a non-zero quark chemical potential which results in the sign
problem for lattice simulations. In the large N theory, which at low
temperatures becomes a conventional unitary matrix model with a complex action,
we find that the dominant contribution to the functional integral comes from
complexified gauge field configurations. For this reason the eigenvalues of the
Polyakov line lie off the unit circle on a contour in the complex plane. We
find at low temperatures that as mu passes one of the quark energy levels there
is a third-order Gross-Witten transition from a confined to a deconfined phase
and back again giving rise to a rich phase structure. We compare a range of
physical observables in the large N theory to those calculated numerically in
the theory with N=3. In the latter case there are no genuine phase transitions
in a finite volume but nevertheless the observables are remarkably similar to
the large N theory.Comment: 44 pages, 18 figures, jhep3 format. Small corrections and
clarifications added in v3. Conclusions cleaned up. Published versio
Large-N spacetime reduction and the sign and silver-blaze problems of dense QCD
We study the spacetime-reduced (Eguchi-Kawai) version of large-N QCD with
nonzero chemical potential. We explore a method to suppress the sign
fluctuations of the Dirac determinant in the hadronic phase; the method employs
a re-summation of gauge configurations that are related to each other by center
transformations. We numerically test this method in two dimensions, and find
that it successfully solves the silver-blaze problem. We analyze the system
further, and measure its free energy F, the average phase theta of its Dirac
determinant, and its chiral condensate . We show that F and
are independent of mu in the hadronic phase but that, as chiral
perturbation theory predicts, the quenched chiral condensate drops from its
mu=0 value when mu~(pion mass)/2. Finally, we find that the distribution of
theta qualitatively agrees with further, more recent, predictions from chiral
perturbation theory.Comment: 43 pages, 17 figure
Chiral Modulations in Curved Space I: Formalism
The goal of this paper is to present a formalism that allows to handle
four-fermion effective theories at finite temperature and density in curved
space. The formalism is based on the use of the effective action and zeta
function regularization, supports the inclusion of inhomogeneous and
anisotropic phases. One of the key points of the method is the use of a
non-perturbative ansatz for the heat-kernel that returns the effective action
in partially resummed form, providing a way to go beyond the approximations
based on the Ginzburg-Landau expansion for the partition function. The
effective action for the case of ultra-static Riemannian spacetimes with
compact spatial section is discussed in general and a series representation,
valid when the chemical potential satisfies a certain constraint, is derived.
To see the formalism at work, we consider the case of static Einstein spaces at
zero chemical potential. Although in this case we expect inhomogeneous phases
to occur only as meta-stable states, the problem is complex enough and allows
to illustrate how to implement numerical studies of inhomogeneous phases in
curved space. Finally, we extend the formalism to include arbitrary chemical
potentials and obtain the analytical continuation of the effective action in
curved space.Comment: 22 pages, 3 figures; version to appear in JHE
Gauge invariant definition of the jet quenching parameter
In the framework of Soft-Collinear Effective Theory, the jet quenching
parameter, , has been evaluated by adding the effect of Glauber gluon
interactions to the propagation of a highly-energetic collinear parton in a
medium. The result, which holds in covariant gauges, has been expressed in
terms of the expectation value of two Wilson lines stretching along the
direction of the four-momentum of the parton. In this paper, we show how that
expression can be generalized to an arbitrary gauge by the addition of
transverse Wilson lines. The transverse Wilson lines are explicitly computed by
resumming interactions of the parton with Glauber gluons that appear only in
non-covariant gauges. As an application of our result, we discuss the
contribution to coming from transverse momenta of order in a
medium that is a weakly-coupled quark-gluon plasma.Comment: 31 pages, 7 figures; journal versio
Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV Core DII protein
Host cell lipid droplets (LD) are essential in the hepatitis C virus (HCV) life cycle and are targeted by the viral capsid core protein. Core-coated LDs accumulate in the perinuclear region and facilitate viral particle assembly, but it is unclear how mobility of these LDs is directed by core. Herein we used two-photon fluorescence, differential interference contrast imaging, and coherent anti-Stokes Raman scattering microscopies, to reveal novel core-mediated changes to LD dynamics. Expression of core proteinâs lipid binding domain II (DII-core) induced slower LD speeds, but did not affect directionality of movement on microtubules. Modulating the LD binding strength of DII-core further impacted LD mobility, revealing the temporal effects of LD-bound DII-core. These results for DII-core coated LDs support a model for core-mediated LD localization that involves core slowing down the rate of movement of LDs until localization at the perinuclear region is accomplished where LD movement ceases. The guided localization of LDs by HCV core protein not only is essential to the viral life cycle but also poses an interesting target for the development of antiviral strategies against HCV
The deuteron: structure and form factors
A brief review of the history of the discovery of the deuteron in provided.
The current status of both experiment and theory for the elastic electron
scattering is then presented.Comment: 80 pages, 33 figures, submited to Advances in Nuclear Physic
Effective action in a higher-spin background
We consider a free massless scalar field coupled to an infinite tower of
background higher-spin gauge fields via minimal coupling to the traceless
conserved currents. The set of Abelian gauge transformations is deformed to the
non-Abelian group of unitary operators acting on the scalar field. The gauge
invariant effective action is computed perturbatively in the external fields.
The structure of the various (divergent or finite) terms is determined. In
particular, the quadratic part of the logarithmically divergent (or of the
finite) term is expressed in terms of curvatures and related to conformal
higher-spin gravity. The generalized higher-spin Weyl anomalies are also
determined. The relation with the theory of interacting higher-spin gauge
fields on anti de Sitter spacetime via the holographic correspondence is
discussed.Comment: 40 pages, Some errors and typos corrected, Version published in JHE
Present day greenhouse gases could cause more frequent and longer Dust Bowl heatwaves
Substantial warming occurred across North America, Europe and the Arctic over the early twentieth century1, including an increase in global drought2, that was partially forced by rising greenhouse gases (GHGs)3. The period included the 1930s Dust Bowl drought4,5,6,7 across North Americaâs Great Plains that caused widespread crop failures4,8, large dust storms9 and considerable out-migration10. This coincided with the central United States experiencing its hottest summers of the twentieth century11,12 in 1934 and 1936, with over 40 heatwave days and maximum temperatures surpassing 44â°C at some locations13,14. Here we use a large-ensemble regional modelling framework to show that GHG increases caused slightly enhanced heatwave activity over the eastern United States during 1934 and 1936. Instead of asking how a present-day heatwave would behave in a world without climate warming, we ask how these 1930s heatwaves would behave with present-day GHGs. Heatwave activity in similarly rare events would be much larger under todayâs atmospheric GHG forcing and the return period of a 1-in-100-year heatwave summer (as observed in 1936) would be reduced to about 1-in-40âyears. A key driver of the increasing heatwave activity and intensity is reduced evaporative cooling and increased sensible heating during dry springs and summers
Analogue peptides for the immunotherapy of human acute myeloid leukemia
Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies
What Is the Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in Excluding Prostate Cancer at Biopsy? A Systematic Review and Meta-analysis from the European Association of Urology Prostate Cancer Guidelines Panel
Context: It remains unclear whether patients with a suspicion of prostate cancer (PCa) and negative multiparametric magnetic resonance imaging (mpMRI) can safely obviate prostate biopsy. Objective: To systematically review the literature assessing the negative predictive value (NPV) of mpMRI in patients with a suspicion of PCa. Evidence acquisition: The Embase, Medline, and Cochrane databases were searched up to February 2016. Studies reporting prebiopsy mpMRI results using transrectal or transperineal biopsy as a reference standard were included. We further selected for meta-analysis studies with at least 10-core biopsies as the reference standard, mpMRI comprising at least T2-weighted and diffusion-weighted imaging, positive mpMRI defined as a Prostate Imaging Reporting Data System/Likert score of â„3/5 or â„4/5, and results reported at patient level for the detection of overall PCa or clinically significant PCa (csPCa) defined as Gleason â„7 cancer. Evidence synthesis: A total of 48 studies (9613 patients) were eligible for inclusion. At patient level, the median prevalence was 50.4% (interquartile range [IQR], 36.4â57.7%) for overall cancer and 32.9% (IQR, 28.1â37.2%) for csPCa. The median mpMRI NPV was 82.4% (IQR, 69.0â92.4%) for overall cancer and 88.1% (IQR, 85.7â92.3) for csPCa. NPV significantly decreased when cancer prevalence increased, for overall cancer (r = â0.64, p < 0.0001) and csPCa (r = â0.75, p = 0.032). Eight studies fulfilled the inclusion criteria for meta-analysis. Seven reported results for overall PCa. When the overall PCa prevalence increased from 30% to 60%, the combined NPV estimates decreased from 88% (95% confidence interval [95% CI], 77â99%) to 67% (95% CI, 56â79%) for a cut-off score of 3/5. Only one study selected for meta-analysis reported results for Gleason â„7 cancers, with a positive biopsy rate of 29.3%. The corresponding NPV for a cut-off score of â„3/5 was 87.9%. Conclusions: The NPV of mpMRI varied greatly depending on study design, cancer prevalence, and definitions of positive mpMRI and csPCa. As cancer prevalence was highly variable among series, risk stratification of patients should be the initial step before considering prebiopsy mpMRI and defining those in whom biopsy may be omitted when the mpMRI is negative. Patient summary This systematic review examined if multiparametric magnetic resonance imaging (MRI) scan can be used to reliably predict the absence of prostate cancer in patients suspected of having prostate cancer, thereby avoiding a prostate biopsy. The results suggest that whilst it is a promising tool, it is not accurate enough to replace prostate biopsy in such patients, mainly because its accuracy is variable and influenced by the prostate cancer risk. However, its performance can be enhanced if there were more accurate ways of determining the risk of having prostate cancer. When such tools are available, it should be possible to use an MRI scan to avoid biopsy in patients at a low risk of prostate cancer
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