55 research outputs found
An Algorithm to Minimize Energy Consumption and Elapsed Time for IoT Workloads in a Hybrid Architecture
N/
The Collective Field Theory of a Singular Supersymmetric Matrix Model
The supersymmetric collective field theory with the potential is studied, motivated by the matrix model proposed by Jevicki
and Yoneya to describe two dimensional string theory in a black hole
background. Consistency with supersymmetry enforces a two band solution. A
supersymmetric classical configuration is found, and interpreted in terms of
the density of zeros of certain Laguerre polynomials. The spectrum of the model
is then studied and is seen to correspond to a massless scalar and a majorana
fermion. The space eigenfunctions are constructed and expressed in terms of
Chebyshev polynomials. Higher order interactions are also discussed.Comment: Revtex 8 pages, Submitted to Phys. Rev. D. References and preprint
numbers have been adde
Systematic corrections for bosonic and fermionic vector models without auxiliary fields
In this paper, colorless bilocal fields are employed to study the large
limit of both fermionic and bosonic vector models. The Jacobian associated with
the change of variables from the original fields to the bilocals is computed
exactly, thereby providing an exact effective action. This effective action is
shown to reproduce the familiar perturbative expansion for the two and four
point functions. In particular, in the case of fermionic vector models, the
effective action correctly accounts for the Fermi statistics. The theory is
also studied non-perturbatively. The stationary points of the effective action
are shown to provide the usual large gap equations. The homogeneous
equation associated with the quadratic (in the bilocals) action is simply the
two particle Bethe Salpeter equation. Finally, the leading correction in
is shown to be in agreement with the exact matrix of the model.Comment: 24 pages, uses REVTEX macros. Replaced with final version to appear
in Phys. Rev.
Modeling bursts and heavy tails in human dynamics
Current models of human dynamics, used from risk assessment to
communications, assume that human actions are randomly distributed in time and
thus well approximated by Poisson processes. We provide direct evidence that
for five human activity patterns the timing of individual human actions follow
non-Poisson statistics, characterized by bursts of rapidly occurring events
separated by long periods of inactivity. We show that the bursty nature of
human behavior is a consequence of a decision based queuing process: when
individuals execute tasks based on some perceived priority, the timing of the
tasks will be heavy tailed, most tasks being rapidly executed, while a few
experiencing very long waiting times. We discuss two queueing models that
capture human activity. The first model assumes that there are no limitations
on the number of tasks an individual can hadle at any time, predicting that the
waiting time of the individual tasks follow a heavy tailed distribution with
exponent alpha=3/2. The second model imposes limitations on the queue length,
resulting in alpha=1. We provide empirical evidence supporting the relevance of
these two models to human activity patterns. Finally, we discuss possible
extension of the proposed queueing models and outline some future challenges in
exploring the statistical mechanisms of human dynamics.Comment: RevTex, 19 pages, 8 figure
Telomerase promoter mutations in cancer: an emerging molecular biomarker?
João Vinagre, Vasco Pinto and Ricardo Celestino contributed equally to
the manuscript.Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomerase reactivation, such immortalization could be due to telomere maintenance through the “alternative mechanism of telomere lengthening” (ALT) but the mechanisms underlying both forms of reactivation remained elusive. Mutations in the coding region of telomerase gene are very rare in the cancer setting, despite being associated with some degenerative diseases. Recently, mutations in telomerase (TERT) gene promoter were found in sporadic and familial melanoma and subsequently in several cancer models, notably in gliomas, thyroid cancer and bladder cancer. The importance of these findings has been reinforced by the association of TERT mutations in some cancer types with tumour aggressiveness and patient survival. In the first part of this review, we summarize the data on the biology of telomeres and telomerase, available methodological approaches and non-neoplastic diseases associated with telomere dysfunction. In the second part, we review the information on telomerase expression and genetic alterations in the most relevant types of cancer (skin, thyroid, bladder and central nervous system) on record, and discuss the value of telomerase as a new biomarker with impact on the prognosis and survival of the patients and as a putative therapeutic target
Neurocysticercosis, familial cerebral cavernomas and intracranial calcifications: differential diagnosis for adequate management
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Global variations in diabetes mellitus based on fasting glucose and haemogloblin A1c
Fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) are both used to diagnose
diabetes, but may identify different people as having diabetes. We used data from 117
population-based studies and quantified, in different world regions, the prevalence of
diagnosed diabetes, and whether those who were previously undiagnosed and detected
as having diabetes in survey screening had elevated FPG, HbA1c, or both. We developed
prediction equations for estimating the probability that a person without previously
diagnosed diabetes, and at a specific level of FPG, had elevated HbA1c, and vice versa.
The age-standardised proportion of diabetes that was previously undiagnosed, and
detected in survey screening, ranged from 30% in the high-income western region to 66%
in south Asia. Among those with screen-detected diabetes with either test, the agestandardised
proportion who had elevated levels of both FPG and HbA1c was 29-39%
across regions; the remainder had discordant elevation of FPG or HbA1c. In most low- and
middle-income regions, isolated elevated HbA1c more common than isolated elevated
FPG. In these regions, the use of FPG alone may delay diabetes diagnosis and
underestimate diabetes prevalence. Our prediction equations help allocate finite
resources for measuring HbA1c to reduce the global gap in diabetes diagnosis and
surveillance.peer-reviewe
- …