Emotion in the German Lutheran Baroque and the development of subjective time consciousness

This study examines some of the ways in which it was possible to understand emotion in Lutheran church music of the seventeenth and early eighteenth centuries. It suggests that emotion related to music more through association and contextual factors than through a fixed relationship, thus explaining the ways in which musical passages and techniques could be taken from a secular context to serve a sacred purpose. With these factors in mind, it is possible to suggest ways in which a listener's likely emotional association with music can be harnessed through particular compositional procedures. Schütz's setting of part of the Song of Songs may well engage with the listener's consciousness over time, stretching it and reinforcing the ‘useful’ emotional associations that the sacred context might bring. The opening aria of Bach's cantata ‘Liebster Jesu, mein Verlangen’ achieves something similar over a longer span and with greater emotional intensity. Here there is the added sense of the believer finding, losing and then rediscovering the object of spiritual adoration. The music thus implies the potential alienation of the listener, something both supported and overcome through the very structuring of the music. Its repetitive ritornello process is sometimes hidden but always latent, thus playing on the potential for subconscious recognition. Together, these two examples suggest that music can be used as a powerful demonstration of the historical development of modern forms of consciousness as related to emotional states over time

Blood platelet response to plasma from patients with ischemic heart disease

Blood platelets change shape (from small round spheres to larger spread forms) as they participate in thrombosis. Using an electron microscopic technique, we surveyed 14 patients with both acute and chronic ischemic heart disease; each had increased spread platelet forms (69 +/- 22.2 [standard deviation] percent) when compared with 14 asymptomatic control subjects (P P P Thus a factor existed in the plasma of these patients with ischemic heart disease that caused normal platelets to become spread. Similarly the plasma of some patients with serious noncardiac disease had a comparable effect on normal platelets. Although the identity of this factor is unknown, it is probably unrelated to hormonal or therapeutic influences occurring either during acute infarction or during the stress of serious illness because (1) the effect of the plasma from patients with acute ischemic heart disease was identical to that of patients with chronic ischemic heart disease, and (2) the effect was not present in all patients with serious noncardiac disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22135/1/0000564.pd

Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein

We have previously reported that the CDX1 homeoprotein interacts with the TATA-box binding protein (TBP) on the promoter of the glucose-6-phosphatase (G6Pase) gene. We show here that CDX1 interacts with TBP via the homeodomain and that the transcriptional activity additionally requires the N-terminal domain upstream of the homeodomain. CDX1 interacting with TBP is connected to members of the TFIID and Mediator complexes, two major elements of the general transcriptional machinery. Transcription luciferase assays performed using an altered-specificity mutant of TBP provide evidence for the functionality of the interaction between CDX1 and TBP. Unlike CDX1, CDX2 does not interact with TBP nor does it transactivate the G6Pase promoter. Swapping experiments between the domains of CDX1 and CDX2 indicate that, despite opposite functional effects of the homeoproteins on the G6Pase promoter, the N-terminal domains and homeodomains of both CDX1 and CDX2 have the intrinsic ability to activate transcription and to interact with TBP. However, the carboxy domains define the specificity of CDX1 and CDX2. Thus, intra-molecular interactions control the activity and partner recruitment of CDX1 and CDX2, leading to different molecular functions

Development of six PROMIS pediatrics proxy-report item banks

<p>Abstract</p> <p>Background</p> <p>Pediatric self-report should be considered the standard for measuring patient reported outcomes (PRO) among children. However, circumstances exist when the child is too young, cognitively impaired, or too ill to complete a PRO instrument and a proxy-report is needed. This paper describes the development process including the proxy cognitive interviews and large-field-test survey methods and sample characteristics employed to produce item parameters for the Patient Reported Outcomes Measurement Information System (PROMIS) pediatric proxy-report item banks.</p> <p>Methods</p> <p>The PROMIS pediatric self-report items were converted into proxy-report items before undergoing cognitive interviews. These items covered six domains (physical function, emotional distress, social peer relationships, fatigue, pain interference, and asthma impact). Caregivers (n = 25) of children ages of 5 and 17 years provided qualitative feedback on proxy-report items to assess any major issues with these items. From May 2008 to March 2009, the large-scale survey enrolled children ages 8-17 years to complete the self-report version and caregivers to complete the proxy-report version of the survey (n = 1548 dyads). Caregivers of children ages 5 to 7 years completed the proxy report survey (n = 432). In addition, caregivers completed other proxy instruments, PedsQL™ 4.0 Generic Core Scales Parent Proxy-Report version, PedsQL™ Asthma Module Parent Proxy-Report version, and KIDSCREEN Parent-Proxy-52.</p> <p>Results</p> <p>Item content was well understood by proxies and did not require item revisions but some proxies clearly noted that determining an answer on behalf of their child was difficult for some items. Dyads and caregivers of children ages 5-17 years old were enrolled in the large-scale testing. The majority were female (85%), married (70%), Caucasian (64%) and had at least a high school education (94%). Approximately 50% had children with a chronic health condition, primarily asthma, which was diagnosed or treated within 6 months prior to the</p> <p>interview. The PROMIS proxy sample scored similar or better on the other proxy instruments compared to normative samples.</p> <p>Conclusions</p> <p>The initial calibration data was provided by a diverse set of caregivers of children with a variety of common chronic illnesses and racial/ethnic backgrounds. The PROMIS pediatric proxy-report item banks include physical function (mobility n = 23; upper extremity n = 29), emotional distress (anxiety n = 15; depressive symptoms n = 14; anger n = 5), social peer relationships (n = 15), fatigue (n = 34), pain interference (n = 13), and asthma impact (n = 17).</p

GM crops on trial: technological development as a real-world experiment

Through the European controversy over agricultural biotechnology, genetically modified (GM) crops have been evaluated for an increasingly wide range of potential effects. As the experimental phase has been extended into commercial practices, the terms for product approval have become more negotiable and contentious. To analyse the regulatory conflicts, this paper links three theoretical perspectives: issue-framing, agri-environmental discourses, and technological development as a real-world experiment. Agri-biotechnological risks have been framed by contending discourses which attribute moral meanings to the agricultural environment. Agri-biotech proponents have emphasised eco-efficiency benefits which can remedy past environmental damage, while critics have framed 'uncontrollable risks' in successively broader ways through ominous metaphors of environmental catastrophe. Regulatory authorities have translated those metaphors into measurable biophysical effects. They anticipate and design commercial use as a 'real-world experiment', by assigning greater moral-legal responsibility to agro-industrial operators who handle GM products. Expert-regulatory debate reflexively considers the social discipline necessary to prevent harm, now more broadly defined than before. Official procedures undergo tensions between predicting, testing and prescribing operator behaviour. In effect, GM crops have been kept continuously 'on trial'

Superradiance and Phase Multistability in Circuit Quantum Electrodynamics

By modeling the coupling of multiple superconducting qubits to a single cavity in the circuit-quantum electrodynamics (QED) framework we find that it should be possible to observe superradiance and phase multistability using currently available technology. Due to the exceptionally large couplings present in circuit-QED we predict that superradiant microwave pulses should be observable with only a very small number of qubits (just three or four), in the presence of energy relaxation and non-uniform qubit-field coupling strengths. This paves the way for circuit-QED implementations of superradiant state readout and decoherence free subspace state encoding in subradiant states. The system considered here also exhibits phase multistability when driven with large field amplitudes, and this effect may have applications for collective qubit readout and for quantum feedback protocols.Comment: Published Versio

Application of combined omics platforms to accelerate biomedical discovery in diabesity

Diabesity has become a popular term to describe the specific form of diabetes that develops late in life and is associated with obesity. While there is a correlation between diabetes and obesity, the association is not universally predictive. Defining the metabolic characteristics of obesity that lead to diabetes, and how obese individuals who develop diabetes different from those who do not, are important goals. The use of large-scale omics analyses (e.g., metabolomic, proteomic, transcriptomic, and lipidomic) of diabetes and obesity may help to identify new targets to treat these conditions. This report discusses how various types of omics data can be integrated to shed light on the changes in metabolism that occur in obesity and diabetes

Off-Diagonal Deformations of Kerr Metrics and Black Ellipsoids in Heterotic Supergravity

Geometric methods for constructing exact solutions of motion equations with first order $\alpha ^{\prime}$ corrections to the heterotic supergravity action implying a non-trivial Yang-Mills sector and six dimensional, 6-d, almost-K\"ahler internal spaces are studied. In 10-d spacetimes, general parametrizations for generic off-diagonal metrics, nonlinear and linear connections and matter sources, when the equations of motion decouple in very general forms are considered. This allows us to construct a variety of exact solutions when the coefficients of fundamental geometric/physical objects depend on all higher dimensional spacetime coordinates via corresponding classes of generating and integration functions, generalized effective sources and integration constants. Such generalized solutions are determined by generic off-diagonal metrics and nonlinear and/or linear connections. In particular, as configurations which are warped/compactified to lower dimensions and for Levi-Civita connections. The corresponding metrics can have (non) Killing and/or Lie algebra symmetries and/or describe (1+2)-d and/or (1+3)-d domain wall configurations, with possible warping nearly almost-K\"ahler manifolds, with gravitational and gauge instantons for nonlinear vacuum configurations and effective polarizations of cosmological and interaction constants encoding string gravity effects. A series of examples of exact solutions describing generic off-diagonal supergravity modifications to black hole/ ellipsoid and solitonic configurations are provided and analyzed. We prove that it is possible to reproduce the Kerr and other type black solutions in general relativity (with certain types of string corrections) in 4-d and to generalize the solutions to non-vacuum configurations in (super) gravity/ string theories.Comment: latex2e, 44 pages with table of content, v2 accepted to EJPC with minor typos modifications requested by editor and referee and up-dated reference

Investigation of creep behaviours of gypsum specimens with flaws under different uniaxial loads

The aim of this study is to identify the influence of the dip angle of a pre-existing macrocrack on the lifetime and ultimate deformation of rock-like material. Prediction of lifetime has been studied for three groups of specimens under axial static compressive load levels. The specimens were investigated from 65% to 85% of UCS (uniaxial compressive strength) at an interval of 10% of UCS for the groups of specimens with a single modelled open flaw with a dip angle to the loading direction of 30° (first group), at an interval of 5% of UCS increment for the groups of specimens with single (second group), and double sequential open flaws with a dip angle to the loading direction of 60° (third group). This study shows that crack propagation in specimens with a single flaw follows the same sequences. At first, wing cracks appear, and then shear crack develops from the existing wing cracks. Shear cracking is responsible for specimen failure in all three groups. A slip is expected in specimens from the third group which connects two individual modelled open flaws. The moment of the slip is noticed as a characteristic rise in the axial deformation at a constant load level. It is also observed that axial deformation versus time follows the same pattern, irrespective of local geometry. Specimens from the first group exhibit higher axial deformation under different load levels in comparison with the specimens from the second and third groups