Adrenal Function in Women with Idiopathic Acne

The adrenal secretion of androgens was examined in 9 women (ages 19–39 yr) with postadolescent idiopathic acne and compared to age and sex-matched normal controls. Plasma dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), androstenedione (Δ4-A), cortisol, 17-hydroxyprogesterone, 11-deoxycortisol, and testosterone were measured by radioimmunoassay in the basal state and during a 48hr ACTH infusion. The mean plasma and time-integrated plasma levels of the 3 adrenal androgens in patients with acne were 15–25% higher than normal controls, but the groups were not significantly different (p > .05). The plasma testosterone values, on the other hand, were similar in both groups. In addition, cortisol, 11-deoxycortisol and 17-hydroxyprogesterone basal plasma values and responses to ACTH in patients with acne were similar to the normal control values. These findings suggest that adrenal androgen secretion is at most mildly elevated in patients with idiopathic acne and is unlikely to be the sole cause of acne since many patients without acne have similar hormone levels. Increased sensitivity of the sebaceous gland to androgens or increased local metabolism of androgen hormones in the skin to potent androgen metabolites may offer alternative mechanisms for the pathogenesis of this disorder

Domestication history and geographical adaptation inferred from a SNP map of African rice

African rice (Oryza glaberrima Steud.) is a cereal crop species closely related to Asian rice (Oryza sativa L.) but was independently domesticated in West Africa-3,000 years ago. African rice is rarely grown outside sub-Saharan Africa but is of global interest because of its tolerance to abiotic stresses. Here we describe a map of 2.32 million SNPs of African rice from whole-genome resequencing of 93 landraces. Population genomic analysis shows a population bottleneck in this species that began-13,000-15,000 years ago with effective population size reaching its minimum value-3,500 years ago, suggesting a protracted period of population size reduction likely commencing with predomestication management and/or cultivation. Genome-wide association studies (GWAS) for six salt tolerance traits identify 11 significant loci, 4 of which are within-300 kb of genomic regions that possess signatures of positive selection, suggesting adaptive geographical divergence for salt tolerance in this species

Microsatellite Support for Active Inbreeding in a Cichlid Fish

In wild animal populations, the degree of inbreeding differs between species and within species between populations. Because mating with kin often results in inbreeding depression, observed inbreeding is usually regarded to be caused by limited outbreeding opportunities due to demographic factors like small population size or population substructuring. However, theory predicts inclusive benefits from mating with kin, and thus part of the observed variation in inbreeding might be due to active inbreeding preferences. Although some recent studies indeed report kin mating preferences, the evidence is still highly ambiguous. Here, we investigate inbreeding in a natural population of the West African cichlid fish Pelvicachromis taeniatus which showed clear kin mating preferences in standardized laboratory experiments but no inbreeding depression. The presented microsatellite analysis reveals that the natural population has, in comparison to two reference populations, a reduced allelic diversity (A = 3) resulting in a low heterozygosity (Ho = 0.167) pointing to a highly inbred population. Furthermore, we found a significant heterozygote deficit not only at population (Fis = 0.116) but also at subpopulation level (Fis = 0.081) suggesting that inbreeding is not only a by-product of population substructuring but possibly a consequence of behavioral kin preferences

Repeated Lake-Stream Divergence in Stickleback Life History within a Central European Lake Basin

Life history divergence between populations inhabiting ecologically distinct habitats might be a potent source of reproductive isolation, but has received little attention in the context of speciation. We here test for life history divergence between threespine stickleback inhabiting Lake Constance (Central Europe) and multiple tributary streams. Otolith analysis shows that lake fish generally reproduce at two years of age, while their conspecifics in all streams have shifted to a primarily annual life cycle. This divergence is paralleled by a striking and consistent reduction in body size and fecundity in stream fish relative to lake fish. Stomach content analysis suggests that life history divergence might reflect a genetic or plastic response to pelagic versus benthic foraging modes in the lake and the streams. Microsatellite and mitochondrial markers further reveal that life history shifts in the different streams have occurred independently following the colonization by Lake Constance stickleback, and indicate the presence of strong barriers to gene flow across at least some of the lake-stream habitat transitions. Given that body size is known to strongly influence stickleback mating behavior, these barriers might well be related to life history divergence

Mass movements in cave sediments: investigation of a ~40,000-year-old guano mudflow inside the entrance of the Great Cave of Niah, Sarawak, Borneo

The West Mouth of the Great Cave at Niah in Sarawak, northwest Borneo and the North Passage that leads to the West Mouth contain large deposits of guano. The main deposit, several metres thick in places, forms the sloping floor of the entire North Passage. A mass movement deposit identified in the West Mouth, having a volume of 600 m3, originated as a guano mudflow up the North Passage in the order of 40,000 years ago. This failure of the guano slope was investigated to determine whether particular conditions or events could be identified as the most likely causes. The physical, hydrological and geotechnical properties of samples of the material were determined so that the stability of the slope could be assessed. Stability analyses showed that shearing failure of the slope would require inputs of water to the slope in quantities for which no feasible explanation can be suggested. However, the properties of the guano are similar to those of loess, indicating a high susceptibility to ‘hydrocollapse’. Very shallow failure of the slope, possibly as several smaller mudflows, could therefore have occurred due to additional water in quantities that could realistically be supplied as rainwater spray, possibly with a seismic trigger. The climate must therefore have been wetter than it is at present. These findings have implications for the interpretation of sediment deposits in other relict caves

A Further Examination of the Liberation Hypothesis in Capital Murder Trials

The liberation hypothesis argues that the effects of extra-legal factors such as victim and/or offender race on sentencing outcomes are conditioned by legally relevant factors, particularly the severity or the strength of the case. Where the evidence is weak or contradictory or the offense is less severe, decision makers are most liberated to use extra-legal factors in reaching their decisions. This study uses data on a large sample of capital murder trials in North Carolina from 1977 to 2009 to test this hypothesis. The results show that the effects of extra-legal factors (specifically, the race of offender–race of victim dyad) vary across levels of offense severity, but in a complex manner. Most notably, Black defendant–White victim dyads demonstrated an increased probability of death sentences at high levels of severity, but decreased probabilities at lower levels of severity