Food systems governance e-course – SHiFT work package 5 evaluation report

The food systems approach is increasingly being used to understand the dynamics of how food is produced and consumed, with an optimal outcome for human health, social justice, economic endeavors, and the preservation of planetary resources. Since the United Nations Food Systems Summit (UNFSS) in September 2021, the food systems approach has become central to policy and practice of many international development and research organizations, multilateral organizations, and in (national) programs and policies aiming at improving food and nutrition security

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

SummarySuccessful immunogenic apoptosis in experimental cancer therapy depends on the induction of strong host anti-tumor responses. Given that tumors are often resistant to apoptosis, it is important to identify alternative molecular mechanisms that elicit immunogenic cell death. We have developed a genetic model in which direct dimerization of FADD combined with inducible expression of RIPK3 promotes necroptosis. We report that necroptotic cancer cells release damage-associated molecular patterns and promote maturation of dendritic cells, the cross-priming of cytotoxic T cells, and the production of IFN-γ in response to tumor antigen stimulation. Using both FADD-dependent and FADD-independent RIPK3 induction systems, we demonstrate the efficient vaccination potential of immunogenic necroptotic cells. Our study broadens the current concept of immunogenic cell death and opens doors for the development of new strategies in cancer therapy

Voltage scanning and technical upgrades at the Collinear Resonance Ionization Spectroscopy experiment

To optimize the performance of the Collinear Resonance Ionization Spectroscopy (CRIS) experiment at CERN-ISOLDE, technical upgrades are continuously introduced, aiming to enhance its sensitivity, precision, stability, and efficiency. Recently, a voltage-scanning setup was developed and commissioned at CRIS, which improved the scanning speed by a factor of three as compared to the current laser-frequency scanning approach. This leads to faster measurements of the hyperfine structure for systems with high yields (more than a few thousand ions per second). Additionally, several beamline sections have been redesigned and manufactured, including a new field-ionization unit, a sharper electrostatic bend, and improved ion optics. The beamline upgrades are expected to yield an improvement of at least a factor of 5 in the signal-to-noise ratio by suppressing the non-resonant laser ions and providing time-of-flight separation between the resonant ions and the collisional background. Overall, the presented developments will further improve the selectivity, sensitivity, and efficiency of the CRIS technique.Comment: 10 pages. Under review at NIM B as part of the proceedings of EMIS 2022 at RAON, South Kore

Food systems governance e-course – SHiFT work package 5 evaluation report

The food systems approach is increasingly being used to understand the dynamics of how food is produced and consumed, with an optimal outcome for human health, social justice, economic endeavors, and the preservation of planetary resources. Since the United Nations Food Systems Summit (UNFSS) in September 2021, the food systems approach has become central to policy and practice of many international development and research organizations, multilateral organizations, and in (national) programs and policies aiming at improving food and nutrition security.Non-PRIFPRI1; 2 Promoting Healthy Diets and Nutrition for all; CRP4A4NHCGIAR Research Program on Agriculture for Nutrition and Health (A4NH

An efficient convex optimization based approach for including muscle physiology in simulating human motion

status: publishe

A convex optimization approach to dynamic musculoskeletal analysis

status: publishe