How epigenetic evolution can guide genetic evolution (abstract)

The expression level of a gene in future generations can be modified both by genetic mutations and by the attachment of methyl groups to the DNA. Since the DNA methylation pattern along a genome is inherited, methylation patterns constitute a significant epigenetic inheritance mechanism that is subject to evolution by natural selection. The variation rate of methylation patterns is generally higher than that of DNA which suggests that evolution of methylation patterns might be more rapid than that of genetic evolution. But, common consequences of methylation, such as reduced expression of methylated genes, could also be produced by genetic changes and these would have higher heritability. The question we address in this work is how the evolution of epigenetic methylation-dependent phenotypes might interact with the evolution of genetic DNA-determined phenotypes. There is no biological mechanism known to directly transfer methyl groups into equivalent DNA changes. However, in principle an indirect mechanism could cause evolved methylation patterns to enable the subsequent evolution of equivalent genetic patterns in a manner analogous to the Baldwin effect (Baldwin, Am. Nat., 30:441-451, 1896; Jablonka et al, TREE, 13:206-210, 1998). The Baldwin effect describes how non-heritable acquired characteristics can influence the evolution of equivalent genetic characteristics without any direct Lamarckian inheritance of acquired characters. This occurs because the ability to acquire or learn a new behaviour changes the selective pressures acting on genetic changes. Specifically, genetic changes that support this behaviour, e.g. by reducing learning time by making a small part of the behaviour genetically innate, may be selected for when the learning mechanism is present even though these same genetic changes may not be selected for when the learning mechanism is absent. Over generations, the modified selection pressures so produced can cause genetic assimilation of a phenotype that was previously acquired, even to the extent of making the acquisition mechanism subsequently redundant. Thus a learned behaviour can guide the evolution of an equivalent innate behaviour (Hinton & Nowlan, Complex Systems, 1: 495-502, 1987). In the Baldwin effect a rapid mechanism of lifetime adaptation guides the relatively slow genetic evolution of the same behaviour. By analogy, Jablonka et al have suggested that “genetic adaptations may be guided by heritable induced or learnt phenotypic adaptations”. Here we hypothesise that “inherited epigenetic variations may be able to ‘hold’ an adapted state for long enough to allow similar genetic variations to catch up”, as they put it, even if the epigenetic variations are not induced or learnt but simply evolved by natural selection on methylation patterns. We assume that an individual may only express one phenotype in its lifetime, but that a given genome will persist relatively unchanged on a timescale that allows its methylome to adapt by natural selection. Thus, in contrast to the Baldwin effect, in this case two mechanisms of evolution by natural selection are coupled — one acting at a different variation rate from the other. We present a simple model to illustrate how a rapidly evolving methylome can guide a slowly evolving but highly-heritable genome. This is used to show that methylome evolution can enable genetic evolution to cross fitness valleys that would otherwise require multiple genetic changes that were each selected against. This finding suggests that the relatively rapid evolution of methylation patterns can produce novel phenotypes that are subsequently genetically assimilated in DNA evolution without direct transfer or appeal to induced phenotypes. This can enable the genetic evolution of new phenotypes that would not be found by genetic evolution alone, even if methylation is not significant in the ultimate phenotype

Electromagnetic mirror drive system

Oscillatory electromagnetic mirror drive system for horizon scanner

Flavor independent systematics of excited baryons and intra-band transition

Transitions among excited nucleons are studied within a non-relativistic quark model with a deformed harmonic oscillator potential. The transition amplitudes are factorized into the $l$-th moment and a geometrical factor. This fact leads to an analogous result to the ``Alaga-rule'' for baryons.Comment: 4 Pages, 2 figures, Talk given at XVI International Conference on Particles and Nuclei (PaNic02), Osaka, Japan, Sep.30 - Oct.4, 200

On the D0D^0 -- DsD_s lifetime difference and τ→7π+ντ\tau\to 7\pi + \nu_\tau decays

In this paper we discuss some aspects of inclusive decays of charmed mesons and also decays of the $\tau$ lepton into $\nu_\tau + 7\pi$. We find that phase space effects are likely to explain the observed lifetime ratio $\tau(D_s^+) / \tau(D^0)$ = 1.17. In particular one need not appeal to a large annihilation contribution in the inclusive $D^0$ decay which, being absent in $D_s^+$ decays could also contribute to the enhanced $D^0$ decay rate relative to that of the $D_s^+$. Examining a separate problem, we find that the rate for $\tau\to \nu_\tau + 7\pi$ is almost completely dominated by the tiny phase space for the final eight particle state. Using an effective chiral Lagrangian to estimate the matrix element yields a branching ratio into the channel of interest far smaller than the present upper bound.Comment: No figure

A Pedestrian Introduction to Gamow Vectors

The Gamow vector description of resonances is compared with the S-matrix and the Green function descriptions using the example of the square barrier potential. By imposing different boundary conditions on the time independent Schrodinger equation, we obtain either eigenvectors corresponding to real eigenvalues and the physical spectrum or eigenvectors corresponding to complex eigenvalues (Gamow vectors) and the resonance spectrum. We show that the poles of the S matrix are the same as the poles of the Green function and are the complex eigenvalues of the Schrodinger equation subject to a purely outgoing boundary condition. The intrinsic time asymmetry of the purely outgoing boundary condition is discussed. Finally, we show that the probability of detecting the decay within a shell around the origin of the decaying state follows an exponential law if the Gamow vector (resonance) contribution to this probability is the only contribution that is taken into account.Comment: 25 RevTex pages, 3 figure

Intrinsic Charm Flavor and Helicity Content in the Proton

Contributions to the quark flavor and spin observables from the intrinsic charm in the proton are discussed in the SU(4) quark meson fluctuation model. Our results suggest that the probability of finding the intrinsic charm in the proton is less than 1%. The intrinsic charm helicity is small and negative, $\Delta c \simeq -(0.003\sim 0.015)$. The fraction of the total quark helicity carried by the intrinsic charm is less than 2%, and c_\up/c_\dw=35/67.Comment: 4 pages, 2 tables (revised version

Chern-Simons-fermion model of quarks

We propose an extension of the standard model where quarks are viewed as fermions with a ``bare'' integer (weak) hypercharge which is normalized with a fractional part created by a quantized topological Chern-Simons configuration of the weak gauge fields. Consistency with hypercharge patterns not included in the standard model is shown.Comment: 4 pages, Revtex, no figure

Improved limits on photon velocity oscillations

The mixing of the photon with a hypothetical sterile paraphotonic state would have consequences on the cosmological propagation of photons. The absence of distortions in the optical spectrum of distant Type Ia supernov\ae allows to extend by two orders of magnitude the previous limit on the Lorentz-violating parameter $\delta$ associated to the photon-paraphoton transition, extracted from the abscence of distortions in the spectrum of the cosmic microwave background. The new limit is consistent with the interpretation of the dimming of distant Type Ia supernov\ae as a consequence of a nonzero cosmological constant. Observations of gamma-rays from active galactic nuclei allow to further extend the limit on $\delta$ by ten orders of magnitude.Comment: 10 pages, 4 Postscript figures, use epsfig, amssym

Improved predictions of the standard model and the detection of new physics in neutron beta decay

We improve the current predictions of the standard model for neutron beta decay observables and compare them with the currently available ones. Next we study their implications in the possible detection of new physics. We discuss where the limitations are and where further efforts should be directed.Comment: 8 pages, 3 figures, to appear in Physics Letters