Solid Surface Structure Affects Liquid Order at the Polystyrene/SAM Interface

We present a combined x-ray and neutron reflectivity study characterizing the interface between polystyrene (PS) and silanized surfaces. Motivated by the large difference in slip velocity of PS on top of dodecyl-trichlorosilane (DTS) and octadecyl-trichlorosilane (OTS) found in previous studies, these two systems were chosen for the present investigation. The results reveal the molecular conformation of PS on silanized silicon. Differences in the molecular tilt of OTS and DTS are replicated by the adjacent phenyl rings of the PS. We discuss our findings in terms of a potential link between the microscopic interfacial structure and dynamic properties of polymeric liquids at interfaces

Scalable Katz ranking computation in large static and dynamic graphs

Network analysis defines a number of centrality measures to identify the most central nodes in a network. Fast computation of those measures is a major challenge in algorithmic network analysis. Aside from closeness and betweenness, Katz centrality is one of the established centrality measures. In this paper, we consider the problem of computing rankings for Katz centrality. In particular, we propose upper and lower bounds on the Katz score of a given node. While previous approaches relied on numerical approximation or heuristics to compute Katz centrality rankings, we construct an algorithm that iteratively improves those upper and lower bounds until a correct Katz ranking is obtained. We extend our algorithm to dynamic graphs while maintaining its correctness guarantees. Experiments demonstrate that our static graph algorithm outperforms both numerical approaches and heuristics with speedups between 1.5× and 3.5×, depending on the desired quality guarantees. Our dynamic graph algorithm improves upon the static algorithm for update batches of less than 10000 edges. We provide efficient parallel CPU and GPU implementations of our algorithms that enable near real-time Katz centrality computation for graphs with hundreds of millions of nodes in fractions of seconds

Waterkwaliteit zonder toxiciteit

Schoon oppervlaktewater zonder microverontreinigingen – wie wil dat niet? Maar we gebruiken meer dan 100.000 chemische stoffen! Maatregelen zijn nodig, maar welke? Wat heb je aan kennis over individuele stoffen? En hoe onderzoek je mengsels? Met de Ecologische Sleutelfactor Toxiciteit (ESF-Toxiciteit) wordt het mogelijk om heel precies de stoffen en de plekken met de grootste risico’s te identificeren

Waterkwaliteit zonder toxiciteit

Schoon oppervlaktewater zonder microverontreinigingen – wie wil dat niet? Maar we gebruiken meer dan 100.000 chemische stoffen! Maatregelen zijn nodig, maar welke? Hoe ver kom je door individuele stoffen te onderzoeken? En hoe kijk je naar realistische mengsels? Sinds kort is er de Ecologische Sleutelfactor Toxiciteit (ESF-Toxiciteit). Hiermee wordt het mogelijk om te werken aan de verbetering van de waterkwaliteit door heel precies de stoffen en de plekken met de grootste risico’s te identificeren

Optimizing the Timing of Highest Hydrocortisone Dose in Children and Adolescents With 21-Hydroxylase Deficiency

CONTEXT: Hydrocortisone treatment of young patients with 21-hydroxylase deficiency (21OHD) is given thrice daily, but there is debate about the optimal timing of the highest hydrocortisone dose, either mimicking the physiological diurnal rhythm (morning), or optimally suppressing androgen activity (evening). OBJECTIVE: We aimed to compare 2 standard hydrocortisone timing strategies, either highest dosage in the morning or evening, with respect to hormonal status throughout the day, nocturnal blood pressure (BP), and sleep and activity scores. METHODS: This 6-week crossover study included 39 patients (aged 4-19 years) with 21OHD. Patients were treated for 3 weeks with the highest hydrocortisone dose in the morning, followed by 3 weeks with the highest dose in the evening (n = 21), or vice versa (n = 18). Androstenedione (A4) and 17-hydroxyprogesterone (17OHP) levels were quantified in saliva collected at 5 am; 7 am; 3 pm; and 11 pm during the last 2 days of each treatment period. The main outcome measure was comparison of saliva 17OHP and A4 levels between the 2 treatment strategies. RESULTS: Administration of the highest dose in the evening resulted in significantly lower 17OHP levels at 5 am, whereas the highest dose in the morning resulted in significantly lower 17OHP and A4 levels in the afternoon. The 2 treatment dose regimens were comparable with respect to averaged daily hormone levels, nocturnal BP, and activity and sleep scores. CONCLUSION: No clear benefit for either treatment schedule was established. Given the variation in individual responses, we recommend individually optimizing dose distribution and monitoring disease control at multiple time points