10 research outputs found
Vom proletarischen Prometheus zur Mutter Heimat â Entwicklungslinien des Sowjetmythos
GĂŒnther H. Vom proletarischen Prometheus zur Mutter Heimat â Entwicklungslinien des Sowjetmythos. In: Grimminger R, ed. Mythos im Text. Zur Literatur des 20. Jahrhunderts. Bielefelder Schriften zu Linguistik und Literaturwissenschaft. Vol 10. Bielefeld: Aisthesis-Verl.; 1998: 107-116
Befreite Worte und Sternensprache. Der italienische und der russische Futurismus
GĂŒnther H. Befreite Worte und Sternensprache. Der italienische und der russische Futurismus. In: Grimminger R, ed. Literarische Moderne. rowohlts enzyklopĂ€die. Vol 553. Reinbek bei Hamburg: Rowohlt; 1995: 284-313
Guy Debord und die Situationistische Internationale
Gilcher-Holtey I. Guy Debord und die Situationistische Internationale. In: Grimminger R, ed. Kunst-Macht-Gewalt. Der Ă€sthetische Ort der AggressivitĂ€t. MĂŒnchen: Fink; 2000: 87-104
Georg Simmel e l'estetica. Arte, conoscenza e vita moderna
Cosa si cela dietro la questione estetica nellâopera del filosofo e sociologo Georg Simmel? La sua flĂąnerie intellettuale, il suo cosiddetto approccio estetico, hanno rappresentato davvero un ostacolo allo sviluppo di una solida metodologia scientifica in ambito sociologico? O non puĂČ piuttosto, il suo modo di procedere, essere messo in relazione con alcune delle piĂč recenti teorie epistemologiche, e se sĂŹ, in che misura? Lâelemento che accomuna lâinsieme dei contributi raccolti nel presente volume, Ăš rappresentato dallo sforzo di offrire uno sguardo nuovo su alcuni degli aspetti piĂč problematici della produzione filosofica e sociologica di questo protagonista del Novecento
Political strata and the flows of history: Hans Freyerâs conservatism in light of its metaphors
Thrombin Has Biphasic Effects on the Nitric Oxide-cGMP Pathway in Endothelial Cells and Contributes to Experimental Pulmonary Hypertension
Dissecting the genetic heterogeneity of gastric cancer
Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture. Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO. Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level. Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO. Errata: Hess, T., Maj, C., Gehlen, J. et. al. Corrigendum to âDissecting the genetic heterogeneity of gastric cancerâ. eBioMedicine. 2023:94:104709. DOI: 10.1016/j.ebiom.2023.104709</p