28 research outputs found

    Introduction: Special Issue on Brazil and the Global South

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    El Dialogo de Violencias en el Brasil Dictatorial

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    [ES]Este artículo presenta una lectura preliminar de los panfletos políticos brasileños y latinoamericanos en general, preservados en el sector de las Colecciones Especiales de la Biblioteca Senate House, de la Universidad de Londres, Reino Unido. Los temas que abarca van desde publicaciones de sindicatos y organizaciones de derechos humanos hasta declaraciones de diversas iglesias y material relacionado con aspectos económicos y políticos. Esta colaboración tiene como objetivo difundir la existencia de los documentos y de su uso potencial en cuanto representan una narrativa alternativa a los discursos dominantes sobre la dictadura brasileña de 1964. Usando el tema de la violencia, tanto estructural como física, este artículo presenta una nueva perspectiva sobre cómo interpretar las ideologías que aparecen en esos discursos

    The Dialogue of Violences in Dictatorial Brazil

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    This article presents a preliminary reading of the political pamphlets, from Brazil, and Latin America in general, that are preserved in the Special Collections department at Senate House Library of the University of London. The source of the themes discussed range from publications of worker unions and human rights organizations, to various church declarations, and other material with economic and political aspects. This collaboration aims to propagate these documents and their potential as alternative narratives to dominant discourses regarding the Brazilian dictatorship of 1964-85. By using the theme of violence, both structural and physical, as a framework, this article poses a new perspective on how to interpret the ideologies that appear in those discourses.Este artigo apresenta uma leitura preliminar dos panfletos políticos, do Brasil e da América Latina em geral, que são preservados no departamento de coleções especiais na Biblioteca Senate House da Universidade de Londres, Grã Bretanha. Os tópicos abordados vão desde publicações de sindicatos e de organizações de Direitos Humanos, até declarações de diversas igrejas e materiais relacionados a aspectos econômicos e políticos. Esta colaboração visa compartilhar estes documentos e seu potencial como narrativas alternativas para discursos dominantes sobre a ditadura brasileira de 1964. Ao usar o tema da violência, tanto estrutural como física, como um panorama, o presente artigo apresenta uma nova perspectiva sobre como interpretar as ideologias que aparecem nesses discursos.Este artículo presenta una lectura preliminar de los panfletos políticos brasileños y latinoamericanos en general, preservados en el sector de las Colecciones Especiales de la Biblioteca Senate House, de la Universidad de Londres, Reino Unido. Los temas que abarca van desde publicaciones de sindicatos y organizaciones de derechos humanos hasta declaraciones de diversas iglesias y material relacionado con aspectos económicos y políticos. Esta colaboración tiene como objetivo difundir la existencia de los documentos y de su uso potencial en cuanto representan una narrativa alternativa a los discursos dominantes sobre la dictadura brasileña de 1964. Usando el tema de la violencia, tanto estructural como física, este artículo presenta una nueva perspectiva sobre cómo interpretar las ideologías que aparecen en esos discursos

    Para una comisión viviente : observaciones de la comision nacional de la verdad en Brasil

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    Resumen: Desde los años setenta, las transiciones a la democracia han estado acompañadas por una herramienta de reconciliación particular: las comisiones de la verdad. Este mecanismo es una respuesta a la noción de un “derecho a la verdad”, tal como está descrito en la ley internacional, y ahora se considera un paso completamente normal en el camino a la democracia. Sin embargo, la opinión de esta autora es que el modelo tradicional de las comisiones de la verdad ya no es útil para la generación de hoy a la hora de alcanzar sus objetivos. Utilizando el ejemplo de la reciente comisión de la verdad Brasileña, vamos a ver cómo y por qué tenemos que reconsiderar nuestro concepto y esperanzas sobre las comisiones de la verdad. Palabras clave: justicia transicional, Comisión de la Verdad, Brasil Abstract: Since the seventies, transitions to democracy have been accompanied by a particular tool of reconciliation: truth commissions. Such a mechanism is the response to the notion of a “right to truth” as described in international law, and is now considered a completely normal step on the path to democratization. However, it is this author's opinion that the traditional model for truth commissions is no longer useful for today's generations in achieving any of its aims. Using the example of Brazil's recent truth commission, I will look at how and why we need to reconsider our concept and expectations of truth commissions

    Association of Upfront Peptide Receptor Radionuclide Therapy With Progression-Free Survival Among Patients With Enteropancreatic Neuroendocrine Tumors

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    open57noIMPORTANCE Data about the optimal timing for the initiation of peptide receptor radionuclide therapy (PRRT) for advanced, well-differentiated enteropancreatic neuroendocrine tumors are lacking. OBJECTIVE To evaluate the association of upfront PRRT vs upfront chemotherapy or targeted therapy with progression-free survival (PFS) among patients with advanced enteropancreatic neuroendocrine tumors who experienced disease progression after treatment with somatostatin analogues (SSAs). DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study analyzed the clinical records from 25 Italian oncology centers for patients aged 18 years or older who had unresectable, locally advanced or metastatic, well-differentiated, grades 1 to 3 enteropancreatic neuroendocrine tumors and received either PRRT or chemotherapy or targeted therapy after experiencing disease progression after treatment with SSAs between January 24, 2000, and July 1, 2020. Propensity score matching was done to minimize the selection bias. EXPOSURES Upfront PRRT or upfront chemotherapy or targeted therapy. MAIN OUTCOMES AND MEASURES The main outcome was the difference in PFS among patients who received upfront PRRT vs among those who received upfront chemotherapy or targeted therapy. A secondary outcome was the difference in overall survival between these groups. Hazard ratios (HRs) were fitted in a multivariable Cox proportional hazards regression model to adjust for relevant factors associated with PFS and were corrected for interaction with these factors. RESULTS Of 508 evaluated patients (mean ([SD] age, 55.7 [0.5] years; 278 [54.7%] were male), 329 (64.8%) received upfront PRRT and 179 (35.2%) received upfront chemotherapy or targeted therapy. The matched group included 222 patients (124 [55.9%] male; mean [SD] age, 56.1 [0.8] years), with 111 in each treatment group. Median PFS was longer in the PRRT group than in the chemotherapy or targeted therapy group in the unmatched (2.5 years [95%CI, 2.3-3.0 years] vs 0.7 years [95%CI, 0.5-1.0 years]; HR, 0.35 [95%CI, 0.28-0.44; P < .001]) and matched (2.2 years [95% CI, 1.8-2.8 years] vs 0.6 years [95%CI, 0.4-1.0 years]; HR, 0.37 [95%CI, 0.27-0.51; P < .001]) populations. No significant differences were shown in median overall survival between the PRRT and chemotherapy or targeted therapy groups in the unmatched (12.0 years [95%CI, 10.7-14.1 years] vs 11.6 years [95%CI, 9.1-13.4 years]; HR, 0.81 [95%CI, 0.62-1.06; P = .11]) and matched (12.2 years [95% CI, 9.1-14.2 years] vs 11.5 years [95%CI, 9.2-17.9 years]; HR, 0.83 [95%CI, 0.56-1.24; P = .36]) populations. The use of upfront PRRT was independently associated with improved PFS (HR, 0.37; 95%CI, 0.26-0.51; P < .001) in multivariable analysis. After adjustment of values for interaction, upfront PRRT was associated with longer PFS regardless of tumor functional status (functioning: adjusted HR [aHR], 0.39 [95%CI, 0.27-0.57]; nonfunctioning: aHR, 0.29 [95%CI, 0.16-0.56]), grade of 1 to 2 (grade 1: aHR, 0.21 [95%CI, 0.12-0.34]; grade 2: aHR, 0.52 [95%CI, 0.29-0.73]), and site of tumor origin (pancreatic: aHR, 0.41 [95%CI, 0.24-0.61]; intestinal: aHR, 0.19 [95%CI, 0.11-0.43]) (P < .001 for all). Conversely, the advantage was not retained in grade 3 tumors (aHR, 0.31; 95%CI, 0.12-1.37; P = .13) or in tumors with a Ki-67 proliferation index greater than 10% (aHR, 0.73; 95%CI, 0.29-1.43; P = .31). CONCLUSIONS AND RELEVANCE In this cohort study, treatment with upfront PRRT in patients with enteropancreatic neuroendocrine tumors who had experienced disease progression with SSA treatment was associated with significantly improved survival outcomes compared with upfront chemotherapy or targeted therapy. Further research is needed to investigate the correct strategy, timing, and optimal specific sequence of these therapeutic options.openPusceddu, Sara; Prinzi, Natalie; Tafuto, Salvatore; Ibrahim, Toni; Filice, Angelina; Brizzi, Maria Pia; Panzuto, Francesco; Baldari, Sergio; Grana, Chiara M.; Campana, Davide; Davì, Maria Vittoria; Giuffrida, Dario; Zatelli, Maria Chiara; Partelli, Stefano; Razzore, Paola; Marconcini, Riccardo; Massironi, Sara; Gelsomino, Fabio; Faggiano, Antongiulio; Giannetta, Elisa; Bajetta, Emilio; Grimaldi, Franco; Cives, Mauro; Cirillo, Fernando; Perfetti, Vittorio; Corti, Francesca; Ricci, Claudio; Giacomelli, Luca; Porcu, Luca; Di Maio, Massimo; Seregni, Ettore; Maccauro, Marco; Lastoria, Secondo; Bongiovanni, Alberto; Versari, Annibale; Persano, Irene; Rinzivillo, Maria; Pignata, Salvatore Antonio; Rocca, Paola Anna; Lamberti, Giuseppe; Cingarlini, Sara; Puliafito, Ivana; Ambrosio, Maria Rosaria; Zanata, Isabella; Bracigliano, Alessandra; Severi, Stefano; Spada, Francesca; Andreasi, Valentina; Modica, Roberta; Scalorbi, Federica; Milione, Massimo; Sabella, Giovanna; Coppa, Jorgelina; Casadei, Riccardo; Di Bartolomeo, Maria; Falconi, Massimo; de Braud, FilippoPusceddu, Sara; Prinzi, Natalie; Tafuto, Salvatore; Ibrahim, Toni; Filice, Angelina; Brizzi, Maria Pia; Panzuto, Francesco; Baldari, Sergio; Grana, Chiara M.; Campana, Davide; Davì, Maria Vittoria; Giuffrida, Dario; Zatelli, Maria Chiara; Partelli, Stefano; Razzore, Paola; Marconcini, Riccardo; Massironi, Sara; Gelsomino, Fabio; Faggiano, Antongiulio; Giannetta, Elisa; Bajetta, Emilio; Grimaldi, Franco; Cives, Mauro; Cirillo, Fernando; Perfetti, Vittorio; Corti, Francesca; Ricci, Claudio; Giacomelli, Luca; Porcu, Luca; Di Maio, Massimo; Seregni, Ettore; Maccauro, Marco; Lastoria, Secondo; Bongiovanni, Alberto; Versari, Annibale; Persano, Irene; Rinzivillo, Maria; Pignata, Salvatore Antonio; Rocca, Paola Anna; Lamberti, Giuseppe; Cingarlini, Sara; Puliafito, Ivana; Ambrosio, Maria Rosaria; Zanata, Isabella; Bracigliano, Alessandra; Severi, Stefano; Spada, Francesca; Andreasi, Valentina; Modica, Roberta; Scalorbi, Federica; Milione, Massimo; Sabella, Giovanna; Coppa, Jorgelina; Casadei, Riccardo; Di Bartolomeo, Maria; Falconi, Massimo; de Braud, Filipp

    Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

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