Development of a Combined Quanity and Quality Model for Optimal Groundwater Management

Presented is a procedure for incorporating solute transport as linear constraints within computer models for optimizing regional groundwater extraction strategies. The MODCON modelling procedure uses linear goal programming, embedded linearized equations for flow and solute transport and a MOC simulation model. Assumed is 2D flow and solute transport and a dispersed conservative contaminant. The MODCON procedure develops steady groundwater extraction strategies that will satisfy future groundwater quality constraints while simultaneously causing future piezometric heads to be as close to current heads as possible. The procedure is applied to a 160 square mile area in southeastern Arkansas

Capacitor-type micrometeoroid detectors

The metal oxide semiconductor (MOS) capacitor micrometeroid detector consists of a thin dielectric capacitor fabricated on a silicon wafer. In operation, the device is charged to a voltage level sufficiently near breakdown that micrometeoroid impacts will cause dielectric deformation or heating and subsequent arc-over at the point of impact. Each detector is capable of recording multiple impacts because of the self-healing characteristics of the device. Support instrumentation requirements consist of a voltage source and pulse counters that monitor the pulse of recharging current following every impact. An investigation has been conducted in which 0.5 to 5 micron diameter carbonized iron spheres traveling at velocities of 4 to 10 Km/sec were impacted on to detectors with either a dielectric thickness of 0.4 or 1.0 micron. This study demonstrated that an ion microprobe tuned to sufficiently high resolution can detect Fe remaining on the detector after the impact. Furthermore, it is also possible to resolve Fe ion images free of mass interferences from Si, for example, giving its spatial distribution after impact. Specifically this technique has shown that significant amounts of impacting particles remain in the crater and near it which can be analyzed for isotopic content. Further testing and calibration could lead to quantitive analysis. This study has shown that the capacitor type micrometeroid detector is capable of not only time and flux measurements but can also be used for isotopic analysis

Disposal of Household Wastewater in Soils of High Stone Content (1981-1983)

Four experimental filter fields were constructed with built-in monitoring equipment in Nixa soils. These soils contain many chert fragments and a fragipan about 60 cm below the soil surface. The fragipan restricts downward movement of water and is the designlimitingfeature. The four filter fields were: 1. A standard filter field, 76 cm deep. The bottom of the trench was in the fragipan. 2. A modified standard filter field, 30 cm deep. The bottom of the trench was above the fragipan. 3. A modified pressure filter field, 40 cm deep. The bottom of the trench was above the fragipan. In addition, a pressure-distribution system was used to insure uniform distribution of effluent in the trench. Inadvertently, this field was installed in a different soil, and the results cannot be compared directly with the other three. 4. Another modified pressure filter field with the bottom of the trench only 6 cm below the soil surface. Observation of these systems confirms that placing filter fields higher in the soil above the hydraulically limiting horizon results in improved hydraulic performance. The presence of the fragipan amplified the adverse effects attributable to climatic stress. The seepage beds which are higher in the soil profile are able to handle the effluent load and climate load with less danger of surfacing

Development of a combined quantity and quality model for optimal unsteady groundwater management

Presented is a procedure for incorporating solute transport as linear constraints within computer models for optimizing regional groundwater extraction strategies. The MODCON modelling procedure uses linear goal programming, embedded linearized equations for flow and solute transport and a MOC simulation model. Assumed is 20 flow and solute transport and a dispersed conservative contaminant. The MODCON procedure develops steady groundwater extraction strategies that will satisfy future groundwater quality constraints while simultaneously causing future piezometric heads to be as close to current heads as possible. The procedure is applied to a 160 square mile area in southeastern Arkansas

Development of linear water quality constraints for optimal groundwater management

Proposed is a procedure for incorporating solute transport as linear constraints within computer models for optimizing regional groundwater extraction strategies. . MODCON procedure uses linear goal programming. embedded linearized equations for flow and solute transport. and MOC simulation model. Assumed is 20 flow and solute transport. and a dispersed conservative contaminant

Acute Opioid Withdrawal Mimicking Postoperative Joint Infection Following anterior cruciate ligament (ACL) Reconstruction: A Case Report.

BACKGROUND A short course of opioid narcotics is often prescribed for postoperative anterior cruciate ligament (ACL) reconstruction pain management. Unfortunately, there is a well-documented incidence of opioid withdrawal syndrome (OWS) following short-term use of these medications. OWS can present with symptoms such as influenza-like illness. It is important to differentiate OWS from infectious illnesses, especially after surgery. CASE REPORT We present a case of OWS in a patient who underwent ACL reconstruction 7 days prior. The patient\u27s OWS symptoms were similar to symptoms of a postoperative infection. The knee was aspirated, and the analysis of the aspirate was not concerning for an infection. The patient\u27s symptoms spontaneously resolved on postoperative day 10. This is the first documented case of OWS mimicking ACL reconstruction joint infection. CONCLUSIONS OWS after surgery may present with symptoms similar to joint infection. It is important to consider OWS as a potential complication after surgery and differentiate it from infection to avoid any further unnecessary invasive treatments for the patient

Galaxy-scale Bars in Late-type Sloan Digital Sky Survey Galaxies Do Not Influence the Average Accretion Rates of Supermassive Black Holes

Galaxy-scale bars are expected to provide an effective means for driving material toward the central region in spiral galaxies, and possibly feeding supermassive black holes (BHs). Here we present a statistically complete study of the effect of bars on average BH accretion. From a well-selected sample of 50,794 spiral galaxies (with {M}_{* }\sim 0.2\mbox{--}30\times {10}^{10}\,{M}_{\odot }) extracted from the Sloan Digital Sky Survey Galaxy Zoo 2 project, we separate those sources considered to contain galaxy-scale bars from those that do not. Using archival data taken by the Chandra X-ray Observatory, we identify X-ray luminous (${L}_{{\rm{X}}}\gtrsim {10}^{41}\,\mathrm{erg}\,{{\rm{s}}}^{-1}$) active galactic nuclei and perform an X-ray stacking analysis on the remaining X-ray undetected sources. Through X-ray stacking, we derive a time-averaged look at accretion for galaxies at fixed stellar mass and star-formation rate, finding that the average nuclear accretion rates of galaxies with bar structures are fully consistent with those lacking bars (${\dot{M}}_{\mathrm{acc}}\approx 3\times {10}^{-5}$ ${M}_{\odot }$ yr−1). Hence, we robustly conclude that large-scale bars have little or no effect on the average growth of BHs in nearby ($z\lt 0.15$) galaxies over gigayear timescales

Introducing information retrieval for biomedical informatics students

Introducing biomedical informatics (BMI) students to natural language processing (NLP) requires balancing technical depth with practical know-how to address application-focused needs. We developed a set of three activities introducing introductory BMI students to information retrieval with NLP, covering document representation strategies and language models from TF-IDF to BERT. These activities provide students with hands-on experience targeted towards common use cases, and introduce fundamental components of NLP workflows for a wide variety of applications

Mechanoaccumulative elements of the mammalian actin cytoskeleton

To change shape, divide, form junctions, and migrate, cells reorganize their cytoskeletons in response to changing mechanical environments [1-4]. Actin cytoskeletal elements, including myosin II motors and actin crosslinkers, structurally remodel and activate signaling pathways in response to imposed stresses [5-9]. Recent studies demonstrate the importance of force-dependent structural rearrangement of α-catenin in adherens junctions [10] and vinculin's molecular clutch mechanism in focal adhesions [11]. However, the complete landscape of cytoskeletal mechanoresponsive proteins and the mechanisms by which these elements sense and respond to force remain to be elucidated. To find mechanosensitive elements in mammalian cells, we examined protein relocalization in response to controlled external stresses applied to individual cells. Here, we show that non-muscle myosin II, α-actinin, and filamin accumulate to mechanically stressed regions in cells from diverse lineages. Using reaction-diffusion models for force-sensitive binding, we successfully predicted which mammalian α-actinin and filamin paralogs would be mechanoaccumulative. Furthermore, a Goldilocks zone must exist for each protein where the actin-binding affinity must be optimal for accumulation. In addition, we leveraged genetic mutants to gain a molecular understanding of the mechanisms of α-actinin and filamin catch-bonding behavior. Two distinct modes of mechanoaccumulation can be observed: a fast, diffusion-based accumulation and a slower, myosin II-dependent cortical flow phase that acts on proteins with specific binding lifetimes. Finally, we uncovered cell-type and cell-cycle-stage-specific control of the mechanosensation of myosin IIB, but not myosin IIA or IIC. Overall, these mechanoaccumulative mechanisms drive the cell's response to physical perturbation during proper tissue development and disease

Preparing for and managing change: Climate adaptation for biodiversity and ecosystems

The emerging field of climate-change adaptation has experienced a dramatic increase in attention as the impacts of climate change on biodiversity and ecosystems have become more evident. Preparing for and addressing these changes are now prominent themes in conservation and natural resource policy and practice. Adaptation increasingly is viewed as a way of managing change, rather than just maintaining existing conditions. There is also increasing recognition of the need not only to adjust management strategies in light of climate shifts, but to reassess and, as needed, modify underlying conservation goals. Major advances in the development of climate-adaptation principles, strategies, and planning processes have occurred over the past few years, although implementation of adaptation plans continues to lag. With ecosystems expected to undergo continuing climate-mediated changes for years to come, adaptation can best be thought of as an ongoing process, rather than as a fixed endpoint. © The Ecological Society of America