Italian for speakers of Spanish

Through the creation of Doodly videos, this project will draw the attention of speakers of Spanish to both the commonalities and where the languages diverge to speed up their comprehension and assimilation of Italian. Making these videos available to students will attract those who are looking to study a new language, namely Italian, after several years of studying Spanish.Accepted manuscrip

Anaerobic digestion of organic wastes: the impact of operating conditions on hydrolysis efficiency and microbial community composition

2012 Summer.Includes bibliographical references.Anaerobic digestion (AD) is an environmentally sustainable technology to manage organic waste (e.g., food, yard, agricultural, industrial wastes). Economic profitability, however, remains a key barrier to widespread implementation of AD for the conversion of specific feedstocks (e.g., manure, the organic fraction of municipal solid waste (OFMSW), and agricultural residue) to energy. Specifically, high capital and operating costs and reactor instability have continually deterred the use of AD. In order to develop AD systems that are highly efficient and more cost-effective, it is necessary to optimize the microbial activity that mediates the digestion process. Multi-stage AD systems are promising technologies because they allow for separate process optimization of each stage and can enable processing of high-solids content waste. Leachate is recycled through the system, which reduces heating and pumping costs, as well as conserving water. The leachate recycle, however, leads to an increase in ammonia and salinity concentrations. At this time, the impact of reactor conditions (ammonia and salinity concentrations) on hydrolysis is not well understood. As hydrolysis is one rate-limiting step of the process in the conversion of refractory wastes (e.g., lignocellulosic materials), optimization of hydrolysis has the potential to radically improve the economic profitability of AD. The specific objectives of this research were to: 1) determine the effects of operating conditions on hydrolysis efficiency for a variety of solid wastes (manure, food waste, and agricultural residue); 2) determine hydrolysis kinetic parameters as a function of the operating conditions; and 3) identify characteristics of microbial communities that perform well under elevated ammonia and salinity concentrations. To this end, small-scale batch reactors were used to determine hydrolysis efficiency and kinetic rates. Initially, the AD sludge inoculum was exposed directly to the high ammonia and salinity concentrations (1, 2.5, 5 g Total Ammonia Nitrogen (TAN)/L and 3.9, 7.9, 11.8 g sodium/L) as would occur in a reactor treating organic waste with leachate recycle. Results demonstrated a need to acclimate, or adapt, the microorganisms to high concentrations, as methane generation was significantly inhibited with high concentrations. Thus, the organisms were acclimated for two to four months to these testing conditions. The batch studies were repeated, and results demonstrated substantial improvement in hydrolysis efficiency and methane generation. However, although differences in kinetic rates were not statistically significant, general trends in hydrolysis rates suggested that hydrolysis efficiency decreases with increased ammonia and salinity concentrations for a variety of feedstocks (i.e., manure, food waste, agricultural residue). Additionally, results demonstrated that acclimation was necessary to achieve optimal hydrolysis rates. Furthermore, microbial community composition changes in the inocula post-acclimation indicated that reactor inoculation could help improve tolerance to elevated levels of ammonia and salinity to minimize reactor start-up times and improve economic viability

Exploring Mars Mysteries in NASA Photographs: Could Some Images be Animal Skeletons?

The NASA photographs containing what appear to be animal skeletons have created a mystery that remains unsolved today. Because they generate questions and inquiries in many arenas, the animal skeleton pictures were used to help gifted students critically think about how these structures were created. Several additional exceptionalities common in most groups of students, including attention deficit disorder with and without hyperactivity and difficulties in executive functioning, were addressed through the lesson design. The exceptionalities were addressed through methods that could be used in any classroom while using the Mars Animal Skeletons to motivate and engage students. Incorporation of teaching strategies to accommodate these exceptionalities allows delivery of an engaging lesson that meets the needs of all learners

Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes

AbstractHuman papillomavirus (HPV) infection is severely limited in its natural host, primary human keratinocytes. Our data show HPV infectivity in primary keratinocytes is over 100- and 1,000-fold lower than in established keratinocyte cell lines NIKS and HaCaT, respectively. Here, we show that the basal level of autophagy in primary human foreskin keratinocytes (HFKs) is higher than in immortalized keratinocytes, and that HPV16 virions significantly induce autophagy in HFKs. Interestingly, HPV16 infectivity is dramatically enhanced by knockdown of essential autophagy genes as well as biochemical inhibition of autophagy. The increase in HPV16 infectivity by autophagy inhibition is most significant in HFKs, showing an inverse correlation with basal HPV16 infectivity in HFK, NIKS, HaCaT, and 293FT cells. Further, inhibition of autophagy delays degradation of HPV16 capsid proteins during virus trafficking, indicating that host autophagy induced by HPV16 virions inhibits infection of primary keratinocytes through rapid degradation of viral capsid proteins

What is the appropriate diagnostic evaluation of fibroids?

Although transvaginal sonography (TVS) has inconsistent sensitivity (0.21-1.00) and specificity (0.53-1.00), its cost-efficiency and noninvasiveness make it the best initial test for ruling in fibroid disease (strength of recommendation [SOR]: B, based on expert opinion, a systematic review, and prospective studies). Sonohysterography (SHG) and hysteroscopy have superior sensitivity, specificity, and more discriminating positive and negative likelihood ratios for diagnosing fibroids than does TVS (SOR: B, systematic review). SHG is less painful, less invasive, and more cost-effective than hysteroscopy (SOR: B; single, prospective comparative study and cost comparison). Magnetic resonance imaging (MRI) had comparable precision to TVS in a single study, but it is too expensive to be a good initial test for fibroids (SOR: C, expert opinion and an uncontrolled prospective study). One study reported a strong correlation between ultrasound and bimanual examination (SOR: C, retrospective case review)

McGurk Doesn\u27t Work: Using EEG to Investigate the Time Course of the McGurk Effect

Speech perception is an inherently multimodal process, where auditory signals provide concurrent information to visual information from the speaker\u27s mouth movements. The McGurk effect is an illusion often used to study audiovisual speech integration; it is created by presenting incongruent auditory and visual speech cues. In the original study, listening to the spoken syllable /ba/ while watching visual mouth movements for /ga/ resulted in a \u27fusion\u27 perception of /da/ in 98% of participants (McGurk & MacDonald, 1976). Following, research on audiovisual integration has largely looked at the effect in isolated syllables. Our goal was to enhance the ecological validity of the McGurk effect by creating word stimuli mimicking everyday conversations (e.g., pairing audio for /beer/ with lip movements for /gear/ to determine listeners\u27 interpretation). In this study, we varied task (forced-choice vs. open-ended) and stimuli (words vs. non-words) between participants. In the word condition, all three stimuli formed words (e.g., beer, deer, gear) whereas in the non-word condition, either the B, D, or G stimuli was a word and the other two were nonwords (e.g., besk, desk, gesk). We found that fusion responses were much lower than in previous studies, potentially due to the use of full words. Importantly, participants also showed the most fusion responses when the D choice was a word with B and G forming non-words. We conclude that the McGurk effect occurs at a decision level rather than a perceptual level because task and stimulus differences influenced McGurk effect likelihood

A Pilot Study of Value of Information Analysis to Support Research Recommendations for the National Institute for Health and Clinical Excellence

Background - This project developed as a result of the activities of the Research Teams at the Centre for Health Economics, University of York, and ScHARR at the University of Sheffield in the methods and application of decision analysis and value of information analysis as a means of informing the research recommendations made by NICE, as part of its Guidance to the NHS in England and Wales, and informing the deliberations of the NICE Research and Development Committee. Objectives - The specific objectives of the pilot study were to: • Demonstrate the benefits of using appropriate decision analytic methods and value of information analysis to inform research recommendations. • Establish the feasibility and resource implications of applying these methods in a timely way, to inform NICE. • Identify critical issues and methodological challenges to the use of value of information methods for research recommendations (with particular regard to the new reference case as a suitable basis for this type of analysis).

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Probiotics and mastitis: evidence-based marketing?

Probiotics are defined as live micro-organisms, which when administered in adequate amounts, confer health benefits on the host. Scientists have isolated various strains of Lactobacilli from human milk (such as Lactobacillus fermentum and Lactobacillus salivarius), and the presence of these organisms is thought to be protective against breast infections, or mastitis. Trials of probiotics for treating mastitis in dairy cows have had mixed results: some successful and others unsuccessful. To date, only one trial of probiotics to treat mastitis in women and one trial to prevent mastitis have been published. Although trials of probiotics to prevent mastitis in breastfeeding women are still in progress, health professionals in Australia are receiving marketing of these products. High quality randomised controlled trials are needed to assess the effectiveness of probiotics for the prevention and/or treatment of mastitis

Realist evaluation of UK medical education quality assurance

OBJECTIVES: The aim of the study was to explore what components of the General Medical Council's (GMC) Quality Assurance Framework work, for whom, in what circumstances and how? SETTING: UK undergraduate and postgraduate medical education and training. PARTICIPANTS: We conducted interviews with a stratified sample of 36 individuals. This included those who had direct experiences, as well as those with external insights, representing local, national and international organisations within and outside medicine. INTERVENTION: The GMC quality assure education to protect patient and public safety utilising complex intervention components including meeting standards, institutional visits and monitoring performance. However, the context in which these are implemented matters. We undertook an innovative realist evaluation to test an initial programme theory. Data were analysed using framework analysis. RESULTS: Across components of the intervention, we identified key mechanisms, including transparent reporting to promote quality improvement; dialogical feedback; partnership working facilitating interactions between regulators and providers, and role clarity in conducting proportionate interventions appropriate to risk. The GMC's framework was commended for being comprehensive and enabling a broad understanding of an organisation's performance. Unintended consequences included confusion over roles and boundaries in different contexts which often undermined effectiveness. CONCLUSIONS: This realist evaluation substantiates the literature and reveals deeper understandings about quality assuring medical education. While standardised approaches are implemented, interventions need to be contextually proportionate. Routine communication is beneficial to verify data, share concerns and check risk; however, ongoing partnership working can foster assurance. The study provides a modified programme theory to explicate how education providers and regulators can work more effectively together to uphold education quality, and ultimately protect public safety. The findings have influenced the GMC's approach to quality assurance which impacts on all medical students and doctors in training