Otto Greiffenstein una voz FM

Lo que más recuerdo de Ottico es que me hacía cosquillas en el dedo índice con su bigote. A Sello Negro (su caballo) y verlo siempre con un tanque de oxígeno verde al lado de su cama. Tres años, 11 meses y 28 días, definitivamente no fueron suficientes para conocer al personaje que todos me cuentan que fue. Para mí siempre ha sido y será, simplemente, mi abuelo o como mi papá dice, mi ángel de la guarda.Comunicador (a) SocialPregrad

El retorno al trabajo de las personas en condición de discapacidad en Colombia. Un análisis a la luz de la realidad

Un análisis que permite evidenciar la coyuntura real del retorno de las personas en condición de discapacidad a sus labores, , en Colombia, donde la reubicación o retorno de esta población, ha sido la causante de controversias en tres vías; no únicamente desde el punto de vista del trabajador, sino también por parte del Estado y el empleador, lo que exige que este tema sea abordado desde múltiples perspectivas que desentrañen esta realidad. La primer de estas es el Estado cuando se enfrenta con el reto de identificar los principales obstáculos del retorno de la población discapacitada, esto con el fin comprender y establecer criterios reales que estimulen en la práctica cambios positivos frente a este fenómeno social. En cuanto al empleador, es necesario comprender los factores que incrementan la violación de los derechos del trabajador; es decir, la dicotomía que existe entre la estabilidad laboral que el empleador debe garantizar y la productividad. Lo anterior debido a la naturaleza capitalista de las empresas y a la necesidad de contar con personal completamente “óptimo” con el fin de explotar su capacidad de trabajo, cosificando al trabajador y catalogándolo como un objeto de producción.An analysis that makes it possible to show the real situation of the return of persons with disabilities to their work, in Colombia, where the relocation or return of this population has been the cause of controversies in three ways; not only from the point of view of the worker, but also by the State and the employer, which requires that this issue be approached from multiple perspectives that unravel this reality. The first of these is the State when faced with the challenge of identifying the main obstacles to the return of the disabled population, this in order to understand and establish real criteria that stimulate in practice positive changes in the face of this social phenomenon. As for the employer, it is necessary to understand the factors that increase the violation of the worker's rights; that is, the dichotomy that exists between job stability that the employer must guarantee and productivity. This is due to the capitalist nature of the companies and the need to have completely "optimal" personnel in order to exploit their work capacity, reifying the worker and classifying it as an object of production.Abogado (a)Pregrad

Facultad de Ciencias : educación, investigación y proyección social

ilustraciones, fotografíasCon motivo del sesquicentenario de la Universidad Nacional de Colombia, conmemorado en septiembre de 2017, la Facultad de Ciencias presenta una reflexión histórica sobre su proyección en el desarrollo de las ciencias básicas en el país, teniendo en cuenta que es en la actualidad la facultad de Ciencias Naturales más antigua de Colombia. Esta reflexión, producto de un proceso de investigación interdisciplinario, es una forma de construir identidad y de recuperar la memoria para entender los procesos de gestación, nacimiento, desarrollo y proyección de las comunidades académicas y científicas que confluyen en la Facultad. Significa revisar el pasado desde miradas plurales construidas en la experiencia de años y décadas transitando por salones, auditorios, laboratorios y corredores de las variadas arquitecturas que habitamos, desglosando los saberes heredados y armando los nuevos a partir de la permanente pregunta por lo desconocido. Pero esta reflexión no quiere escribir la historia de la Facultad, empresa por demás necesaria pero imposible pues no hay “una historia”, sino tantas historias como quieran tejer sus intérpretes desde las múltiples facetas de los acontecimientos. (texto tomado de la fuente)La Facultad de Ciencias: educación, investigación y proyección social -- Introducción -- La Facultad de Ciencias y las profesiones y disciplinas científicas en Colombia -- Institucionalización y profesionalización de las Ciencias Naturales y las Matemáticas en el siglo xix -- Las Ciencias Naturales y las Matemáticas en la Universidad Nacional de los Estados Unidos de Colombia -- Las Ciencias Naturales y las Matemáticas en la Universidad Nacional de Colombia (1936). -- Primeros pasos en investigación -- Elementos de contexto, 1930-1965 -- Las Ciencias Naturales y las Matemáticas en la nueva Facultad de Ciencias. La Reforma Patiño -- ¿Por qué una reforma? -- Organización actual de la Universidad . 41 La Facultad de Ciencias, 1965-1992 -- La Facultad de Ciencias de 1992 hasta nuestros días -- La Facultad de Ciencias y la investigación científica -- Primeros pasos en investigación, 1936-1970 -- La investigación en la nueva Facultad de Ciencias (1970-2017) -- Desarrollo de la investigación en el Departamento de Biología y el Instituto de Ciencias Naturales -- Desarrollo de la investigación en el Departamento de Estadística -- Desarrollo de la investigación en el Departamento deFarmacia -- Desarrollo de la investigación en el Departamento de Física -- Desarrollo de la investigación en el Departamento de Geociencias -- Desarrollo de la investigación en el Departamento de Matemáticas -- Desarrollo de la investigación en el Departamento de Química -- Desarrollo de la investigación en el Observatorio Astronómico Nacional -- Proyección social de la Facultad de Ciencias -- Extensión en la Facultad de Ciencias -- Proyección de la Facultad hacia la ciencia escolar, las universidades de provincia y la sociedad en general -- Cursos libres juveniles -- Maestría en Enseñanza de las Ciencias Exactas y Naturales -- Cursos de actualización o de profundización -- Otros cursos -- Diplomados -- Servicio docente asistencial -- Contribución de la Facultad de Ciencias al desarrollo de la Física y la Matemática en algunas universidades de provincia -- Proyección de la Facultad de Ciencias a través de programas de otras unidades académicas de la Universidad -- La Facultad de Ciencias y sus museos -- Introducción -- El Museo Nacional y la Universidad -- Los museos de la Facultad -- La Facultad de Ciencias y las asociaciones y sociedades científicas y profesionales en Colombia -- Asociaciones y sociedades de biólogos -- Asociaciones y sociedades de estadísticos -- Colegio y Sociedad de Químicos Farmacéuticos -- Sociedad Colombiana de Física (scf) y Asociación Nacional de Físicos -- Sociedades y asociaciones de geólogos y geofísicos -- Sociedad Colombiana de Geología -- Asociación Colombiana de Geólogos y Geofísicos del Petróleo (acggp) -- Asociación de Geólogos Egresados de la Universidad Nacional de Colombia (Agunal) -- Sociedad Colombiana de Matemáticas (scm) -- Publicaciones -- Eventos -- Sociedades y asociaciones de químicos -- Academias y sociedades del Observatorio Astronómico Nacional -- Academia Colombiana de Ciencias Exactas, Físicas y Naturales -- La Facultad de Ciencias y la comunicación científica -- Antecedentes -- La ciencia en los Anales de la Universidad -- Productos de difusión especializada -- Revistas especializadas -- Series científicas del Instituto de Ciencias Naturales -- Productos de divulgación científica -- Programa Cuclí-Cuclí – Otros productos de divulgación escrita -- Programas radiales -- Ciclos de conferencias, coloquios y conversatorios de temáticas científicas -- Productos de divulgación didáctica -- Cátedras universitarias de sede -- Textos de clase -- Colecciones recientes – Epílogo – Autores – Anexos -- Anexo 1. Rectores de la Universidad Nacional de Colombia y presidentes de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales -- Anexo 2. Premios y mencionesPrimera edició

Manganese and acute paranoid psychosis: a case report

Contains fulltext : 103167.pdf (publisher's version ) (Open Access)Introduction Manganese regulates many enzymes and is essential for normal development and body function. Chronic manganese intoxication has an insidious and progressive course and usually starts with complaints of headache, fatigue, sleep disturbances, irritability and emotional instability. Later, several organ systems may be affected and, due to neurotoxicity, an atypical parkinsonian syndrome may emerge. With regard to neuropsychiatry, an array of symptoms may develop up to 30 years after intoxication, of which gait and speech abnormalities, cognitive and motor slowing, mood changes and hallucinations are the most common. Psychotic phenomena are rarely reported. Case presentation We describe the case of a 49-year-old Caucasian man working as a welder who was referred to our facility for evaluation of acute paranoid psychotic behavior. Our patient's medical history made no mention of any somatic complaints or psychiatric symptoms, and he had been involved in a professional career as a metalworker. On magnetic resonance imaging scanning of his brain, a bilateral hyperdensity of the globus pallidus, suggestive for manganese intoxication, was found. His manganese serum level was 52 to 97 nmol/L (range: 7 to 20 nmol/L). A diagnosis of organic psychotic disorder due to manganese overexposure was made. His psychotic symptoms disappeared within two weeks of treatment with low-dose risperidone. At three months later, serum manganese was decreased to slightly elevated levels and the magnetic resonance imaging T1 signal intensity was reduced. No signs of Parkinsonism were found and a definite diagnosis of manganese-induced apathy syndrome was made. Conclusion Although neuropsychiatric and neurological symptoms caused by (chronic) manganese exposure have been reported frequently in the past, in the present day the disorder is rarely diagnosed. In this report we stress that manganese intoxication can still occur, in our case in a confined-space welder, and may present clinically with a paranoid psychotic state that necessitates a rapid diagnostic procedure in order to avoid the permanent structural brain damage that may occur with chronic exposure.4 p

Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients-A Prospective Multicenter Study (IROI Study)

To identify the prevalence, risk factors, and outcomes of intra-abdominal hypertension in a mixed multicenter ICU population. Prospective observational study. Fifteen ICUs worldwide. Consecutive adult ICU patients with a bladder catheter. None. Four hundred ninety-one patients were included. Intra-abdominal pressure was measured a minimum of every 8 hours. Subjects with a mean intra-abdominal pressure equal to or greater than 12 mm Hg were defined as having intra-abdominal hypertension. Intra-abdominal hypertension was present in 34.0% of the patients on the day of ICU admission (159/467) and in 48.9% of the patients (240/491) during the observation period. The severity of intra-abdominal hypertension was as follows: grade I, 47.5%; grade II, 36.6%; grade III, 11.7%; and grade IV, 4.2%. The severity of intra-abdominal hypertension during the first 2 weeks of the ICU stay was identified as an independent predictor of 28-and 90-day mortality, whereas the presence of intra-abdominal hypertension on the day of ICU admission did not predict mortality. Body mass index, Acute Physiology and Chronic Health Evaluation II score greater than or equal to 18, presence of abdominal distension, absence of bowel sounds, and positive end-expiratory pressure greater than or equal to 7 cm H2O were independently associated with the development of intra-abdominal hypertension at any time during the observation period. In subjects without intra-abdominal hypertension on day 1, body mass index combined with daily positive fluid balance and positive end-expiratory pressure greater than or equal to 7 cm H2O (as documented on the day before intra-abdominal hypertension occurred) were-associated with the development of intraabdominal hypertension during the first week in the ICU. In our mixed ICU patient cohort, intra-abdominal hypertension occurred in almost half of all subjects and was twice as prevalent in mechanically ventilated patients as in spontaneously breathing patients. Presence and severity of intra-abdominal hypertension during the observation period significantly and independently increased 28-and 90-day mortality. Five admission day variables were independently associated with the presence or development of intra-abdominal hypertension. Positive fluid balance was associated with the development of intra-abdominal hypertension after day 1474535542NIGMS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of General Medical Sciences (NIGMS) [U54 GM104940

Treatment course and outcomes following drug and alcohol-related traumatic injuries

Both authors are with the NeuroTexas Institute at St. David's HealthCare, St. David's Medical Center, 1015 East 32nd Street, Suite 404, Austin, Texas 78705, USA -- Matthew C. Cowperthwaite is with the Center for Systems and Synthetic Biology, The University of Texas at Austin, 1 University Station, A4800, Austin, Texas 78712, USABackground: Alcohol and drug use is known to be a major factor affecting the incidence of traumatic injury. However, the ways in which immediate pre-injury substance use affects patients' clinical care and outcomes remains unclear. The goal of the present study is to determine the associations between pre-injury use of alcohol or drugs and patient injury severity, hospital course, and clinical outcome. Materials and methods: This study used more than 200,000 records from the National Trauma Data Bank (NTDB), which is the largest trauma registry in the United States. Incidents in the NTDB were placed into one of four classes: alcohol related, drug related, alcohol-and-drug related, and substance negative. Logistic regression models were used to determine comorbid conditions or treatment complications that were significantly associated with pre-injury substance use. Hospital charges were associated with the presence or absence of drugs and alcohol, and patient outcomes were assessed using discharge disposition as delimited by the NTDB. Results: The rates of complications arising during treatment were 8.3, 10.9, 9.9 and 8.6 per one hundred incidents in the alcohol related, drug related, alcohol-and-drug related, and substance-negative classes, respectively. Regression models suggested that pre-injury alcohol use is associated with a 15% higher risk of infection, whereas pre-injury drug use is associated with a 30% higher risk of infection. Pre-injury substance use did not appear to significantly impact clinical outcomes following treatment for traumatic injury, however. Conclusion: This study suggests that pre-injury drug use is associated with a significantly higher complication rate. In particular, infection during hospitalization is a significant risk for both alcohol and drug related trauma visits, and drug-related trauma incidents are associated with increased risk for additional circulatory complications. Although drug and alcohol related trauma incidents are not associated with appreciably worse clinical outcomes, patients experiencing such complications are associated with significantly greater length of stay and higher hospitalization costs. Therefore significant benefits to trauma patients could be gained with enhanced surveillance for pre-injury substance use upon admission to the ED, and closer monitoring for infection or circulatory complications during their period of hospitalization.Center for Systems and Synthetic [email protected]

Contribution of brain or biological reserve and cognitive or neural reserve to outcome after TBI: a meta-analysis (prior to 2015)

Brain/biological (BR) and cognitive/neural reserve (CR) have increasingly been used to explain some of the variability that occurs as a consequence of normal ageing and neurological injuries or disease. However, research evaluating the impact of reserve on outcomes after adult traumatic brain injury (TBI) has yet to be quantitatively reviewed. This meta-analysis consolidated data from 90 studies (published prior to 2015) that either examined the relationship between measures of BR (genetics, age, sex) or CR (education, premorbid IQ) and outcomes after TBI or compared the outcomes of groups with high and low reserve. The evidence for genetic sources of reserve was limited and often contrary to prediction. APOE ∈4 status has been studied most, but did not have a consistent or sizeable impact on outcomes. The majority of studies found that younger age was associated with better outcomes, however most failed to adjust for normal age-related changes in cognitive performance that are independent of a TBI. This finding was reversed (older adults had better outcomes) in the small number of studies that provided age-adjusted scores; although it remains unclear whether differences in the cause and severity of injuries that are sustained by younger and older adults contributed to this finding. Despite being more likely to sustain a TBI, males have comparable outcomes to females. Overall, as is the case in the general population, higher levels of education and pre-morbid IQ are both associated with better outcomes.Jane L. Mathias, Patricia Wheato

Impairments in Episodic-Autobiographical Memory and Emotional and Social Information Processing in CADASIL during Mid-Adulthood

Staniloiu A, Woermann FG, Markowitsch HJ. Impairments in Episodic-Autobiographical Memory and Emotional and Social Information Processing in CADASIL during Mid-Adulthood. Frontiers in Behavioral Neuroscience. 2014;8: 227.Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) – is the most common genetic source of vascular dementia in adults, being caused by a mutation in NOTCH3 gene. Spontaneous de novo mutations may occur, but their frequency is largely unknown. Ischemic strokes and cognitive impairments are the most frequent manifestations, but seizures affect up to 10% of the patients. Herein, we describe a 47-year-old male scholar with a genetically confirmed diagnosis of CADASIL (Arg133Cys mutation in the NOTCH3 gene) and a seemingly negative family history of CADASIL illness, who was investigated with a comprehensive neuropsychological testing battery and neuroimaging methods. The patient demonstrated on one hand severe and accelerated deteriorations in multiple cognitive domains such as concentration, long-term memory (including the episodic-autobiographical memory domain), problem solving, cognitive flexibility and planning, affect recognition, discrimination and matching, and social cognition (theory of mind). Some of these impairments were even captured by abbreviated instruments for investigating suspicion of dementia. On the other hand the patient still possessed high crystallized (verbal) intelligence and a capacity to put forth a façade of well-preserved intellectual functioning. Although no definite conclusions can be drawn from a single case study, our findings point to the presence of additional cognitive changes in CADASIL in middle adulthood, in particular to impairments in the episodic-autobiographical memory domain and social information processing (e.g., social cognition). Whether these identified impairments are related to the patient’s specific phenotype or to an ascertainment bias (e.g., a paucity of studies investigating these cognitive functions) requires elucidation by larger scale research