Universal aging properties at a disordered critical point

We investigate, analytically near the dimension $d_{uc}=4$ and numerically in $d=3$, the non equilibrium relaxational dynamics of the randomly diluted Ising model at criticality. Using the Exact Renormalization Group Method to one loop, we compute the two times $t,t_w$ correlation function and Fluctuation Dissipation Ratio (FDR) for any Fourier mode of the order parameter, of finite wave vector $q$. In the large time separation limit, the FDR is found to reach a non trivial value $X^{\infty}$ independently of (small) $q$ and coincide with the FDR associated to the the {\it total} magnetization obtained previously. Explicit calculations in real space show that the FDR associated to the {\it local} magnetization converges, in the asymptotic limit, to this same value $X^{\infty}$. Through a Monte Carlo simulation, we compute the autocorrelation function in three dimensions, for different values of the dilution fraction $p$ at $T_c(p)$. Taking properly into account the corrections to scaling, we find, according to the Renormalization Group predictions, that the autocorrelation exponent $\lambda_c$ is independent on $p$. The analysis is complemented by a study of the non equilibrium critical dynamics following a quench from a completely ordered state.Comment: 8 pages, 5 figure

Water Quality Monitoring in the Buck Creek Watershed and Facilitation of Buck Creek Watershed Partnership

The “Water Quality Monitoring in the Buck Creek Watershed and Facilitation of Buck Creek Watershed Partnership” project was developed to continue water quality monitoring on Buck Creek and to continue to engage watershed stakeholders during the Buck Creek WPP review process. This project continued monthly monitoring of Buck Creek when flowing water was present and kept the watershed partnership engaged through public meetings and semi-annual newsletters. Water quality monitoring began in May 2011 during the early stages of the most intense one-year drought on record in Texas and ran through April 2013. While much of the state returned to a semi-normal state of moisture conditions, the Texas Panhandle did not fare so well. The drought coupled with increased groundwater pumping to keep crops viable yielded sufficient water to sample in the creek during four sampling dates in this two-year period

Non equilibrium dynamics below the super-roughening transition

The non equilibrium relaxational dynamics of the solid on solid model on a disordered substrate and the Sine Gordon model with random phase shifts is studied numerically. Close to the super-roughening temperature $T_g$ our results for the autocorrelations, spatial correlations and response function as well as for the fluctuation dissipation ratio (FDR) agree well with the prediction of a recent one loop RG calculation, whereas deep in the glassy low temperature phase substantial deviations occur. The change in the low temperature behavior of these quantities compared with the RG predictions is shown to be contained in a change of the functional temperature dependence of the dynamical exponent $z(T)$, which relates the age $t$ of the system with a length scale ${\cal L}(t)$: $z(T)$ changes from a linear $T$-dependence close to $T_g$ to a 1/T-behavior far away from $T_g$. By identifying spatial domains as connected patches of the exactly computable ground states of the system we demonstrate that the growing length scale ${\cal L}(t)$ is the characteristic size of thermally fluctuating clusters around ``typical'' long-lived configurations.Comment: RevTex

Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations

Drug resistance, de novo and acquired, pervades cellular signaling networks (SNs) from one signaling motif to another as a result of cancer progression and/or drug intervention. This resistance is one of the key determinants of efficacy in targeted anti-cancer drug therapy. Although poorly understood, drug resistance is already being addressed in combination therapy by selecting drug targets where SN sensitivity increases due to combination components or as a result of de novo or acquired mutations. Additionally, successive drug combinations have shown low resistance potential. To promote a rational, systematic development of combination therapies, it is necessary to establish the underlying mechanisms that drive the advantages of combination therapies, and design methods to determine drug targets for combination regimens. Based on a joint systems analysis of cellular SN response and its sensitivity to drug action and oncogenic mutations, we describe an in silico method to analyze the targets of drug combinations. Our method explores mechanisms of sensitizing the SN through a combination of two drugs targeting vertical signaling pathways. We propose a paradigm of SN response customization by one drug to both maximize the effect of another drug in combination and promote a robust therapeutic response against oncogenic mutations. The method was applied to customize the response of the ErbB/PI3K/PTEN/AKT pathway by combination of drugs targeting HER2 receptors and proteins in the down-stream pathway. The results of a computational experiment showed that the modification of the SN response from hyperbolic to smooth sigmoid response by manipulation of two drugs in combination leads to greater robustness in therapeutic response against oncogenic mutations determining cancer heterogeneity. The application of this method in drug combination co-development suggests a combined evaluation of inhibition effects together with the capability of drug combinations to suppress resistance mechanisms before they become clinically manifest

Circumventing the eta problem in building an inflationary model in string theory

The eta problem is one of the most significant obstacles to building a successful inflationary model in string theory. Planck mass suppressed corrections to the inflaton potential generally lead to inflaton masses of order the Hubble scale and generate contributions of order unity to the eta slow roll parameter rendering prolonged slow roll inflation impossible. We demonstrate the severity of this problem in the context of brane anti-brane inflation in a warped throat of a Calabi-Yau flux compactification with all phenomenologically dangerous moduli stabilized. Using exact numerical solutions we show that the eta problem can be avoided in scenarios where the inflaton is non-minimally coupled to gravity and has Dirac-Born-Infeld (DBI) kinetic term. We show that the resulting cosmic microwave background (CMB) observables such as measures of non-gaussianites can, in principle, serve as a probe of scalar-gravity couplings.Comment: 8 pages, 3 figures; title changed and reference added to match published version in PR

Constraints on the Intergalactic Transport of Cosmic Rays

Motivated by recent experimental proposals to search for extragalactic cosmic rays (including anti-matter from distant galaxies), we study particle propagation through the intergalactic medium (IGM). We first use estimates of the magnetic field strength between galaxies to constrain the mean free path for diffusion of particles through the IGM. We then develop a simple analytic model to describe the diffusion of cosmic rays. Given the current age of galaxies, our results indicate that, in reasonable models, a completely negligible number of particles can enter our Galaxy from distances greater than $\sim 100$ Mpc for relatively low energies ($E$ $< 10^6$ GeV/n). We also find that particle destruction in galaxies along the diffusion path produces an exponential suppression of the possible flux of extragalactic cosmic rays. Finally, we use gamma ray constraints to argue that the distance to any hypothetical domains of anti-matter must be roughly comparable to the horizon scale.Comment: 24 pages, AAS LaTex, 1 figure, accepted to Ap

Defining the gap between research and practice in public relations programme evaluation - towards a new research agenda

The current situation in public relations programme evaluation is neatly summarized by McCoy who commented that 'probably the most common buzzwords in public relations in the last ten years have been evaluation and accountability' (McCoy 2005, 3). This paper examines the academic and practitioner-based literature and research on programme evaluation and it detects different priorities and approaches that may partly explain why the debate on acceptable and agreed evaluation methods continues. It analyses those differences and proposes a research agenda to bridge the gap and move the debate forward