The Myocardial Ischemia Reduction with Acute Cholesterol Lowering (MIRACL) trial: a new frontier for statins?

The Myocardial Ischemia Reduction with Acute Cholesterol Lowering (MIRACL) Trial tested the hypothesis that intensive lowering of cholesterol with atorvastatin (80 mg/day) initiated 24-96 h after an acute coronary syndrome would, over 4 months, reduce the incidence of the composite endpoint of death, nonfatal infarction, resuscitated cardiac arrest, and recurrent symptomatic myocardial ischemia with new objective symptoms requiring emergency rehospitalization. This primary composite endpoint was reduced from 17.4% to 14.8% (P = 0.048) among the 3086 patients enrolled. The results of MIRACL suggest that patients with acute coronary syndromes should begin to receive this treatment before leaving hospital, irrespective of baseline levels of low-density lipoprotein-cholesterol

Strong Coupling vs. 4-D Locality in Induced Gravity

We re-examine the problem of strong coupling in a regularized version of DGP (or ``brane-induced'') gravity. We find that the regularization of ref. hep-th/0304148 differs from DGP in that it does not exhibit strong coupling or ghosts up to cubic order in the interactions. We suggest that the nonlocal nature of the theory, when written in terms of the 4-D metric, is a plausible reason for this phenomenon. Finally, we briefly discuss the possible behavior of the model at higher-order in perturbation theory.Comment: 19 pages, accepted for publication in PR

A Proterozoic microbial origin of extant cyanide-hydrolyzing enzyme diversity

In addition to its role as a toxic environmental contaminant, cyanide has been hypothesized to play a key role in prebiotic chemistry and early biogeochemical evolution. While cyanide-hydrolyzing enzymes have been studied and engineered for bioremediation, the extant diversity of these enzymes remains underexplored. Additionally, the age and evolution of microbial cyanide metabolisms is poorly constrained. Here we provide comprehensive phylogenetic and molecular clock analyses of the distribution and evolution of the Class I nitrilases, thiocyanate hydrolases, and nitrile hydratases. Molecular clock analyses indicate that bacterial cyanide-reducing nitrilases were present by the Paleo- to Mesoproterozoic, and were subsequently horizontally transferred into eukaryotes. These results present a broad diversity of microbial enzymes that could be optimized for cyanide bioremediation

Low field vortex matter in YBCO: an atomic beam magnetic resonance study

We report measurements of the low field structure of the magnetic vortex lattice in an untwinned YBCO single-crystal platelet. Measurements were carried out using a novel atomic beam magnetic resonance (ABMR) technique. For a 10.7 G field applied parallel to the c-axis of the sample, we find a triangular lattice with orientational order extending across the entire sample. We find the triangular lattice to be weakly distorted by the a-b anisotropy of the material and measure a distortion factor, f = 1.16. Model-experiment comparisons determine a penetration depth, lambda_ab = 140 (+-20) nm. The paper includes the first detailed description of the ABMR technique. We discuss both technical details of the experiment and the modeling used to interpret the measurements.Comment: 44 pages, 13 figures, submitted to Phys. Rev. B Revision includes Postscript wrapped figures + minor typo

Locally Localized Gravity Models in Higher Dimensions

We explore the possibility of generalizing the locally localized gravity model in five space-time dimensions to arbitrary higher dimensions. In a space-time with negative cosmological constant, there are essentially two kinds of higher-dimensional cousins which not only take an analytic form but also are free from the naked curvature singularity in a whole bulk space-time. One cousin is a trivial extension of five-dimensional model, while the other one is in essence in higher dimensions. One interesting observation is that in the latter model, only anti-de Sitter ($AdS_p$) brane is physically meaningful whereas de Sitter ($dS_p$) and Minkowski ($M_p$) branes are dismissed. Moreover, for $AdS_p$ brane in the latter model, we study the property of localization of various bulk fields on a single brane. In particular, it is shown that the presence of the brane cosmological constant enables bulk gauge field and massless fermions to confine to the brane only by a gravitational interaction. We find a novel relation between mass of brane gauge field and the brane cosmological constant.Comment: 20 pages, LaTex 2e, revised version (to appear in Phys. Rev. D

Effects of dalcetrapib in patients with a recent acute coronary syndrome

In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels and might therefore improve cardiovascular outcomes

Ghost-free braneworld bigravity

We consider a generalisation of the DGP model, by adding a second brane with localised curvature, and allowing for a bulk cosmological constant and brane tensions. We study radion and graviton fluctuations in detail, enabling us to check for ghosts and tachyons. By tuning our parameters accordingly, we find bigravity models that are free from ghosts and tachyons. These models will lead to large distance modifications of gravity that could be observable in the near future.Comment: Dedicated to the memory of Ian Kogan. Version to appear in Classical and Quantum Gravit

COPD- dependent effects of genetic variation in key inflammation pathway genes on lung cancer risk

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155975/1/ijc32780.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155975/2/ijc32780-sup-0001-Supinfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155975/3/ijc32780_am.pd

Bispectrum speckle interferometry observations and radiative transfer modelling of the red supergiant NML Cyg: Multiple dust-shell structures evidencing previous superwind phases

(abridged) NML Cyg is a highly evolved OH/IR supergiant and supposed to be among the most luminous supergiants in the galaxy. We present the first diffraction limited 2.13micron observations of NML Cyg with 73mas resolution. The speckle interferograms were obtained with the SAO 6m telescope, image reconstruction is based on the bispectrum speckle interferometry method. Radiative transfer calculations have been carried out to model the spectral energy distribution, our 2.13micron visibility function, and mid-infrared visibility functions. The observed dust shell properties do not appear to be in accordance with single-shell models but seem to require multiple components. Considering previous periods of enhanced mass-loss, various density enhancements in the dust shell were taken into account. An extensive grid of models was calculated for different locations and strenghts of such superwind regions in the dust shell. To match the observations from the optical to the sub-mm domain requires at least two superwind regions embedded in the shell. The best model includes a dust shell with a temperature of 1000K at its inner radius of 6.2Rstar, a close embedded superwind shell extending from 15.5Rstar to 21.7Rstar with amplitude 10 (factor of density enhancement), and a far-out density enhancement at 186Rstar with amplitude 5. The angular diameter of the inner dust-shell rim amounts to 105mas. Within the various parts of the dust shell, 1/r^2 density distributions could be maintained differing only in their amplitude A. The present-day mass-loss rate was determined to be 1.2 10^-4 Msol/yr. The inner embedded superwind shell corresponds to a phase of enhanced mass-loss which began ~59yr ago and lasted for ~18yr, and the outer superwind region to a high mass-loss period which terminated 529yr ago.Comment: 12 pages including 13 PostScript figures, also available from http://www.mpifr-bonn.mpg.de/div/ir-interferometry/publications.html; accepted for publication in Astronomy & Astrophysic

No Time Machine Construction in Open 2+1 Gravity with Timelike Total Energy Momentum

It is shown that in 2+1 dimensional gravity an open spacetime with timelike sources and total energy momentum cannot have a stable compactly generated Cauchy horizon. This constitutes a proof of a version of Kabat's conjecture and shows, in particular, that not only a Gott pair cannot be formed from processes such as the decay of a single cosmic string as has been shown by Carroll et al., but that, in a precise sense, a time machine cannot be constructed at all.Comment: 7 pages. Several changes and 3 figures added. To appear in Phys. Rev.