2,222 research outputs found
Consciousness and the Physical World
The main file in this deposition is a pdf file containing the scanned pages of the Proceedings. Additional files OCR.txt and OCR.pdf (the latter having the same pagination as the book) are included to simplify search, etc. Because of their automated creation using software, the accuracy of the OCR files cannot be guaranteed, though some checking has been carried out.
In the scanned version, entering 'go to page n' in a pdf reader will access the pair of pages 2n and 2n+1. Alternatively, go to the contents pages (accessible via 'go to page', entering 'contents' at the prompt) for the numbers to use with 'go to' for specific chapters.
© By arrangement with the publishers, the editors (Brian D Josephson and Vilayanur S Ramachandran) are the present copyright holders. They grant permission for the use of the material in this book in accord with the terms of the CC licence below.Edited proceedings of an interdisciplinary symposium on consciousness held at
the University of Cambridge in January 1978. The purpose of the Cambridge
conference was to encourage distinguished scientists to express their views on
the relationship of conscious experience to the physical world.The conference was supported by a grant from Research Corporation of New York
Can latent heat safely warm blood? – in vitro testing of a portable prototype blood warmer
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background
Trauma/retrieval patients are often in shock and hypothermic. Treatment of such patients usually involves restoring their blood volume with transfusion of blood (stored at 2°C – 6°C) and/or crystalloids or colloids (stored at ambient temperature). Rapid infusion of these cold fluids can worsen or even induce hypothermia in these patients. Warming of intravenous fluids at accident sites has traditionally been difficult due to a lack of suitable portable fluid warmers that are not dependent on mains electrical or battery power. If latent heat, the heat released when a liquid solidifies (an inherently temperature limiting process) can warm intravenous fluids, portable devices without a reliance on electrical energy could be used to reduce the incidence of hypothermia in trauma patients.
Methods
Rapid infusion of red cells into patients was timed to sample typical clinical flow rates.
An approved dry heat blood warmer was compared with a prototype blood warmer using a supercooled liquid latent heat storage material, to warm red cells whilst monitoring inlet and outlet temperatures. To determine the effect of warming on red cell integrity compared to the normal storage lesion of blood, extracellular concentrations of potassium, lactate dehydrogenase and haemoglobin were measured in blood which had been warmed after storage at 2°C – 6°C for 1 to 42 days.
Results
A prototype latent heat fluid warmer consistently warmed red cells from approximately 4°C to approximately 35°C at typical clinical flow rates. Warming of stored blood with latent heat did not affect red cell integrity more than the approved dry heat blood warmer.
Conclusion
Using latent heat as an energy source can satisfactorily warm cold blood or other intravenous fluids to near body temperature, without any adverse affects
Bayesian Methods for Exoplanet Science
Exoplanet research is carried out at the limits of the capabilities of
current telescopes and instruments. The studied signals are weak, and often
embedded in complex systematics from instrumental, telluric, and astrophysical
sources. Combining repeated observations of periodic events, simultaneous
observations with multiple telescopes, different observation techniques, and
existing information from theory and prior research can help to disentangle the
systematics from the planetary signals, and offers synergistic advantages over
analysing observations separately. Bayesian inference provides a
self-consistent statistical framework that addresses both the necessity for
complex systematics models, and the need to combine prior information and
heterogeneous observations. This chapter offers a brief introduction to
Bayesian inference in the context of exoplanet research, with focus on time
series analysis, and finishes with an overview of a set of freely available
programming libraries.Comment: Invited revie
Holographic fermions in charged Gauss-Bonnet black hole
We study the properties of the Green's functions of the fermions in charged
Gauss-Bonnet black hole. What we want to do is to investigate how the presence
of Gauss-Bonnet coupling constant affects the dispersion relation,
which is a characteristic of Fermi or non-Fermi liquid, as well as what
properties such a system has, for instance, the Particle-hole (a)symmetry. One
important result of this research is that we find for , the behavior of
this system is different from that of the Landau Fermi liquid and so the system
can be candidates for holographic dual of generalized non-Fermi liquids. More
importantly, the behavior of this system increasingly similar to that of the
Landau Fermi liquid when is approaching its lower bound. Also we find
that this system possesses the Particle-hole asymmetry when , another
important characteristic of this system. In addition, we also investigate
briefly the cases of the charge dependence.Comment: 22 pages, 6 figures; version published in JHE
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Irreducible uncertainty in near-term climate projections
Model simulations of the next few decades are widely used in assessments of climate change impacts and as guidance for adaptation. Their non-linear nature reveals a level of irreducible uncertainty which it is important to understand and quantify, especially for projections of near-term regional climate. Here we use large idealised initial condition ensembles of the FAMOUS global climate model with a 1 %/year compound increase in CO2 levels to quantify the range of future temperatures in model-based projections. These simulations explore the role of both atmospheric and oceanic initial conditions and are the largest such ensembles to date. Short-term simulated trends in global temperature are diverse, and cooling periods are more likely to be followed by larger warming rates. The spatial pattern of near-term temperature change varies considerably, but the proportion of the surface showing a warming is more consistent. In addition, ensemble spread in inter-annual temperature declines as the climate warms, especially in the North Atlantic. Over Europe, atmospheric initial condition uncertainty can, for certain ocean initial conditions, lead to 20 year trends in winter and summer in which every location can exhibit either strong cooling or rapid warming. However, the details of the distribution are highly sensitive to the ocean initial condition chosen and particularly the state of the Atlantic meridional overturning circulation. On longer timescales, the warming signal becomes more clear and consistent amongst different initial condition ensembles. An ensemble using a range of different oceanic initial conditions produces a larger spread in temperature trends than ensembles using a single ocean initial condition for all lead times. This highlights the potential benefits from initialising climate predictions from ocean states informed by observations. These results suggest that climate projections need to be performed with many more ensemble members than at present, using a range of ocean initial conditions, if the uncertainty in near-term regional climate is to be adequately quantified
Holographic studies of quasi-topological gravity
Quasi-topological gravity is a new gravitational theory including
curvature-cubed interactions and for which exact black hole solutions were
constructed. In a holographic framework, classical quasi-topological gravity
can be thought to be dual to the large limit of some non-supersymmetric
but conformal gauge theory. We establish various elements of the AdS/CFT
dictionary for this duality. This allows us to infer physical constraints on
the couplings in the gravitational theory. Further we use holography to
investigate hydrodynamic aspects of the dual gauge theory. In particular, we
find that the minimum value of the shear-viscosity-to-entropy-density ratio for
this model is .Comment: 45 pages, 6 figures. v2: References adde
Dipole Coupling Effect of Holographic Fermion in the Background of Charged Gauss-Bonnet AdS Black Hole
We investigate the holographic fermions in the charged Gauss-Bonnet
black hole background with the dipole coupling between fermion and gauge field
in the bulk. We show that in addition to the strength of the dipole coupling,
the spacetime dimension and the higher curvature correction in the gravity
background also influence the onset of the Fermi gap and the gap distance. We
find that the higher curvature effect modifies the fermion spectral density and
influences the value of the Fermi momentum for the appearance of the Fermi
surface. There are richer physics in the boundary fermion system due to the
modification in the bulk gravity.Comment: 16 pages, accepted for publication in JHE
Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west african populations.
Background Hepatocellular Carcinoma is the third most common cause of cancer related death worldwide, often diagnosed by measuring serum AFP; a poor performance stand-alone biomarker. With the aim of improving on this, our study focuses on plasma proteins identified by Mass Spectrometry in order to investigate and validate differences seen in the respective proteomes of controls and subjects with LC and HCC. Methods Mass Spectrometry analysis using liquid chromatography electro spray ionization quadrupole time-of-flight was conducted on 339 subjects using a pooled expression profiling approach. ELISA assays were performed on four significantly differentially expressed proteins to validate their expression profiles in subjects from the Gambia and a pilot group from Nigeria. Results from this were collated for statistical multiplexing using logistic regression analysis. Results Twenty-six proteins were identified as differentially expressed between the three subject groups. Direct measurements of four; hemopexin, alpha-1-antitrypsin, apolipoprotein A1 and complement component 3 confirmed their change in abundance in LC and HCC versus control patients. These trends were independently replicated in the pilot validation subjects from Nigeria. The statistical multiplexing of these proteins demonstrated performance comparable to or greater than ALT in identifying liver cirrhosis or carcinogenesis. This exercise also proposed preliminary cut offs with achievable sensitivity, specificity and AUC statistics greater than reported AFP averages. Conclusions The validated changes of expression in these proteins have the potential for development into high-performance tests usable in the diagnosis and or monitoring of HCC and LC patients. The identification of sustained expression trends strengthens the suggestion of these four proteins as worthy candidates for further investigation in the context of liver disease. The statistical combinations also provide a novel inroad of analyses able to propose definitive cut-offs and combinations for evaluation of performance
Hamstring stretch reflex:could it be a reproducible objective measure of functional knee stability?"
Background: The anterior cruciate ligament (ACL) plays an important role in anterior knee stability by preventing anterior translation of the tibia on the femur. Rapid translation of the tibia with respect to the femur produces an ACL-hamstring stretch reflex which may provide an object measure of neuromuscular function following ACL injury or reconstruction. The aim of this study was to determine if the ACL-hamstring stretch reflex could be reliably and consistently obtained using the KT-2000 arthrometer. Methods: A KT-2000 arthrometer was used to translate the tibia on the femur while recording the electromyography over the biceps femoris muscle in 20 participants, all with intact ACLs. In addition, a sub-group comprising 4 patients undergoing a knee arthroscopy for meniscal pathology, were tested before and after anaesthetic and with direct traction on the ACL during arthroscopy. The remaining 16 participants underwent testing to elicit the reflex using the KT-2000 only. Results: A total number of 182 trials were performed from which 70 trials elicited stretch reflex (38.5 %). The mean onset latency of the hamstring stretch reflexes was 58.9 ± 17.9 ms. The average pull force was 195 ± 47 N, stretch velocity 48 ± 35 mm/s and rate of force 19.7 ± 6.4 N/s. Conclusions Based on these results, we concluded that the response rate of the anterior cruciate ligament-hamstring reflex is too low for it to be reliably used in a clinical setting, and thus would have limited value in assessing the return of neuromuscular function following ACL injuries
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