Deep Multi-instance Networks with Sparse Label Assignment for Whole Mammogram Classification

Mammogram classification is directly related to computer-aided diagnosis of breast cancer. Traditional methods rely on regions of interest (ROIs) which require great efforts to annotate. Inspired by the success of using deep convolutional features for natural image analysis and multi-instance learning (MIL) for labeling a set of instances/patches, we propose end-to-end trained deep multi-instance networks for mass classification based on whole mammogram without the aforementioned ROIs. We explore three different schemes to construct deep multi-instance networks for whole mammogram classification. Experimental results on the INbreast dataset demonstrate the robustness of proposed networks compared to previous work using segmentation and detection annotations.Comment: MICCAI 2017 Camera Read

Rotational Evolution During Type I X-Ray Bursts

The rotation rates of six weakly-magnetic neutron stars accreting in low-mass X-ray binaries have most likely been measured by Type I X-ray burst observations with RXTE. The nearly coherent oscillations detected during the few seconds of thermonuclear burning are most simply understood as rotational modulation of brightness asymmetries on the neutron star surface. We show that, as suggested by Strohmayer and colleagues, the frequency changes of 1-2 Hz observed during bursts are consistent with angular momentum conservation as the burning shell hydrostatically expands and contracts. We calculate how vertical heat propagation through the radiative outer layers of the atmosphere and convection affect the coherence of the oscillation. We show that the evolution of the rotational profile depends strongly on whether the burning layers are composed of pure helium or mixed hydrogen/helium. Our results help explain the absence (presence) of oscillations from hydrogen-burning (helium-rich) bursts that was found by Muno and collaborators. We investigate angular momentum transport within the burning layers and the recoupling of the burning layers with the star. We show that the Kelvin-Helmholtz instability is quenched by the strong stratification, and that mixing between the burning fuel and underlying ashes by the baroclinic instability does not occur. However, the baroclinic instability may have time to operate within the differentially rotating burning layer, potentially bringing it into rigid rotation.Comment: To appear in The Astrophysical Journal; minor corrections made to tables and figure

Gravitational radiation from pulsar glitches

The nonaxisymmetric Ekman flow excited inside a neutron star following a rotational glitch is calculated analytically including stratification and compressibility. For the largest glitches, the gravitational wave strain produced by the hydrodynamic mass quadrupole moment approaches the sensitivity range of advanced long-baseline interferometers. It is shown that the viscosity, compressibility, and orientation of the star can be inferred in principle from the width and amplitude ratios of the Fourier peaks (at the spin frequency and its first harmonic) observed in the gravitational wave spectrum in the plus and cross polarizations. These transport coefficients constrain the equation of state of bulk nuclear matter, because they depend sensitively on the degree of superfluidity.Comment: 28 page

The interplay between helicity and rotation in turbulence: implications for scaling laws and small-scale dynamics

Invariance properties of physical systems govern their behavior: energy conservation in turbulence drives a wide distribution of energy among modes, observed in geophysical or astrophysical flows. In ideal hydrodynamics, the role of helicity conservation (correlation between velocity and its curl, measuring departures from mirror symmetry) remains unclear since it does not alter the energy spectrum. However, with solid body rotation, significant differences emerge between helical and non-helical flows. We first outline several results, like the energy and helicity spectral distribution and the breaking of strict universality for the individual spectra. Using massive numerical simulations, we then show that small-scale structures and their intermittency properties differ according to whether helicity is present or not, in particular with respect to the emergence of Beltrami-core vortices (BCV) that are laminar helical vertical updrafts. These results point to the discovery of a small parameter besides the Rossby number; this could relate the problem of rotating helical turbulence to that of critical phenomena, through renormalization group and weak turbulence theory. This parameter can be associated with the adimensionalized ratio of the energy to helicity flux to small scales, the three-dimensional energy cascade being weak and self-similar

Capture the fracture: a best practice framework and global campaign to break the fragility fracture cycle

Summary The International Osteoporosis Foundation (IOF) Capture the Fracture Campaign aims to support implementation of Fracture Liaison Services (FLS) throughout the world. Introduction FLS have been shown to close the ubiquitous secondary fracture prevention care gap, ensuring that fragility fracture sufferers receive appropriate assessment and intervention to reduce future fracture risk. Methods Capture the Fracture has developed internationally endorsed standards for best practice, will facilitate change at the national level to drive adoption of FLS and increase awareness of the challenges and opportunities presented by secondary fracture prevention to key stakeholders. The Best Practice Framework (BPF) sets an international benchmark for FLS, which defines essential and aspirational elements of service delivery. Results The BPF has been reviewed by leading experts from many countries and subject to beta-testing to ensure that it is internationally relevant and fit-for-purpose. The BPF will also serve as a measurement tool for IOF to award ‘Capture the Fracture Best Practice Recognition’ to celebrate successful FLS worldwide and drive service development in areas of unmet need. The Capture the Fracture website will provide a suite of resources related to FLS and secondary fracture prevention, which will be updated as new materials become available. A mentoring programme will enable those in the early stages of development of FLS to learn from colleagues elsewhere that have achieved Best Practice Recognition. A grant programme is in development to aid clinical systems which require financial assistance to establish FLS in their localities. Conclusion Nearly half a billion people will reach retirement age during the next 20 years. IOF has developed Capture the Fracture because this is the single most important thing that can be done to directly improve patient care, of both women and men, and reduce the spiralling fracture-related care costs worldwide.</p

Video Segmentation with Superpixels

Due to its importance, video segmentation has regained interest recently. However, there is no common agreement about the necessary ingredients for best performance. This work contributes a thorough analysis of various within- and between-frame affinities suitable for video segmentation. Our results show that a frame-based superpixel segmentation combined with a few motion and appearance-based affinities are sufficient to obtain good video segmentation performance. A second contribution of the paper is the extension of [1] to include motion-cues, which makes the algorithm globally aware of motion, thus improving its performance for video sequences. Finally, we contribute an extension of an established image segmentation benchmark [1] to videos, allowing coarse-to-fine video segmentations and multiple human annotations. Our results are tested on BMDS [2], and compared to existing methods

A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix

To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (RT-PCR) and cDNA sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (CINs)]. We also examined a link between the occurrence of the aberrant expression and human papillomavirus (HPV). We detected the aberrant FHIT transcripts in 11 of 25 (44%) cervical invasive squamous cell carcinomas and in 5 of 14 (36%) high-grade CINs (CIN 2 or 3), whereas they were not found in seven non-squamous type and four low-grade CINs (CIN 1). The alteration patterns of the FHIT gene expression in high-grade CINs were virtually similar to those found in invasive carcinomas, such that the exons 5–7 were consistently deleted associated or unassociated with loss of the exon 4 and/or 8. The incidence of the aberrant expression was not related to the presence of HPV and its type. These data indicate that the aberrant expression of the FHIT gene is observed in precursor lesions of cervical carcinoma as well as invasive carcinomas, with its incidence not increasing with advance of clinical stage. Given the squamous cell type dominant expression, the aberrant expression may play a critical role in the generation of squamous cell carcinoma of the uterine cervix, but not the consequence of the progression of the cancer. © 1999 Cancer Research Campaig

Observability of the Bulk Casimir Effect: Can the Dynamical Casimir Effect be Relevant to Sonoluminescence?

The experimental observation of intense light emission by acoustically driven, periodically collapsing bubbles of air in water (sonoluminescence) has yet to receive an adequate explanation. One of the most intriguing ideas is that the conversion of acoustic energy into photons occurs quantum mechanically, through a dynamical version of the Casimir effect. We have argued elsewhere that in the adiabatic approximation, which should be reliable here, Casimir or zero-point energies cannot possibly be large enough to be relevant. (About 10 MeV of energy is released per collapse.) However, there are sufficient subtleties involved that others have come to opposite conclusions. In particular, it has been suggested that bulk energy, that is, simply the naive sum of ${1\over2}\hbar\omega$, which is proportional to the volume, could be relevant. We show that this cannot be the case, based on general principles as well as specific calculations. In the process we further illuminate some of the divergence difficulties that plague Casimir calculations, with an example relevant to the bag model of hadrons.Comment: 13 pages, REVTe

Where will the dhole survive in 2030? Predicted strongholds in mainland Southeast Asia

Dhole (Cuon alpinus) is threatened with extinction across its range due to habitat loss and prey depletion. Despite this, no previous study has investigated the distribution and threat of the species at a regional scale. This lack of knowledge continues to impede conservation planning for the species. Here we modeled suitable habitat using presence-only camera trap data for dhole and dhole prey species in mainland Southeast Asia and assessed the threat level to dhole in this region using an expert-informed Bayesian Belief Network. We integrated prior information to identify dhole habitat strongholds that could support populations over the next 50 years. Our habitat suitability model identified forest cover and prey availability as the most influential factors affecting dhole occurrence. Similarly, our threat model predicted that forest loss and prey depletion were the greatest threats, followed by local hunting, non-timber forest product collection, and domestic dog incursion into the forest. These threats require proactive resource management, strong legal protection, and cross-sector collaboration. We predicted &lt;20% of all remaining forest cover in our study area to be suitable for dhole. We then identified 17 patches of suitable forest area as potential strongholds. Among these patches, Western Forest Complex (Thailand) was identified as the region's only primary stronghold, while Taman Negara (Malaysia), and northeastern landscape (Cambodia) were identified as secondary strongholds. Although all 17 patches met our minimum size criteria (1667 km(2)), patches smaller than 3333 km(2) may require site management either by increasing the ecological carrying capacity (i.e., prey abundance) or maintaining forest extent. Our proposed interventions for dhole would also strengthen the conservation of other co-occurring species facing similar threats. Our threat assessment technique of species with scarce information is likely replicable with other endangered species