16,020 research outputs found
PriPeARL: A Framework for Privacy-Preserving Analytics and Reporting at LinkedIn
Preserving privacy of users is a key requirement of web-scale analytics and
reporting applications, and has witnessed a renewed focus in light of recent
data breaches and new regulations such as GDPR. We focus on the problem of
computing robust, reliable analytics in a privacy-preserving manner, while
satisfying product requirements. We present PriPeARL, a framework for
privacy-preserving analytics and reporting, inspired by differential privacy.
We describe the overall design and architecture, and the key modeling
components, focusing on the unique challenges associated with privacy,
coverage, utility, and consistency. We perform an experimental study in the
context of ads analytics and reporting at LinkedIn, thereby demonstrating the
tradeoffs between privacy and utility needs, and the applicability of
privacy-preserving mechanisms to real-world data. We also highlight the lessons
learned from the production deployment of our system at LinkedIn.Comment: Conference information: ACM International Conference on Information
and Knowledge Management (CIKM 2018
Variational Principle in the Algebra of Asymptotic Fields
This paper proposes a variational principle for the solutions of quantum
field theories in which the ``trial functions'' are chosen from the algebra of
asymptotic fields, and illustrates this variational principle in simple cases.Comment: 15 pages, Latex, no figure
Entanglement and statistics in Hong-Ou-Mandel interferometry
Hong-Ou-Mandel interferometry allows one to detect the presence of
entanglement in two-photon input states. The same result holds for
two-particles input states which obey to Fermionic statistics. In the latter
case however anti-bouncing introduces qualitative differences in the
interferometer response. This effect is analyzed in a Gedankenexperiment where
the particles entering the interferometer are assumed to belong to a
one-parameter family of quons which continuously interpolate between the
Bosonic and Fermionic statistics.Comment: 7 pages, 3 figures; minor editorial changes and new references adde
Non-Pauli Effects from Noncommutative Spacetimes
Noncommutative spacetimes lead to nonlocal quantum field theories (qft's)
where spin-statistics theorems cannot be proved. For this reason, and also
backed by detailed arguments, it has been suggested that they get corrected on
such spacetimes leading to small violations of the Pauli principle. In a recent
paper \cite{Pauli}, Pauli-forbidden transitions from spacetime noncommutativity
were calculated and confronted with experiments. Here we give details of the
computation missing from this paper. The latter was based on a spacetime
different from the Moyal plane. We argue that it
quantizes time in units of . Energy is then conserved only mod
. Issues related to superselection rules raised by non-Pauli
effects are also discussed in a preliminary manner.Comment: 15 Pages, 1 Table, Full details and further developments of
arXiv:1003.2250. This version is close to the one accepted by JHE
A review of the benefits and risks of nonsteroidal anti-inflammatory drugs in the management of mild-to-moderate osteoarthritis
This review is intended to provide physicians with an overview of the benefits and risks associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in the management of their patients with mild-to-moderate osteoarthritis (OA). New information on the inflammatory component of OA and the cardiovascular (CV) risk associated with cyclooxygenase (COX)-2-specific inhibitors has prompted efforts to revise the current recommendations for the use of NSAIDs in the treatment of patients with OA. Clinical studies have shown that naproxen and ibuprofen are significantly more effective at reducing OA pain than is acetaminophen, the traditional first-line therapy, which has no apparent anti-inflammatory activity in the joints. The theoretical advantage of COX-2-specific inhibitors in reducing gastrointestinal (GI) toxicity has been demonstrated by clinical studies. GI complications can be reduced by using lower NSAID doses for the shortest duration or with a concomitant proton-pump inhibitor. All prescription NSAIDs carry a black box warning regarding CV risks; these risks vary among the NSAIDs. While ibuprofen and diclofenac are associated with an increased CV risk, naproxen was associated with a neutral CV risk relative to placebo. Ibuprofen, but not naproxen, attenuates the antiplatelet effects of aspirin. An understanding of the risks and benefits is important when choosing an NSAID. An exhaustive search of the medical literature since 1990 was conducted using the words "ibuprofen," "naproxen," "COX-2-specific NSAIDs," "nonspecific NSAIDs," "low-dose aspirin," and "nonprescription dosage." Databases searched included MEDLINE, EMBASE, and SCISEARCH. This article provides primary care physicians with the information needed to assist them in making more informed decisions in managing patients experiencing mild-to-moderate OA pain
The chameleon groups of Richard J. Thompson: automorphisms and dynamics
The automorphism groups of several of Thompson's countable groups of
piecewise linear homeomorphisms of the line and circle are computed and it is
shown that the outer automorphism groups of these groups are relatively small.
These results can be interpreted as stability results for certain structures of
PL functions on the circle. Machinery is developed to relate the structures on
the circle to corresponding structures on the line
Molecular and mass spectroscopic analysis of isotopically labeled organic residues
Experimental studies aimed at understanding the evolution of complex organic molecules on interstellar grains were performed. The photolysis of frozen gas mixtures of various compositions containing H2O, CO, NH3, and CH4 was studied. These species were chosen because of their astrophysical importance as deducted from observational as well as theoretical studies of ice mantles on interstellar grains. These ultraviolet photolyzed ices were warmed up in order to produce refractory organic molecules like the ones formed in molecular clouds when the icy mantles are being irradiated and warmed up either by a nearby stellar source or impulsive heating. The laboratory studies give estimates of the efficiency of production of such organic material under interstellar conditions. It is shown that the gradual carbonization of organic mantles in the diffuse cloud phase leads to higher and higher visual absorptivity - yellow residues become brown in the laboratory. The obtained results can be applied to explaining the organic components of comets and their relevance to the origin of life
PMH19: IDENTIFICATION AND ONE-YEAR COSTS OF TREATMENT-RESISTANT DEPRESSION IN A CLAIMS DATA ANALYSIS
Müller cell activation, proliferation and migration following laser injury.
PurposeMüller cells are well known for their critical role in normal retinal structure and function, but their reaction to retinal injury and subsequent role in retinal remodeling is less well characterized. In this study we used a mouse model of retinal laser photocoagulation to examine injury-induced Müller glial reaction, and determine how this reaction was related to injury-induced retinal regeneration and cellular repopulation.MethodsExperiments were performed on 3-4-week-old C57BL/6 mice. Retinal laser photocoagulation was used to induce small, circumscribed injuries; these were principally confined to the outer nuclear layer, and surrounded by apparently healthy retinal tissue. Western blotting and immunohistochemical analyses were used to determine the level and location of protein expression. Live cell imaging of green fluorescent protein (GFP)-infected Müller cells (AAV-GFAP-GFP) were used to identify the rate and location of retinal Müller cell nuclear migration.ResultsUpon injury, Müller cells directly at the burn site become reactive, as evidenced by increased expression of the intermediate filament proteins glial fibrillary acidic protein (GFAP) and nestin. These reactive cells re-enter the cell cycle as shown by expression of the markers Cyclin D1 and D3, and their nuclei begin to migrate toward the injury site at a rate of approximately 12 microm/hr. However, unlike other reports, evidence for Müller cell transdifferentiation was not identified in this model.ConclusionsRetinal laser photocoagulation is capable of stimulating a significant glial reaction, marked by activation of cell cycle progression and retinal reorganization, but is not capable of stimulating cellular transdifferentiation or neurogenesis
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