1,534 research outputs found
On the discourse of construction competitiveness
It is contended that competitiveness is better understood as a discourse rather than as a characteristic that is supposedly possessed. The discourse of competitiveness derives its legitimacy from the enterprise culture that came to dominance during the 1980s. Current popularized theories of competitiveness are constituent parts of this broader discourse, which has had significant material implications for the UK construction sector. The dominant discourse of competitiveness amongst contracting firms is shaped by the need to achieve structural flexibility to cope with fluctuations in demand. Fashionable espoused improvement recipes such as total quality management, business process re-engineering, and lean construction legitimize and reinforce the material manifestations of the enterprise culture. In consequence, the UK industry is characterized by a plethora of hollowed-out firms that have failed to invest in their human capital. While the adopted model may be rational for individual firms, the systemic effect across the sector as a whole equates to a form of anorexia. However, the discourse of competitiveness is by no means monolithic and continues to be contested locally. There have also been numerous counter-discourses that have been mobilized in response to the undesirable externalities of unbridled enterprise. Currently, important counter-discourses promote the ideas of sustainability and corporate social responsibility
Characterization of A Type 1 Collagen Targeted PET Tracer
poster abstractRenal fibrosis occurs in many diseases of the kidney, including chronic kidney disease (CKD). Renal fibrosis is characterized by an excessive accumulation and deposition of extracellular matrix components, mainly type I collagen. Determination of the presence and extent of renal fibrosis may aid in the prediction of the long-term outcome of renal function in CKD. Biopsy is considered the gold standard in the diagnosis of renal fibrosis; however biopsy is inherently invasive and does not easily lend itself to following the disease thru time. A noninvasive technique such as PET would both allow the detection and monitoring of renal fibrosis progression. A type I collagen-specific cyclic peptide, EP-3533, has been identified and used as a contrast agent in MRI after conjugation with three Gd-DOTA chelates (Caravan et al 2007). To explore the potential for imaging with PET, which can provide a quantitative assessment of regional peptide localization, we have prepared an EP-3533 conjugate incorporating the NODAGA chelating agent at its amine terminus, and radiolabeled that conjugate with generator-produced positron-emitting 68Ga (68-minute half-life). In vitro association kinetics binding of the labeled peptide was performed in collagen type 1 coated plates, where 68GaDOTA-EP-3533 exhibited a Kd of 0.2 M for type I collagen. To better characterize the tracer in an animal model, renal fibrosis was induced in male Wistar rats by clamping the renal artery and vein of the left kidney for 50 minutes. Thus providing both a diseased and control kidney in each animal. Approximately 10 weeks after surgery both left (fibrotic) and right (normal) kidneys were resected and frozen and mounted in OTC for cryotomy. Longitudinal sections obtained from each kidney were used for autoradiography. ROI analysis found an approximate two- to four-fold region-dependent increase in binding in fibrotic tissue compared to normal. Collagen and non-collagen protein levels were determined in the same kidney sections that had been used for autoradiography using a commercially available staining assay. This assay yielded a 1.7-fold difference in collagen levels between normal and fibrotic tissue. Additionally, representative slices were stained with Sirius Red for histological evaluation. Preliminary data indicates that 68Ga-NODAGA-EP-3533 binds to collagen-rich tissue, consistent with the literature for Gd-DOTA-EP-3533. In vivo studies in an animal model of fibrosis are needed to further characterize this tracer and its potential for PET tracer detection and monitoring of Renal Fibrosis
The magnetic field topology associated to two M flares
On 27 October, 2003, two GOES M-class flares occurred in the lapse of three
hours in active region NOAA 10486. The two flares were confined and their
associated brightenings appeared at the same location, displaying a very
similar shape both at the chromospheric and coronal levels. We focus on the
analysis of magnetic field (SOHO/MDI), chromospheric (HASTA, Kanzelhoehe Solar
Observatory, TRACE) and coronal (TRACE) observations. By combining our data
analysis with a model of the coronal magnetic field, we compute the magnetic
field topology associated to the two M flares. We find that both events can be
explained in terms of a localized magnetic reconnection process occurring at a
coronal magnetic null point. This null point is also present at the same
location one day later, on 28 October, 2003. Magnetic energy release at this
null point was proposed as the origin of a localized event that occurred
independently with a large X17 flare on 28 October, 2003, at 11:01 UT. The
three events, those on 27 October and the one on 28 October, are homologous.
Our results show that coronal null points can be stable topological structures
where energy release via magnetic reconnection can happen, as proposed by
classical magnetic reconnection models.Comment: 14 pages, 7 figure
Viability of primordial black holes as short period gamma-ray bursts
It has been proposed that the short period gamma-ray bursts, which occur at a
rate of , may be evaporating primordial black holes
(PBHs). Calculations of the present PBH evaporation rate have traditionally
assumed that the PBH mass function varies as . This mass
function only arises if the density perturbations from which the PBHs form have
a scale invariant power spectrum. It is now known that for a scale invariant
power spectrum, normalised to COBE on large scales, the PBH density is
completely negligible, so that this mass function is cosmologically irrelevant.
For non-scale-invariant power spectra, if all PBHs which form at given epoch
have a fixed mass then the PBH mass function is sharply peaked around that
mass, whilst if the PBH mass depends on the size of the density perturbation
from which it forms, as is expected when critical phenomena are taken into
account, then the PBH mass function will be far broader than . In this paper we calculate the present day PBH evaporation rate,
using constraints from the diffuse gamma-ray background, for both of these mass
functions. If the PBH mass function has significant finite width, as recent
numerical simulations suggest, then it is not possible to produce a present day
PBH evaporation rate comparable with the observed short period gamma-ray burst
rate. This could also have implications for other attempts to detect
evaporating PBHs.Comment: 5 pages, 2 figures, version to appear in Phys. Rev. D with additional
reference
Classical Open String Models in 4-Dim Minkowski Spacetime
Classical bosonic open string models in fourdimensional Minkowski spacetime
are discussed. A special attention is paid to the choice of edge conditions,
which can follow consistently from the action principle. We consider
lagrangians that can depend on second order derivatives of worldsheet
coordinates. A revised interpretation of the variational problem for such
theories is given. We derive a general form of a boundary term that can be
added to the open string action to control edge conditions and modify
conservation laws. An extended boundary problem for minimal surfaces is
examined. Following the treatment of this model in the geometric approach, we
obtain that classical open string states correspond to solutions of a complex
Liouville equation. In contrast to the Nambu-Goto case, the Liouville potential
is finite and constant at worldsheet boundaries. The phase part of the
potential defines topological sectors of solutions.Comment: 25 pages, LaTeX, preprint TPJU-28-93 (the previous version was
truncated by ftp...
Bounds from Primordial Black Holes with a Near Critical Collapse Initial Mass Function
Recent numerical evidence suggests that a mass spectrum of primordial black
holes (PBHs) is produced as a consequence of near critical gravitational
collapse. Assuming that these holes formed from the initial density
perturbations seeded by inflation, we calculate model independent upper bounds
on the mass variance at the reheating temperature by requiring the mass density
not exceed the critical density and the photon emission not exceed current
diffuse gamma-ray measurements. We then translate these results into bounds on
the spectral index n by utilizing the COBE data to normalize the mass variance
at large scales, assuming a constant power law, then scaling this result to the
reheating temperature. We find that our bounds on n differ substantially
(\delta n > 0.05) from those calculated using initial mass functions derived
under the assumption that the black hole mass is proportional to the horizon
mass at the collapse epoch. We also find a change in the shape of the diffuse
gamma-ray spectrum which results from the Hawking radiation. Finally, we study
the impact of a nonzero cosmological constant and find that the bounds on n are
strengthened considerably if the universe is indeed vacuum-energy dominated
today.Comment: 24 pages, REVTeX, 5 figures; minor typos fixed, two refs added,
version to be published in PR
Electromagnetic transitions of the helium atom in superstrong magnetic fields
We investigate the electromagnetic transition probabilities for the helium
atom embedded in a superstrong magnetic field taking into account the finite
nuclear mass. We address the regime \gamma=100-10000 a.u. studying several
excited states for each symmetry, i.e. for the magnetic quantum numbers
0,-1,-2,-3, positive and negative z parity and singlet and triplet symmetry.
The oscillator strengths as a function of the magnetic field, and in particular
the influence of the finite nuclear mass on the oscillator strengths are shown
and analyzed.Comment: 10 pages, 8 figure
QCD Strings as Constrained Grassmannian Sigma Model:
We present calculations for the effective action of string world sheet in R3
and R4 utilizing its correspondence with the constrained Grassmannian sigma
model. Minimal surfaces describe the dynamics of open strings while harmonic
surfaces describe that of closed strings. The one-loop effective action for
these are calculated with instanton and anti-instanton background, reprsenting
N-string interactions at the tree level. The effective action is found to be
the partition function of a classical modified Coulomb gas in the confining
phase, with a dynamically generated mass gap.Comment: 22 pages, Preprint: SFU HEP-116-9
Minimum mass of galaxies from BEC or scalar field dark matter
Many problems of cold dark matter models such as the cusp problem and the
missing satellite problem can be alleviated, if galactic halo dark matter
particles are ultra-light scalar particles and in Bose-Einstein condensate
(BEC), thanks to a characteristic length scale of the particles. We show that
this finite length scale of the dark matter can also explain the recently
observed common central mass of the Milky Way satellites ()
independent of their luminosity, if the mass of the dark matter particle is
about .Comment: 10 pages, 1 figure, accepted in JCA
Horizon Problem Remediation via Deformed Phase Space
We investigate the effects of a special kind of dynamical deformation between
the momenta of the scalar field of the Brans-Dicke theory and the scale factor
of the FRW metric. This special choice of deformation includes linearly a
deformation parameter. We trace the deformation footprints in the cosmological
equations of motion when the BD coupling parameter goes to infinity. One class
of the solutions gives a constant scale factor in the late time that confirms
the previous result obtained via another approach in the literature. This
effect can be interpreted as a quantum gravity footprint in the coarse grained
explanation. The another class of the solutions removes the big bang
singularity, and the accelerating expansion region has an infinite temporal
range which overcomes the horizon problem. After this epoch, there is a
graceful exiting by which the universe enters in the radiation dominated era.Comment: 13 pages, 2 figures, to appear in GER
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