Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives.

A visible-light-mediated annulation of N-sulfonylallylamines and olefins is reported. Rapid access to highly functionalized chloromethylated pyrrolidines can be achieved using mild conditions for the generation of nitrogen-centered radicals. Both a transition-metal-based catalyst and an organic dye can be used as photosensitizers with 0.5 mol % loading. The reaction was found to be applicable to a large variety of electron-rich and electron-neutral olefins.This work was supported by a postdoctoral fellowship from Pfizer (L.C. and A.G.) and the EPSRC Grants EP/K009494/1 and EP/M004120/1 (S.V.L.)

A distributed wireless MAC scheme for service differentiation in WLANs.

Mobile communications is evolving due to the recent technological achievements in wireless networking. Today, wireless networks exist in many forms, providing different types of services in a range of local, wide area and global coverage. The most widely used WLAN standard today is IEEE 802.11. However, it still has problems with providing the QoS required for multimedia services using distributed methods. In this thesis, a new distributed MAC scheme is proposed to support QoS in wireless LANs. In the scheme, stations use CSMA for channel access, with collisions between stations being resolved by sending a set of beacons in a predefined manner, and virtual collisions being resolved by schedulers at the stations. The proposed MAC scheme is analyzed mathematically, for two-priority case, and the results obtained are validated by simulation. The mathematical model estimates the average delay experienced by data packets of priority one and two under different conditions. A performance evaluation study of the proposed MAC scheme as well as the IEEE 802.11 DCF, and IEEE 802.11e EDCF MAC schemes is also done by means of stochastic simulation. It is found that the results obtained by simulation are in very good agreement with the analytical results, thereby validating them. Moreover, the simulation study evaluated different performance measures of these MAC schemes. The results showed that the IEEE 802.11 DCF scheme does not support QoS, but the proposed MAC scheme and the upcoming IEEE 802.11 EDCF both do. In general, the results show that the proposed MAC scheme performs equally or better than the current IEEE 802.11 DCF scheme in every case considered. It is also found that the proposed MAC scheme performs equally well as the upcoming IEEE 802.11e EDCF scheme, in every case considered in this thesis

Шляхи формування й комплектування джерельних колекцій українських «антикваріїв»

Стаття присвячена дослідженню особливостей формування й комплектування приватних джерельних зібрань українських «антикваріїв» другої половини XVIII – середини XIX ст. на основі аналізу їх наративів

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions

Focal adhesion tyrosine kinase (PTK2) is often overexpressed in human hepatocellular carcinoma (HCC), and several reports have linked PTK2 depletion and/or pharmacological inhibition to reduced tumorigenicity. However, the clinical relevance of targeting PTK2 still remains to be proven. Here, we present two highly selective and functional PTK2 proteolysis-targeting chimeras utilizing von Hippel–Lindau and cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 (cereblon-based) degrades PTK2 with a median DC₅₀ of 30 nM to >80% across a panel of 11 HCC cell lines. Despite effective PTK2 degradation, these compounds did not phenocopy the reported antiproliferative effects of PTK2 depletion in any of the cell lines tested. By disclosing these compounds, we hope to provide valuable tools for the study of PTK2 degradation across different biological systems

First-line tandem high-dose chemotherapy and autologous stem cell transplantation versus single high-dose chemotherapy and autologous stem cell transplantation in multiple myeloma, a systematic review of controlled studies

Several clinical studies have compared single with tandem (also called double) autologous stem cell transplantation (ASCT) as first-line treatment in patients with symptomatic multiple myeloma (MM), one of the leading indications for ASCT worldwide