Roots of Anxiety: The role of cardiovascular regulation and cortisol in the development of anxiety in early adolecence

Since anxiety problems occur frequently, result in considerable suffering and impairment, and tend to persist over time, it is important to investigate putative underlying mechanisms. The aim of the present thesis was to extend the existing knowledge on the aetiology of anxiety by examining the role of two physiological stress response systems, the autonomic nervous system (ANS; consisting of the sympathetic and parasympathetic/vagal branche) and the hypothalamic-pituitaryadrenal (HPA)-axis, in the development of anxiety in early adolescence. The general idea is that some individuals are characterised by increased (re)activity of these two systems; they are more sensitive to stressors than others (so called ‘hyperaroused’). This increased sensitivity might put them at risk for future anxiety problems. In Chapter 1, the theoretical background and the main research questions were presented. The main research questions were: 1) Is anxiety associated with signs of hyperarousal, whereas depression is not? 2) Are high cortisol levels associated with high anxiety levels and is the persistence of anxiety problems associated with high cortisol levels? 3) Do measures of ANS (re)activity predict future anxiety levels, and are such associations different between boys and girls, and specific for anxiety, as apart from depression? 4) Do cortisol measures predict future anxiety levels, and are distinct developmental pathways of anxiety assoc

See the self through others' eyes:The development of moral emotions in young children with autism spectrum disorder

Despite the important social functions of moral emotions, they are understudied in the autism spectrum disorder (ASD) population. This three-wave longitudinal study is among the first to examine the development of moral emotions and their associations with theory of mind in 3- to 7-year-old children with ASD, using observational tasks. One hundred and forty-two children (52 with ASD) were followed over a period of 2 years. We found that while the expressions of shame and guilt remained stable in non-ASD children, they decreased with age in children with ASD. No group differences were found in the levels or the developmental trajectories of pride. Besides, better false-belief understanding was uniquely related to the expressions of pride in children with ASD. Our findings highlight the importance of enhancing understanding of moral emotion development and related factors in children with ASD.</p

'I'm Always on the Lookout for What Could be Going Wrong': Mothers' Concepts and Experiences of Health and Illness in Their Young Children

Mothers in contemporary western societies are expected to adhere to the principles of intensive parenting, spending a great deal of time and effort caring for their children, protecting them from risks and promoting their health, development and wellbeing. This paper draws upon research involving indepth interviews with 60 mothers of infants and young children living in Sydney. The discussion focuses in detail on three major topics discussed in the interviews: how the interviewees conceptualised good health and illness in their children; the role of diet and physical exercise in promoting children’s good health; and space, physical safety and bad influences. The study found that the interviewees reported that they ‘read the signs’ of their children’s bodies and had to ‘know’ their bodies intimately in order to do so. They also interpreted the signals of their own bodies – their ‘gut instincts’ – as part of the process of maintaining careful surveillance of their children’s health state. They represented diet and physical exercise as the most important dimensions of promoting their children’s health, and were very concerned about the risk of obesity in their children. Notions of space and judgements about the bodies within these spaces were also important to some of the women’s concepts of protecting their children’s health and wellbeing.Australian Research Council Discovery Gran

Sex differences in the course of autistic and co-occurring psychopathological symptoms in adolescents with and without autism spectrum disorder

There is an ongoing debate as to whether autism spectrum disorder (ASD) is expressed differently in women than men. It is unclear whether differences found are specific to autism or merely reflecting normative development. In this study, we compared sex differences in developmental trajectories of autistic and co-occurring psychopathological symptoms in adolescents with milder forms of autism to those in a normative group matched for intelligence quotient (IQ) and socioeconomic status. Data of five assessment waves from ages 11 to 22 years were analyzed using linear mixed modeling. We found that in adolescence, sex differences in developmental trajectories of psychopathological symptoms specific for autism are confined to the repetitive stereotyped domain (males had higher scores on the sensory/stereotypic and resistance to change domains, the latter difference disappeared during adolescence due to an increase of these problems in females with ASD). Other sex differences, among which an increase over time in affective and anxiety problems in females was the most outstanding, were also observed in typically developing females. These sex-specific differences have relevance in the clinical care of men and women with autism, although they are subtle compared to differences between individuals with and without autism, which are broadly present in internalizing and externalizing problem domains. </p

Psychometric Properties of the Dutch Contextual Assessment of Social Skills (CASS):An Independent Observational Outcome Measure of Social Skills in Autistic Adolescents

The goal of this study was to translate and adapt the original 9-item of the Contextual Assessment of Social Skills (CASS) to a Dutch version and assess its psychometric qualities. Autistic adolescents aged 12 to 18 years (n = 99) took part in a randomized controlled trial. In this study, pre-intervention data were utilized. The original CASS was adapted to ensure cultural relevance and the content validity was assessed. Data was used to assess reliability and structural validity, using confirmatory factor analysis. 4-item were added to the CASS during the adaptation to better align with the objectives of the experimental intervention. The original 9-item had inter-item correlations between.01 and.70. The Cronbach’s alpha for the original 4-item total score was moderate (α =.69), while for a 7-item total score, it was high (α =.86). This 7-item total score had a sufficient model fit (Comparative Fit Index =.90). This total score had a significant correlation with the Assertion subscale of the Social Skills Improvement System-Adolescent (SSIS-A) (r = 0.26, p &lt;.01), and the Social Responsiveness Scale-2 (SRS-2) total score (r = − .21, p =.04) indicating sufficient convergent validity. The CASS total score was not correlated with the Repetitive and Restricted Behavior scale of the SRS-2 (r = − .08, p =.43), indicating sufficient divergent validity. The Dutch CASS can be considered a conceptually sound and reliable observational instrument for assessing social conversational skills in Dutch autistic youth. Further evaluation of its feasibility when implemented in practice, outside of clinical research, is needed. Trial registration: Dutch trail register NTR6255 (NL6117) 08/02/2017 https://www.trialregister.nl/trial/6117.</p

Reduced autonomic flexibility as a predictor for future anxiety in girls from the general population:The TRAILS study

The present present study investigated whether autonomic flexibility predicted future anxiety levels in adolescent boys and girls. This study is part of the TRacking Adolescents' Individual Lives Survey (TRAILS), a prospective cohort study of Dutch adolescents. The current study included a subsample of 965 individuals. Measures of autonomic flexibility, i.e., heart rate (HR) and respiratory sinus arrhythmia (RSA), were determined during the first assessment wave (T1: participants 10-12 years old). Self-reported anxiety was assessed at the first and second assessment wave (T2: participants 12-14 years old). Possible gender differences and co-occurring depressive problems were examined. In girls, low RSA predicted anxiety levels 2 years later. In boys, no associations between HR and RSA and future anxiety were found. We conclude that in adolescent girls from the general population, signs of reduced autonomic flexibility (i.e., low RSA) predict future anxiety levels. Since the effect size was small, at this point, RSA reactivity alone cannot be used to identify individuals at risk for anxiety, but should be regarded as one factor within a large group of risk factors. However, if the present findings are replicated in clinical studies, intervention programmes - in the future - aimed at normalising autonomic functioning may be helpful. (C) 2009 Elsevier Ireland Ltd. All rights reserved.</p

Urbanicity, biological stress system functioning and mental health in adolescents

Growing up in an urban area has been associated with an increased chance of mental health problems in adults, but less is known about this association in adolescents. We examined whether current urbanicity was associated with mental health problems directly and indirectly via biological stress system functioning. Participants (n = 323) were adolescents from the Dutch general population. Measures included home and laboratory assessments of autonomic nervous system and hypothalamic-pituitary-adrenal axis functioning, neighborhood-level urbanicity and socioeconomic status, and mother- and adolescent self-reported mental health problems. Structural equation models showed that urbanicity was not associated with mental health problems directly. Urbanicity was associated with acute autonomic nervous system and hypothalamic-pituitary-adrenal axis reactivity such that adolescents who lived in more urban areas showed blunted biological stress reactivity. Furthermore, there was some evidence for an indirect effect of urbanicity on mother-reported behavioral problems via acute autonomic nervous system reactivity. Urbanicity was not associated with overall autonomic nervous system and hypothalamic-pituitary-adrenal axis reactivity or basal hypothalamic-pituitary-adrenal axis functioning. Although we observed some evidence for associations between urbanicity, biological stress reactivity and mental health problems, most of the tested associations were not statistically significant. Measures of long-term biological stress system functioning may be more relevant to the study of broader environmental factors such as urbanicity

The specialist predator protects termite colonies from generalist predators

Contains fulltext : 143439.pdf (publisher's version ) (Open Access)BACKGROUND: Children of parents with a substance use disorder (CPSUD) are at increased risk for developing problematic substance use later in life. Endophenotypes may help to clarify the mechanism behind this increased risk. However, substance use and externalizing symptoms may confound the relation between dysregulated physiological stress responding and familial risk for substance use disorders (SUDs). METHODS: We examined whether heart rate (HR) responses differed between CPSUDs and controls. Participants (aged 11-20years) were CPSUDs (N=75) and controls (N=363), semi-matched on the basis of sex, socioeconomic status, and ethnicity. HR was measured continuously during a psychosocial stress procedure. Substance use and externalizing symptoms were self-reported and mother-reported, respectively. RESULTS: A piecewise, mixed-effects model was fit for HR across the stress procedure, with fixed effects for HR reactivity and HR recovery. CPSUDs showed a blunted HR recovery. CPSUDs reported drinking more frequently, were more likely to use tobacco daily, were more likely to report ever use of cannabis and used cannabis more frequently, and exhibited more externalizing symptoms. These variables did not confound the relation between familial risk for SUDs and a blunted HR recovery. CONCLUSION: Our findings suggest dysregulated autonomic nervous system (ANS) responding in CPSUDs and contribute to the accumulating evidence for ANS dysregulation as a potential endophenotype for SUDs.9 p