Robust low loss splicing of hollow core photonic bandgap fiber to itself

Robust, low loss (0.16dB) splicing of hollow core photonic band gap fiber to itself is presented. Modal content is negligibly affected by splicing, enabling penalty-free 40Gbit/s data transmission over > 200m of spliced PBGF

Whole-cell analysis of low-density lipoprotein uptake by macrophages using STEM tomography

Nanoparticles of heavy materials such as gold can be used as markers in quantitative electron microscopic studies of protein distributions in cells with nanometer spatial resolution. Studying nanoparticles within the context of cells is also relevant for nanotoxicological research. Here, we report a method to quantify the locations and the number of nanoparticles, and of clusters of nanoparticles inside whole eukaryotic cells in three dimensions using scanning transmission electron microscopy (STEM) tomography. Whole-mount fixed cellular samples were prepared, avoiding sectioning or slicing. The level of membrane staining was kept much lower than is common practice in transmission electron microscopy (TEM), such that the nanoparticles could be detected throughout the entire cellular thickness. Tilt-series were recorded with a limited tilt-range of 80u thereby preventing excessive beam broadening occurring at higher tilt angles. The 3D locations of the nanoparticles were nevertheless determined with high precision using computation. The obtained information differed from that obtained with conventional TEM tomography data since the nanoparticles were highlighted while only faint contrast was obtained on the cellular material. Similar as in fluorescence microscopy, a particular set of labels can be studied. This method was applied to study the fate of sequentially up-taken low-density lipoprotein (LDL) conjugated to gold nanoparticles in macrophages. Analysis of a 3D reconstruction revealed that newly up-taken LDL-gold was delivered to lysosomes containing previously up-taken LDL-gold thereby forming onion-like clusters

The Geometry of D=11 Killing Spinors

We propose a way to classify all supersymmetric configurations of D=11 supergravity using the G-structures defined by the Killing spinors. We show that the most general bosonic geometries admitting a Killing spinor have at least a local SU(5) or an (Spin(7)\ltimes R^8)x R structure, depending on whether the Killing vector constructed from the Killing spinor is timelike or null, respectively. In the former case we determine what kind of local SU(5) structure is present and show that almost all of the form of the geometry is determined by the structure. We also deduce what further conditions must be imposed in order that the equations of motion are satisfied. We illustrate the formalism with some known solutions and also present some new solutions including a rotating generalisation of the resolved membrane solutions and generalisations of the recently constructed D=11 Godel solution.Comment: 36 pages. Typos corrected and discussion on G-structures improved. Final version to appear in JHE

M-theory on eight-manifolds revisited: N=1 supersymmetry and generalized Spin(7) structures

The requirement of ${\cal N}=1$ supersymmetry for M-theory backgrounds of the form of a warped product ${\cal M}\times_{w}X$, where $X$ is an eight-manifold and ${\cal M}$ is three-dimensional Minkowski or AdS space, implies the existence of a nowhere-vanishing Majorana spinor $\xi$ on $X$. $\xi$ lifts to a nowhere-vanishing spinor on the auxiliary nine-manifold $Y:=X\times S^1$, where $S^1$ is a circle of constant radius, implying the reduction of the structure group of $Y$ to $Spin(7)$. In general, however, there is no reduction of the structure group of $X$ itself. This situation can be described in the language of generalized $Spin(7)$ structures, defined in terms of certain spinors of $Spin(TY\oplus T^*Y)$. We express the condition for ${\cal N}=1$ supersymmetry in terms of differential equations for these spinors. In an equivalent formulation, working locally in the vicinity of any point in $X$ in terms of a `preferred' $Spin(7)$ structure, we show that the requirement of ${\cal N}=1$ supersymmetry amounts to solving for the intrinsic torsion and all irreducible flux components, except for the one lying in the $\bf{27}$ of $Spin(7)$, in terms of the warp factor and a one-form $L$ on $X$ (not necessarily nowhere-vanishing) constructed as a $\xi$ bilinear; in addition, $L$ is constrained to satisfy a pair of differential equations. The formalism based on the group $Spin(7)$ is the most suitable language in which to describe supersymmetric compactifications on eight-manifolds of $Spin(7)$ structure, and/or small-flux perturbations around supersymmetric compactifications on manifolds of $Spin(7)$ holonomy.Comment: 24 pages. V2: introduction slightly extended, typos corrected in the text, references added. V3: the role of Spin(7) clarified, erroneous statements thereof corrected. New material on generalized Spin(7) structures in nine dimensions. To appear in JHE

Subthreshold dynamics of the neural membrane potential driven by stochastic synaptic input

In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of the background activity and of the synapses made on a neuron. Subthreshold membrane polarization is, in turn, a potent modulator of neural responses. The present paper analyzes the subthreshold dynamics of the neural membrane potential driven by synaptic inputs of stationary statistics. Synaptic inputs are considered in linear interaction. The analysis identifies regimes of input statistics which give rise to stationary, fluctuating, oscillatory, and unstable dynamics. In particular, I show that (i) mere noise inputs can drive the membrane potential into sustained, quasiperiodic oscillations (noise-driven oscillations), in the absence of a stimulus-derived, intraneural, or network pacemaker; (ii) adding hyperpolarizing to depolarizing synaptic input can increase neural activity (hyperpolarization-induced activity), in the absence of hyperpolarization-activated currents

Superstrings with Intrinsic Torsion

We systematically analyse the necessary and sufficient conditions for the preservation of supersymmetry for bosonic geometries of the form R^{1,9-d} \times M_d, in the common NS-NS sector of type II string theory and also type I/heterotic string theory. The results are phrased in terms of the intrinsic torsion of G-structures and provide a comprehensive classification of static supersymmetric backgrounds in these theories. Generalised calibrations naturally appear since the geometries always admit NS or type I/heterotic fivebranes wrapping calibrated cycles. Some new solutions are presented. In particular we find d=6 examples with a fibred structure which preserve N=1,2,3 supersymmetry in type II and include compact type I/heterotic geometries.Comment: 58 pages, LaTeX; v2: New section on solutions including an example with N=3 supersymmetry and discussion of heterotic compactifications. Details on conventions and references added. v3: added an explicit example of non-integrable product structure in Appendix C; some typos fixe

Globally Anisotropic High Porosity Silica Aerogels

We discuss two methods by which high porosity silica aerogels can be engineered to exhibit global anisotropy. First, anisotropy can be introduced with axial strain. In addition, intrinsic anisotropy can result during growth and drying stages and, suitably controlled, it can be correlated with preferential radial shrinkage in cylindrical samples. We have performed small angle X-ray scattering (SAXS) to characterize these two types of anisotropy. We show that global anisotropy originating from either strain or shrinkage leads to optical birefringence and that optical cross-polarization studies are a useful characterization of the uniformity of the imposed global anisotropy.Comment: 18 pages, 14 figures, submitted to Journal of Non-Crystalline Solid

The association between driving time and unhealthy lifestyles: a cross-sectional, general population study of 386 493 UK Biobank participants

Background: Driving is a common type of sedentary behaviour; an independent risk factor for poor health. The study explores whether driving is also associated with other unhealthy lifestyle factors. Methods: In a cross-sectional study of UK Biobank participants, driving time was treated as an ordinal variable and other lifestyle factors dichotomized into low/high risk based on guidelines. The associations were explored using chi-square tests for trend and binary logistic regression. Results: Of the 386 493 participants who drove, 153 717 (39.8%) drove <1 h/day; 140 140 (36.3%) 1 h/day; 60 973 (15.8%) 2 h/day; and 31 663 (8.2%) ≥3 h/day. Following adjustment for potential confounders, driving ≥3 h/day was associated with being overweight/obese (OR = 1.74, 95% CI: 1.64–1.85), smoking (OR = 1.48, 95% CI: 1.37–1.63), insufficient sleep (1.70, 95% CI: 1.61–1.80), low fruit/vegetable intake (OR = 1.26, 95% CI: 1.18–1.35) and low physical activity (OR = 1.05, 95% CI: 1.00–1.11), with dose relationships for the first three, but was not associated with higher alcohol consumption (OR = 0.94, 95% CI: 0.87–1.02). Conclusions: Sedentary behaviour, such as driving, is known to have an independent association with adverse health outcomes. It may have additional impact mediated through its effect on other aspects of lifestyle. People with long driving times are at higher risk and might benefit from targeted interventions

Metastable supergravity vacua with F and D supersymmetry breaking

We study the conditions under which a generic supergravity model involving chiral and vector multiplets can admit viable metastable vacua with spontaneously broken supersymmetry and realistic cosmological constant. To do so, we impose that on the vacuum the scalar potential and all its first derivatives vanish, and derive a necessary condition for the matrix of its second derivatives to be positive definite. We study then the constraints set by the combination of the flatness condition needed for the tuning of the cosmological constant and the stability condition that is necessary to avoid unstable modes. We find that the existence of such a viable vacuum implies a condition involving the curvature tensor for the scalar geometry and the charge and mass matrices for the vector fields. Moreover, for given curvature, charges and masses satisfying this constraint, the vector of F and D auxiliary fields defining the Goldstino direction is constrained to lie within a certain domain. The effect of vector multiplets relative to chiral multiplets is maximal when the masses of the vector fields are comparable to the gravitino mass. When the masses are instead much larger or much smaller than the gravitino mass, the effect becomes small and translates into a correction to the effective curvature. We finally apply our results to some simple classes of examples, to illustrate their relevance.Comment: 40 pages; v2 some clarifications added in the introduction; v3 some typos correcte

Chemical telemetry of OH observed to measure interstellar magnetic fields

We present models for the chemistry in gas moving towards the ionization front of an HII region. When it is far from the ionization front, the gas is highly depleted of elements more massive than helium. However, as it approaches the ionization front, ices are destroyed and species formed on the grain surfaces are injected into the gas phase. Photodissociation removes gas phase molecular species as the gas flows towards the ionization front. We identify models for which the OH column densities are comparable to those measured in observations undertaken to study the magnetic fields in star forming regions and give results for the column densities of other species that should be abundant if the observed OH arises through a combination of the liberation of H2O from surfaces and photodissociation. They include CH3OH, H2CO, and H2S. Observations of these other species may help establish the nature of the OH spatial distribution in the clouds, which is important for the interpretation of the magnetic field results.Comment: 11 pages, 2 figures, accepted by Astrophysics and Space Scienc