Harmonically mode-locked fibre soliton lasers and their applications

We present a detailed description of a passive harmonically mode-locked laser. Experimental results are consistent with the suggestion of a passive self-stabilization effect driven by transverse acoustic wave excitation due to electrostriction. We also demonstrate some applications of the laser

Siphonochilus aethiopicus (Zingiberaceae): observations on floral and reproductive biology

A taxonomic revision for the Flora of Southern Africa of Siphonochilus (Zingiberaceae) awaits publication (R.M. Smith, RBG, Edin., pers. comm. to ABC, 1987). In this revision the two southern African species, S. aethiopicus (Schweinf.) B.L. Burtt and S. natalensis (Schltr. & Schum.) Wood & Franks will be united. For the purposes of this article this conspecificity is assumed. S. aethiopicus has a distribution in Africa southwards from Senegal and Ethiopia to the Transvaal. Futher south wild populations are not now known, the species having disappeared from the natural flora of Natal. Rhizomes are extensively used in traditional African medicine and cultural practices. Floral and reproductive biology is poorly documented, but important if cultivated stocks in southern Africa are to be maintained. Monitoring of plants under cultivation and semi-natural conditions did not support the record of polygamy within the species. One type of flower only was produced by an individual rhizome. Bisexual flowers may mature to fruits containing viable seed that will germinate in situ. Ovaries of female flowers did not develop, suggesting apomixis does not operate in seed production. The internal surfaces of the staminodial tubes of bisexual flowers bore scattered glandular trichomes; those of female flowers densely placed multicellular papillae. Bisexual and female flowers are thus strikingly different in detailed structure as well as in general morphological form

Passive harmonic mode-locking in soliton fibre lasers

We present an experimental and theoretical study of passively mode-locked fibre soliton lasers. Our theoretical analysis based on perturbation theory describes the soliton interactions which occur when pulse bunches form. Our results indicate that the non-soliton component emitted by the propagating solitons causes small changes of the central frequency of individual solitons and the strength and sign of this interaction between the soliton and dispersive waves depends on their mutual phase as well as on the soliton position within the soliton bunch. For a certain phase difference between the solitons and non-soliton component the interaction force becomes repulsive for all solitons within a soliton bunch and results in an almost uniform distribution of the pulses inside the laser cavity. The pulses are then locked in their temporal positions by acoustic effects. We also demonstrate that the laser performance could be further improved by the use of a MQW saturable absorber in combination with the nonlinear amplifying loop mirror. In this instance the MQW sample acts not only as a fast saturable absorber but also as a passive phase modulator. We experimentally demonstrate that such a laser is capable of generating 500 fs pulses at repetition rates exceeding 2 GHz

Femtosecond harmonically mode-locked fibre laser with time jitter below 1ps

We have made an experimental study of the time jitter in a harmonic passively mode-locked fiber soliton ring laser. We demonstrate that jitter as low as 600 fs (100-550 Hz), which is less than the soliton pulse width, can be achieved at a repetition frequency of 463 MHz. The results support the suggestion that the stability of the laser is dependent on the long-range soliton interaction through the excitation of acoustic waves that is induced by the propagating pulses

Reduction of soliton instability in transmission systems by means of chirped bandwidth-limited amplification

We demonstrate both numerically and experimentally that soliton instability is substantially reduced in a system employing spectral filtering and chirped amplification. In such a system, 5 ps solitons remain stable over practically unlimited distance with the amplification period increased up to 3 dispersion lengths

Soliton compression in a nonlinear amplifying loop mirror

We have experimentally demonstrated the ability of the NALM to compress solitons with a low fraction of non-soliton component. The principle of operation of an all-fibre tunable source of femtosecond pulses has been shown

Regulation of ciliated cell differentiation in cultures of rat tracheal epithelial cells.

The cellular pathway of ciliated cell differentiation and its regulation is poorly defined. To begin to understand the process of ciliated cell differentiation, we sought to identify factors regulating ciliated cell development in vitro. Rat tracheal epithelial (RTE) cells were cultured on collagen gel-coated membranes at an air-liquid interface in hormone- and growth factor-supplemented medium (complete medium [CM]). Under these conditions, RTE cells first proliferate and then differentiate into a pseudostratified mucociliary epithelium. Ciliated cell differentiation was measured using a monoclonal antibody, RTE3, which was shown to specifically react with the plasma membrane of ciliated cells. Cultures were immunostained in situ, and the percentage of the culture surface covered with ciliated cells was estimated using videomicroscopy and an image analysis program. If an air-liquid interface was not created and the cells were maintained in the submerged state, ciliated cell differentiation was suppressed 25-fold. Culture in the absence of mitogenic components present in CM, including epidermal growth factor (EGF), cholera toxin (CT), or bovine pituitary extract, resulted in 2- to 4-fold increases in the percentage of ciliated cells. When both EGF and CT were removed from the media, DNA synthesis and total cell number was reduced, while ciliated cell differentiation increased as much as 5-fold. These results demonstrate that submersion inhibits, while withdrawal of mitogenic compounds promotes, ciliated cell differentiation in vitro

Adjusting for treatment switching in oncology trials: A systematic review and recommendations for reporting

Objectives To systematically review the quality of reporting on the application of switching adjustment approaches in published oncology trials and industry submissions to the National Institute for Health and Care Excellence Although methods such as the rank preserving structural failure time model (RPSFTM) and inverse probability of censoring weights (IPCW) have been developed to address treatment switching, the approaches are not widely accepted within health technology assessment. This limited acceptance may partly be a consequence of poor reporting on their application. Methods Published trials and industry submissions were obtained from searches of PubMed and nice.org.uk, respectively. The quality of reporting in these studies was judged against a checklist of reporting recommendations, which was developed by the authors based on detailed considerations of the methods. Results Thirteen published trials and 8 submissions to nice.org.uk satisfied inclusion criteria. The quality of reporting around the implementation of the RPSFTM and IPCW methods was generally poor. Few studies stated whether the adjustment approach was prespecified, more than a third failed to provide any justification for the chosen method, and nearly half neglected to perform sensitivity analyses. Further, it was often unclear how the RPSFTM and IPCW methods were implemented. Conclusions Inadequate reporting on the application of switching adjustment methods increases uncertainty around results, which may contribute to the limited acceptance of these methods by decision makers. The proposed reporting recommendations aim to support the improved interpretation of analyses undertaken to adjust for treatment switching

Estimates of marker effects for measures of milk flow in the Italian brown Swiss dairy cattle population

Background: Milkability is a complex trait that is characterized by milk flow traits including average milk flow rate, maximum milk flow rate and total milking time. Milkability has long been recognized as an economically important trait that can be improved through selection. By improving milkability, management costs of milking decrease through reduced labor and improved efficiency of the automatic milking system, which has been identified as an important factor affecting net profit. The objective of this study was to identify markers associated with electronically measured milk flow traits, in the Italian Brown Swiss population that could potentially improve selection based on genomic predictions.Results: Sires (n = 1351) of cows with milk flow information were genotyped for 33,074 single nucleotide polymorphism (SNP) markers distributed across 29 Bos taurus autosomes (BTA). Among the six milk flow traits collected, ascending time, time of plateau, descending time, total milking time, maximum milk flow and average milk flow, there were 6,929 (time of plateau) to 14,585 (maximum milk flow) significant SNP markers identified for each trait across all BTA. Unique regions were found for each of the 6 traits providing evidence that each individual milk flow trait offers distinct genetic information about milk flow. This study was also successful in identifying functional processes and genes associated with SNPs that influences milk flow.Conclusions: In addition to verifying the presence of previously identified milking speed quantitative trait loci (QTL) within the Italian Brown Swiss population, this study revealed a number of genomic regions associated with milk flow traits that have never been reported as milking speed QTL. While several of these regions were not associated with a known gene or QTL, a number of regions were associated with QTL that have been formerly reported as regions associated with somatic cell count, somatic cell score and udder morphometrics. This provides further evidence of the complexity of milk flow traits and the underlying relationship it has with other economically important traits for dairy cattle. Improved understanding of the overall milking pattern will aid in identification of cows with lower management costs and improved udder health

On the complete classification of the unitary N=2 minimal superconformal field theories

Aiming at a complete classification of unitary N=2 minimal models (where the assumption of space-time supersymmetry has been dropped), it is shown that each modular invariant candidate of a partition function for such a theory is indeed the partition function of a minimal model. A family of models constructed via orbifoldings of either the diagonal model or of the space-time supersymmetric exceptional models demonstrates that there exists a unitary N=2 minimal model for every one of the allowed partition functions in the list obtained from Gannon's work. Kreuzer and Schellekens' conjecture that all simple current invariants can be obtained as orbifolds of the diagonal model, even when the extra assumption of higher-genus modular invariance is dropped, is confirmed in the case of the unitary N=2 minimal models by simple counting arguments.Comment: 53 pages; Latex; minor changes in v2: intro expanded, references added, typos corrected, footnote added on p31; renumbering of sections; main theorem reformulated for clarity, but contents unchanged. Minor revisions in v3: typos corrected, footnotes 5, 6 added, lemma 1 and section 3.3.2 rewritten for greater generality, section 3.3 review removed. To appear in Comm. Math. Phy