Identification of paper by stationary phase performance

Paper is an extraordinary example of a composite engineering material with practical use in a huge variety of applications. Since its invention in China there have been many alterations to manufacturing techniques, component formulation and surface finishing, but the essential characteristics of the product have not changed greatly. The objective of this experiment is to demonstrate that the chromatographic performance of paper as a stationary phase may be used to distinguish between externally-similar materials. The procedure developed is so simple that even students with little exposure to practical chemistry and limited chemical knowledge can understand the essential content. Because of the ubiquitous nature of paper, it is often recovered from crime scenes as evidence for analysis. However, the variety of sources and the mechanical or chemical properties often make demonstration of unequivocal correlation between “questioned” and “known” or “reference” samples a complex task. Introducing the practical session as a crime scene investigation, and presenting the laboratory exercise as an accessible forensic technique for paper identification, adds an exciting dimension to the practical experience for young people.Centro de Química (FEDER-COMPETE/QREN/EU and PEst C/QUI/U1686/2013, Fundação para a Ciência e Tecnologia)

The polar Catalysmic Variable 1RXS J173006.4+033813

We report the discovery of 1RXS J173006.4+033813, a polar cataclysmic variable with a period of 120.21 min. The white dwarf primary has a magnetic field of B = 42+6-5 MG, and the secondary is a M3 dwarf. The system shows highly symmetric double peaked photometric modulation in the active state as well as in quiescence. These arise from a combination of cyclotron beaming and ellipsoidal modulation. The projected orbital velocity of the secondary is K2 = 390+-4 km/s. We place an upper limit of 830+-65 pc on the distance.Comment: ApJ Accepted. 12 Pages, 13 Figures, 6 table

Game of Stones:feasibility randomised controlled trial of how to engage men with obesity in text message and incentive interventions for weight loss

Objectives To examine the acceptability and feasibility of narrative text messages with or without financial incentives to support weight loss for men. Design Individually randomised three-arm feasibility trial with 12 months’ follow-up. Setting Two sites in Scotland with high levels of disadvantage according to Scottish Index for Multiple Deprivation (SIMD). Participants Men with obesity (n=105) recruited through community outreach and general practitioner registers. Interventions Participants randomised to: (A) narrative text messages plus financial incentive for 12 months (short message service (SMS)+I), (B) narrative text messages for 12 months (SMS only), or (C) waiting list control. Outcomes Acceptability and feasibility of recruitment, retention, intervention components and trial procedures assessed by analysing quantitative and qualitative data at 3, 6 and 12 months. Results 105 men were recruited, 60% from more disadvantaged areas (SIMD quintiles 1 or 2). Retention at 12 months was 74%. Fewer SMS+I participants (64%) completed 12-month assessments compared with SMS only (79%) and control (83%). Narrative texts were acceptable to many men, but some reported negative reactions. No evidence emerged that level of disadvantage was related to acceptability of narrative texts. Eleven SMS+I participants (31%) successfully met or partially met weight loss targets. The cost of the incentive per participant was £81.94 (95% CI £34.59 to £129.30). Incentives were acceptable, but improving health was reported as the key motivator for weight loss. All groups lost weight (SMS+I: −2.51 kg (SD=4.94); SMS only: −1.29 kg (SD=5.03); control: −0.86 kg (SD=5.64) at 12 months). Conclusions This three-arm weight management feasibility trial recruited and retained men from across the socioeconomic spectrum, with the majority from areas of disadvantage, was broadly acceptable to most participants and feasible to deliver

A Framework for Methodological Choice and Evidence Assessment for Studies Using External Comparators from Real-World Data.

Several approaches have been proposed recently to accelerate the pathway from drug discovery to patient access. These include novel designs such as using controls external to the clinical trial where standard randomised controls are not feasible. In parallel, there has been rapid growth in the application of routinely collected healthcare 'real-world' data for post-market safety and effectiveness studies. Thus, using real-world data to establish an external comparator arm in clinical trials is a natural next step. Regulatory authorities have begun to endorse the use of external comparators in certain circumstances, with some positive outcomes for new drug approvals. Given the potential to introduce bias associated with observational studies, there is a need for recommendations on how external comparators should be best used. In this article, we propose an evaluation framework for real-world data external comparator studies that enables full assessment of available evidence and related bias. We define the principle of exchangeability and discuss the applicability of criteria described by Pocock for consideration of the exchangeability of the external and trial populations. We explore how trial designs using real-world data external comparators fit within the evidence hierarchy and propose a four-step process for good conduct of external comparator studies. This process is intended to maximise the quality of evidence based on careful study design and the combination of covariate balancing, bias analysis and combining outcomes

Protocol for a Mixed-Method Investigation of the Impact of the COVID-19 Pandemic and Gambling Practices, Experiences and Marketing in the UK:The "Betting and Gaming COVID-19 Impact Study"

The COVID-19 pandemic led to unprecedented restrictions on people’s movements and interactions, as well as the cancellation of major sports events and social activities, directly altering the gambling landscape. There is urgent need to provide regulators, policy makers and treatment providers with evidence on the patterns and context of gambling during COVID-19 and its aftermath. This protocol describes a study addressing the following three questions: (1) How has COVID-19 changed gambling practices and the risk factors for, and experience of, gambling harms? (2) What is the effect of COVID-19 on gambling marketing? (3) How has COVID-19 changed high risk groups’ gambling experiences and practices? This mixed-method study focuses on two groups, namely young adults and sports bettors. In workpackage-1, we will extend an existing longitudinal survey of gambling in young adults (aged 16–24 years) (first wave conducted June–August 2019), adding COVID-19-related questions to the second wave (July–August 2020) and extending to a third wave in 2021; and undertake a survey of sports bettors in the UK (baseline n = 4000, ~July–August 2020), with follow-ups in ~October–November 2020 and ~February-March 2021. In workpackage-2, we will examine changes in expenditure on paid-for gambling advertising from January 2019 to July 2021 and undertake a mixed-method content analysis of a random sample of paid-for gambling advertising (n ~ 200) and social media marketing (n ~ 100) during the initial COVID-19 “lockdown”. Workpackage-3 will involve qualitative interviews with a purposive sample of (a) young adults (aged 18–24 years) and (b) sports bettors

The effectiveness of the 13-valent pneumococcal conjugate vaccine against hypoxic pneumonia in children in Lao People's Democratic Republic: An observational hospital-based test-negative study

Background: Pneumococcal pneumonia is a leading cause of childhood mortality. Pneumococcal conjugate vaccines (PCVs) have been shown to reduce hypoxic pneumonia in children. However, there are no studies from Asia examining the effectiveness of PCVs on hypoxic pneumonia. We describe a novel approach to determine the effectiveness of the 13-valent PCV (PCV13) against hypoxia in children admitted with pneumonia in the Lao People's Democratic Republic. Methods: A prospective hospital-based, test-negative observational study of children aged up to 59 months admitted with pneumonia to a single tertiary hospital in Vientiane was undertaken over 54 months. Pneumonia was defined using the 2013 WHO definition. Hypoxia was defined as oxygen saturation <90% in room air or requiring oxygen supplementation during hospitalisation. Test-negative cases and controls were children with hypoxic and non-hypoxic pneumonia, respectively. PCV13 status was determined by written record. Vaccine effectiveness was calculated using logistic regression. Propensity score and multiple imputation analyses were used to handle confounding and missing data. Findings: There were 826 children admitted with pneumonia, 285 had hypoxic pneumonia and 377 were PCV13-vaccinated. The unadjusted, propensity-score adjusted and multiple-imputation adjusted estimates of vaccine effectiveness against hypoxic pneumonia were 23% (95% confidence interval: -9, 46%; p=0•14); 37% (6, 57%; p=0•02) and 35% (7, 55%; p=0•02) respectively. Interpretation: PCV13 is effective against hypoxic pneumonia in Asia, and should be prioritised for inclusion in national immunisation programs. This single hospital-based, test-negative approach can be used to assess vaccine effectiveness in other similar settings. Funding: Funded by the Bill & Melinda Gates Foundation

The transition into adoptive parenthood: adoption as a process of continued unsafe uncertainty when family scripts collide

Our prospective study investigated couples’ expectations of adoptive parenthood and explored how these changed with their actual experience of parenthood. Six heterosexual couples were interviewed just before placement began and six months after the children had arrived. Interpretative Phenomenological Analysis (IPA) was used to analyse both sets of interview data. Expectations of adoptive parenthood mostly transformed smoothly into adoption experience for couples but challenges were experienced when family scripts collided and a continued feeling of unsafe uncertainty then prevailed within these newly formed family systems. Family script collision seemed a particular problem for couples adopting sibling pairs. To further professional practice in working with families over the transition to adoptive parenting we suggest that professionals keep in mind a framework that includes: Internal and external world influences on family members, Intergenerational issues, Family scripts, and the Structural challenges of adoption (IIFS)

Text messaging and financial incentives to encourage weight loss in men with obesity: the Game of Stones feasibility RCT

Funding: This project was funded by the National Institute for Health Research (NIHR) Public Health Research programme and will be published in full in Public Health Research; Vol. 8, No. 11. See the NIHR Journals Library website for further project information.Peer reviewedPublisher PD

Meaningful informed consent with young children: looking forward through an interactive narrative approach

Ideas about ethical research with young children are evolving at a rapid rate. Not only can young children participate in the informed consent process, but researchers now also recognize that the process must be meaningful for them. As part of a larger study, this article reviews children's rights and informed consent literature as the foundation for the development of a new conceptual model of meaningful early childhood informed consent. Based on this model, an ‘interactive narrative’ approach is presented as a means to inform three- to eight-year-old children about what their participation might involve and to assist them to understand and respond as research participants. For use with small groups, this approach revolves around a storybook based on research-related factual images delivered via interactive (re)telling. This narrative approach to informed consent is unique in its holistic design which seeks to address the specific needs of young children in research

Post-marital residence patterns show lineage-specific evolution

Where a newly-married couple lives, termed post-marital residence, varies cross-culturally and changes over time. While many factors have been proposed as drivers of this change, among them general features of human societies like warfare, migration and gendered division of subsistence labour, little is known about whether changes in residence patterns exhibit global regularities. Here, we study ethnographic observations of post-marital residence in societies from five large language families (Austronesian, Bantu, Indo-European, Pama-Nyungan and Uto-Aztecan), encompassing 371 ethnolinguistic groups ranging widely in local ecologies and lifeways, and covering over half the worlds population and geographical area. We apply Bayesian comparative methods to test the hypothesis that post-marital residence patterns have evolved in similar ways across different geographical regions. By reconstructing past post-marital residence states, we compare transition rates and models of evolution across groups, while integrating the historical descent relationships of human societies. We find that each language family possesses its own best fitting model, demonstrating that the mode and pace of post-marital residence evolution is lineage-specific rather than global.We thank Laura Fortunato (Institute of Cognitive and Evolutionary Anthropology, University of Oxford, UK) and Kit Opie (Department of Anthropology, University College London, UK) for access to analyses from their published work; Lyle Campbell (Department of Linguistics, University of Hawai’i Manoa, USA) and Jane Hill (School of Anthropology, University of Arizona, USA) for cognancy coding in the Uto-Aztecan dataset; and Eilis Donnelly (Victoria University of Wellington) for assistance with summarizing the ethnographic literature of Uto-Aztecan and Pama-Nyungan speakers. This research was supported by the Royal Society of New Zealand through a Rutherford Fellowship (RDF-10-MAU-001) to M.P.C., by an Allan Wilson Centre for Molecular Ecology and Evolution grant to M.P.C. and R.G., and by an Alexander von Humboldt Stiftung fellowship to M.P.C. The Max Planck Institute for the Science of Human History funded J.C.M. to attend its 2016 Spring School on quantitative methods for studying linguistic and cultural evolution. S.M. and M.P.C. are partially supported by the New Zealand Centre of Research Excellence Te Pūnaha Matatini. R.M.R. was supported by a grant from the European Union Horizon 2020 Research and Innovation Programme (grant agreement No 644055 [ALIGNED, http://aligned-project.eu]). F.M.J. received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement No 639291, Starting Grant VARIKIN), and was supported by a Leverhulme Research Fellowship (47690)