Self-cooling of a movable mirror to the ground state using radiation pressure

We show that one can cool a micro-mechanical oscillator to its quantum ground state using radiation pressure in an appropriately detuned cavity (self-cooling). From a simple theory based on Heisenberg-Langevin equations we find that optimal self-cooling occurs in the good cavity regime, when the cavity bandwidth is smaller than the mechanical frequency, but still larger than the effective mechanical damping. In this case the intracavity field and the vibrational mechanical mode coherently exchange their fluctuations. We also present dynamical calculations which show how to access the mirror final temperature from the fluctuations of the field reflected by the cavity.Comment: 4 pages, 3 figure

Quantum noise in ideal operational amplifiers

We consider a model of quantum measurement built on an ideal operational amplifier operating in the limit of infinite gain, infinite input impedance and null output impedance and with a feddback loop. We evaluate the intensity and voltage noises which have to be added to the classical amplification equations in order to fulfill the requirements of quantum mechanics. We give a description of this measurement device as a quantum network scattering quantum fluctuations from input to output ports.Comment: 4 pages, 2 figures, RevTe

Endoscopic management of gastrointestinal leaks and fistulae: What option do we have?

Gastrointestinal leaks and fistulae are serious, potentially life threatening conditions that may occur with a wide variety of clinical presentations. Leaks are mostly related to post-operative anastomotic defects and are responsible for an important share of surgical morbidity and mortality. Chronic leaks and long standing post-operative collections may evolve in a fistula between two epithelialized structures. Endoscopy has earned a pivotal role in the management of gastrointestinal defects both as first line and as rescue treatment. Endotherapy is a minimally invasive, effective approach with lower morbidity and mortality compared to revisional surgery. Clips and luminal stents are the pioneer of gastrointestinal (GI) defect endotherapy, whereas innovative endoscopic closure devices and techniques, such as endoscopic internal drainage, suturing system and vacuum therapy, has broadened the indications of endoscopy for the management of GI wall defect. Although several endoscopic options are currently used, a standardized evidence-based algorithm for management of GI defect is not available. Successful management of gastrointestinal leaks and fistulae requires a tailored and multidisciplinary approach based on clinical presentation, defect features (size, location and onset time), local expertise and the availability of devices. In this review, we analyze different endoscopic approaches, which we selected on the basis of the available literature and our own experience. Then, we evaluate the overall efficacy and procedural-specific strengths and weaknesses of each approach

Foam front propagation in anisotropic oil reservoirs

The pressure-driven growth model is considered, describing the motion of a foam front through an oil reservoir during foam improved oil recovery, foam being formed as gas advances into an initially liquid-filled reservoir. In the model, the foam front is represented by a set of so called ‘material points’ that track the advance of gas into the liquid-filled region. According to the model, the shape of the foam front is prone to develop concave sharply-curved concavities, where the orientation of the front changes rapidly over a small spatial distance: these are referred to as 'concave corners'. These concave corners need to be propagated differently from the material points on the foam front itself. Typically the corner must move faster than those material points, otherwise spurious numerical artifacts develop in the comp uted shape of the front. A propagation rule or ‘speed up’ rule is derived for the concave corners, which is shown to be sensitive to the level of anisotropy in the permeability of the reservoir and also sensitive to the orientation of the corners themselves. In particular if a corner in an anisotropic reservoir were to be propagated according to an isotropic speed up rule, this might not be sufficient to suppress spurious numerical artifacts, at least for certain orientations of the corner. On the other hand, systems that are both heterogeneous and anisotropic tend to be well behaved numerically, regard less of whether one uses the isotropic or anisotropic speed up rule for corners. This comes about be cause, in the heterogeneous and anisotropic case, the orientation of the corner is such that the 'correct' anisotropic speed is just very slightly less than the ‘incorrect’ isotropic one. The anisotropic rule does however manage to keep the corner very slightly sharper than the isotropic rule does

Viscous froth model applied to multiple topological transformations of bubbles flowing in a channel : three-bubble case

A two-dimensional foam system comprised of three bubbles is studied via dynamic simulations with the viscous froth model. The bubbles are arranged in a staircase configuration and move along a channel due to an imposed driving back pressure. Depending on the bubble size relative to channel size, the three-bubble system can undergo topological transformations (as for a simpler staircase structure, known as the simple lens) or it can reach a geometrically invariant migrating state (as for an infinite staircase structure). A methodology used previously determined the system evolution up to the first topological transformation, but evolution beyond this was not studied before. To address this, unsteady state three-bubble simulations are realised here, extending beyond the first transformation. For sufficiently high imposed back pressures, a sequence of topological transformations occurs before a steadily migrating shape is reached, typically in a topology such that an equal number of films connect to both channel walls

Viscous froth model applied to the dynamic simulation of bubbles flowing in a channel : three-bubble case

A two-dimensional foam system comprised of three bubbles is studied via simulations with the viscous froth model. Bubbles are arranged in a so called staircase configuration and move along a channel due to imposed driving back pressure. This flowing three-bubble system has been studied previously on the basis that it interpolates between a simpler staircase structure (a simple lens, which breaks up via so called topological transformations if driven at high pressure) and an infinite staircase (which sustains arbitrarily large driving pressure without breaking). Depending on bubble size relative to channel size, different solution branches for the three-bubble system were found: certain branches terminate (as for the simple lens) in topological transformations and others reach (as for an infinite staircase) a geometrically invariant migrating state. The methodology used previously was however a purely steady state one, and hence did not interrogate stability of the various branches, nor the role of imposing different driving pressures upon topological transformation type. To address this, unsteady state three-bubble simulations are realized here. Stable solution branches without topological transformation exist for comparatively low driving pressures. For sufficiently high imposed back pressures however, topological transformations occur, albeit with imposed pressure now influencing the transformation type

The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation

Objective—The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial wall’s response to injury. The identification and characterization of the NF-kB essential modulator– binding domain (NBD) peptide, which can block the activation of the IkB kinase complex, have provided an opportunity to selectively abrogate the inflammation-induced activation of NF-kB. The aim of the present study was to evaluate the effect of the NBD peptide on neointimal formation.<br></br> Methods and Results—In the rat carotid artery balloon angioplasty model, local treatment with the NBD peptide (300 microg/site) significantly reduced the number of proliferating cells at day 7 (by 40%; P<0.01) and reduced injury-induced neointimal formation (by 50%; P<0.001) at day 14. These effects were associated with a significant reduction of NF-kB activation and monocyte chemotactic protein-1 expression in the carotid arteries of rats treated with the peptide. In addition, the NBD peptide (0.01 to 1 micromol/L) reduced rat smooth muscle cell proliferation, migration, and invasion in vitro. Similar results were observed in apolipoprotein E-/-, mice in which the NBD peptide (150 microg/site) reduced wire-induced neointimal formation at day 28 (by 47%; P<0.01).<br></br> Conclusion—The NBD peptide reduces neointimal formation and smooth muscle cell proliferation/migration, both effects associated with the inhibition of NF-kB activation

Frontal brain asymmetries as effective parameters to assess the quality of audiovisual stimuli perception in adult and young cochlear implant users

How is music perceived by cochlear implant (CI) users? This question arises as "the next step" given the impressive performance obtained by these patients in language perception. Furthermore, how can music perception be evaluated beyond self-report rating, in order to obtain measurable data? To address this question, estimation of the frontal electroencephalographic (EEG) alpha activity imbalance, acquired through a 19-channel EEG cap, appears to be a suitable instrument to measure the approach/withdrawal (AW index) reaction to external stimuli. Specifically, a greater value of AW indicates an increased propensity to stimulus approach, and vice versa a lower one a tendency to withdraw from the stimulus. Additionally, due to prelingually and postlingually deafened pathology acquisition, children and adults, respectively, would probably differ in music perception. The aim of the present study was to investigate children and adult CI users, in unilateral (UCI) and bilateral (BCI) implantation conditions, during three experimental situations of music exposure (normal, distorted and mute). Additionally, a study of functional connectivity patterns within cerebral networks was performed to investigate functioning patterns in different experimental populations. As a general result, congruency among patterns between BCI patients and control (CTRL) subjects was seen, characterised by lowest values for the distorted condition (vs. normal and mute conditions) in the AW index and in the connectivity analysis. Additionally, the normal and distorted conditions were significantly different in CI and CTRL adults, and in CTRL children, but not in CI children. These results suggest a higher capacity of discrimination and approach motivation towards normal music in CTRL and BCI subjects, but not for UCI patients. Therefore, for perception of music CTRL and BCI participants appear more similar than UCI subjects, as estimated by measurable and not self-reported parameters

DNA uptake into nuclei: Numerical and analytical results

The dynamics of polymer translocation through a pore has been the subject of recent theoretical and experimental works. We have considered theoretical estimates and performed computer simulations to understand the mechanism of DNA uptake into the cell nucleus, a phenomenon experimentally investigated by attaching a small bead to the free end of the double helix and pulling this bead with the help of an optical trap. The experiments show that the uptake is monotonous and slows down when the remaining DNA segment becomes very short. Numerical and analytical studies of the entropic repulsion between the DNA filament and the membrane wall suggest a new interpretation of the experimental observations. Our results indicate that the repulsion monotonically decreases as the uptake progresses. Thus, the DNA is pulled in (i) either by a small force of unknown origin, and then the slowing down can be interpreted only statistically; (ii) or by a strong but slow ratchet mechanism, which would naturally explain the observed monotonicity, but then the slowing down requires additional explanations. Only further experiments can unambiguously distinguish between these two mechanisms.Comment: 12 pages, 6 figures, submitted to J. Phys. Cond. Ma