Digital micromirror devices for laser-based manufacturing

Digital Micromirror Devices (DMDs), containing arrays of around one million individually-controllable ~10µm square mirrors, provide an extremely cost-effective and practical method to modulate the spatial beam profile of a pulsed laser source for both additive and subtractive laser processing and printing. When demagnified by a factor of ~100 in one dimension (hence ~10,000 in area) a ~1mJ/cm2 laser pulse reflected from the mirrors on the DMD surface that are switched to the 'on' position, attains a fluence of ~10J/cm2 at the workpiece, which is more than sufficient to ablate most materials of interest to the laser-manufacturing community. More familiar in the context of high values of magnification by the laser projection industry, reversing the role to use them for equally high values of demagnification opens up a wealth of possibilities for ablation, multiphoton polymerization, security marking and fabrication of features that perhaps surprisingly can be well below the wavelength of the laser used. Of key relevance is that very high-resolution patterning can be achieved by a single laser pulse, and step-and-repeat processes, when combined with the refresh rates of the DMD pattern that are currently at the 30kHz level, open up the possibility of processing areas of up to 1cm2 per second with micron-scale resolution where each ~100µm x 100µm area patterned per pulse can display arbitrary pixelated content. We will discuss the application of DMD-baser laser processing to the following areas of interest to the laser-manufacturing community

Femtosecond laser-induced patterned transfer of intact semiconductor and polymer thin films via a digital micromirror device

The laser-induced forward transfer (LIFT) of thin films is an attractive technique to deposit materials on a size scale that can span nanometres to millimeters. During LIFT, the energy of a laser pulse is absorbed in a small volume of a thin film (donor) causing an explosive expansion which is used to propel a portion of the donor away from the carrier substrate and transfer it onto a receiver substrate as shown in Fig.1(a). Ultrashort laser systems can limit laser damage to remaining areas of the donor usually present using laser systems with longer (nanosecond) pulse widths

Yb:YAG planar waveguide lasers grown by pulsed laser deposition: 70% slope efficiencies at 16 W of output power

We present our recent advances in the use of pulsed laser deposition (PLD) to fabricate active gain elements for use as amplifiers and laser oscillators. Record output powers exceeding 16 W and slope efficiencies of 70% are reported for optimized epitaxial growth of Yb(7.5%):YAG on to YAG substrates. We show for the first time that the performance of PLD material can meet or even exceed that of materials grown by more established methods such as the Czochralski technique. Details of fabrication, characterization and laser performance are presented in addition to outlining expected future improvements

Comparative study of rare-earth doped sesquioxides grown by pulsed laser deposition and their performance as planar waveguide lasers

The sesquioxides yttria, scandia and lutetia have been identified as promising host materials for high power lasers due to their excellent thermal properties, their ability to incorporate RE-ions and their resulting spectroscopic properties [1]. However, the melting points of these materials exceed 2400°C and are therefore problematic to grow from the melt. Pulsed laser deposition (PLD) is an alternative method of growing thin crystalline films of these materials, avoiding the requirement for such high temperature growth

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Pulsed laser deposition of thin films for optical and lasing waveguides (including tricks, tips and techniques to maximize the chances of growing what you actually want)

In the last 20-25 years, the technique of pulsed laser deposition (PLD) has emerged as a versatile, relatively fast and conceptually simple technique for growing a range of thin films of essentially any material. And while it is true that you will almost always grow something for your efforts, trying to optimise PLD so that what you grow is what you intended to grow is a different matter entirely. In this talk, I will use the growth of thin film doped crystalline materials that we are using as lasing waveguide structures as an example of how to tame the PLD process to produce high quality films that can match bulk crystal samples in terms of their final lasing performance. I will cover the technical aspects of substrate heating, particulate removal strategies, layer uniformity and crystal quality, and then move onto more advanced concepts such as single target versus multitarget geometries, mixed, layered, superlattice and Bragg structures and finally growth of ‘polo’ crystals, that have selected dopants only in the centre of the film, for application as thin disc lasers

1.2 W Yb:Y₂O₃ planar waveguide laser

A 12µm thick composite Yb-doped and undoped yttria layer is grown on a YAG substrate by pulsed laser deposition. For 8.5W of incident laser diode pump power the waveguide laser emits 1.2W at 1030nm

Investigation of the rapid fabrication of multiple nanofoam materials via femtosecond laser irradiation

Nanofoams are permeable, nanostructured materials, which have applications in many areas, including electronics, biological sciences and aerospace engineering [1-4]. Nanofoam fabrication using an ultrafast laser enables control over the precise location as well as the fabrication rate, leading to the possibility of applications such as evanescent sensors and energy harvesting devices. Here, we extend our initial work on glass nanofoam fabrication [5] by demonstrating the production of metal, ceramic, polymer and novel chalcogenide glass nanofoam at atmospheric pressure, with dimensions of ~hundred microns in height and millimetre-square in area. Our investigation showed that both the volume and density of the nanofoam was a function of both the material as well as the exposure protocol (number of pulses and their energy density)

Digital multimirror devices for precision laser micromachining

• DMD devices for laser processing• Laser:- Ablation- Multiphoton polymerisation (MPP)- Laser-induced forward transfer (LIFT)- all within the context of microscale materials processing• Summar